中国三城市麻疹母婴配对及小月龄母传抗体水平消长研究
중국삼성시마진모영배대급소월령모전항체수평소장연구
Levels of transition on maternal transferred measles antibody in infants in 3 cities in China
  • 万方数据
    中华流行病学杂志 중화류행병학잡지
    CHINESE JOURNAL OF EPIDEMIOLOGY
    2008年 11期 1074-1077 ,共4页

    许国章%马瑞%徐宏杰%马衍辉%董红军%李岩%胡风霞%倪红霞%边国林%梁英%刘岚铮%周绍英%怀清杰%韩秀云

    허국장%마서%서굉걸%마연휘%동홍군%리암%호풍하%예홍하%변국림%량영%류람쟁%주소영%부청걸%한수운

    麻疹%婴儿%流行特征%母传抗体 痳疹%嬰兒%流行特徵%母傳抗體
    마진%영인%류행특정%모전항체
    Measles%Infant%Epidemiological characteristics%Maternal-transferred antibody
    目的 了解宁波市、哈尔滨市和济南市小月龄婴儿麻疹年龄构成变化及母传抗体衰减情况.方法 收集2004-2007年麻疹疫情资料并分析;同时采用血清流行病学方法进行麻疹母传抗体研究.结果 三城市麻疹病例主要发生在<1岁婴儿中,且<1岁组麻疹年龄发病率最高;三城市婴儿麻疹病例构成中均以5～8月龄为主.婴儿出生时麻疹抗体阳性率为89.3%,几何平均滴度倒数(GMRT)为738.93;6月龄和8月龄抗体阳性率分别只有6.9%和6.7%,GMRT分别为6.89和3.69;0～8月龄婴儿麻疹抗体阳性率随着月龄的增长呈趋势性下降;母亲的抗体阳性率为84.3%,GMRT为516.94,母亲麻疹抗体主要以低、中水平为主,分别占50.4%和30.3%;母婴麻疹抗体相关系数为0.840.结论 麻疹母传抗体下降,6月龄和8月龄婴儿抗体阳性率较低,几乎无保护作用.
    목적 료해저파시、합이빈시화제남시소월령영인마진년령구성변화급모전항체쇠감정황.방법 수집2004-2007년마진역정자료병분석;동시채용혈청류행병학방법진행마진모전항체연구.결과 삼성시마진병례주요발생재<1세영인중,차<1세조마진년령발병솔최고;삼성시영인마진병례구성중균이5～8월령위주.영인출생시마진항체양성솔위89.3%,궤하평균적도도수(GMRT)위738.93;6월령화8월령항체양성솔분별지유6.9%화6.7%,GMRT분별위6.89화3.69;0～8월령영인마진항체양성솔수착월령적증장정추세성하강;모친적항체양성솔위84.3%,GMRT위516.94,모친마진항체주요이저、중수평위주,분별점50.4%화30.3%;모영마진항체상관계수위0.840.결론 마진모전항체하강,6월령화8월령영인항체양성솔교저,궤호무보호작용.
    Objective To understand the epidemiological characteristics of age distribution of measles and related policies on measles vaccines (live; MV) in infants through analyzing the antibody levels of comparison in maternal-infant pairs. Transition of immunity in infants was also studied to provide theoretic basis for measles immunization strategy and to reduce the incidence of month-old infants. Methods In cities of Ningbo, Harbin, and Jinan from Zhejiang, Heilongiiang and Shandong provinces, data was collected from 2004 to 2007 and analyzed regarding the epidemic situation of measles. Studies on maternal-transferred measles antibody were carried our sero-epidemiologically. Results Most of the measles cases were found among babies younger than 12 months,and the incidence of < 1 year olds had been increasing.The distribution was dominated by 5-8 month olds in infant measles cases. The positive rate and GRMT of measles antibody in newborns were 89.3 percent and 738.93. The positive rate of the measles antibody and GMRT of the 6-month infant were 6.9 % and 6.89, while 6.7 % and 3.69 in 8-month infant. There wasa declining trend of the positive rate of the measles antibody during the newborns to 8-month infant. The positive rate and GRMT of measles antibody in mothers were 84.3 percent and 516.94. Mother's measles antibodies mainly to be at low and moderate level, which accounted for 50.4 percent and 30.3 percent respectively, the correlation coefficient between mother and infant was 0. 840. Conclusion Maternal-transferred measles antibody decreased as the growth of infants. The positive rates of measles antibody were quite low in 6-month and 8-month olds which were the age range that needs most attention.
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