肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2011年
2期
137-139
,共3页
微管蛋白%紫杉醇%抗药性,肿瘤
微管蛋白%紫杉醇%抗藥性,腫瘤
미관단백%자삼순%항약성,종류
Tubulin%Taxol%Drug resistance,neoplasms
紫杉醇依赖于促进微管聚合,抑制微管解聚,诱导肿瘤细胞凋亡,但肿瘤细胞对紫杉醇的耐药性是限制其临床应用的重要因素.一些基础、临床研究均证实β微管蛋白Ⅲ高表达与紫杉醇耐药、预后不良密切相关.
紫杉醇依賴于促進微管聚閤,抑製微管解聚,誘導腫瘤細胞凋亡,但腫瘤細胞對紫杉醇的耐藥性是限製其臨床應用的重要因素.一些基礎、臨床研究均證實β微管蛋白Ⅲ高錶達與紫杉醇耐藥、預後不良密切相關.
자삼순의뢰우촉진미관취합,억제미관해취,유도종류세포조망,단종류세포대자삼순적내약성시한제기림상응용적중요인소.일사기출、림상연구균증실β미관단백Ⅲ고표체여자삼순내약、예후불량밀절상관.
The taxol s effect of inducing apoptosis is mainly related to its ability to promote tubulin polymerization and prevent tubulin chain depolarization. Drug resistance is the main restriction factor for clinical usage of taxol. Some basic and clinical studies support that poor response to taxol and poor prognosis are related to overexpression of β tubulin Ⅲ.
