CAJ | 학술논문

目的评估注射皮肤填充剂爱贝芙(Artecoll)后,再联合使用激光等其他美容手段后的有效性及安全性.方法体外实验:直接对爱贝芙进行点阵激光照射后,观察其微球结构的完整性与表面的光滑程度等变化.动物实验:分别用猪及豚鼠建立相应的短期和中长期填充剂动物模型,并进行后续的激光、射频等治疗,光镜、电镜观察比较激光治疗前后的微球结构及组织的炎症程度变化等.结果体外研究结果,未发现经多次激光照射后爱贝芙中的聚甲基丙烯酸甲酯(polymethylmethacrylate,PMMA)微球的形状和结构发生变形或破坏等情况,微球表面仍光滑如初.动物实验表明,爱贝芙较长期置入动物后,PMMA微球仍能保持良好的结构和光滑的表面,未见微球被吞噬破坏.在多次激光等其他手段治疗后,微球置入部位炎症细胞浸润程度与未经激光治疗的对照组比较无差异.结论爱贝芙是一种安全有效的永久性皮肤填充剂,临床使用某些激光、射频的治疗不会影响其安全性.
목적 평고주사피부전충제애패부(Artecoll)후,재연합사용격광등기타미용수단후적유효성급안전성.방법 체외실험:직접대애패부진행점진격광조사후,관찰기미구결구적완정성여표면적광활정도등변화.동물실험:분별용저급돈서건립상응적단기화중장기전충제동물모형,병진행후속적격광、사빈등치료,광경、전경관찰비교격광치료전후적미구결구급조직적염증정도변화등.결과 체외연구결과,미발현경다차격광조사후애패부중적취갑기병희산갑지(polymethylmethacrylate,PMMA)미구적형상화결구발생변형혹파배등정황,미구표면잉광활여초.동물실험표명,애패부교장기치입동물후,PMMA미구잉능보지량호적결구화광활적표면,미견미구피탄서파배.재다차격광등기타수단치료후,미구치입부위염증세포침윤정도여미경격광치료적대조조비교무차이.결론 애패부시일충안전유효적영구성피부전충제,림상사용모사격광、사빈적치료불회영향기안전성.
Objective To evaluate the safety and efficacy of polymethylmethacrylate/PMMA (Artecoll) as an injectable dermal filler after using laser, radiofrequency and intensive pulse light. Methods In vitro, factional photothermolysis (Affirm) was directly used on the PMMA to see if there was any change in the structure or surface smoothness. In vivo, pig and guinea pig were used as the short-term and long-term models, respectively, for Artecoll. The dermal filler was first injected and then laser treatments conducted.The skin sample was observed through light microscope, scanning electronic microscope and transmission electronic microscope to see whether there were any structural changes, infiltration of inflammatory cells and the regeneration of collagen. Results Through the microscopic observation of in vitro experiment and the animal models, no distortion or rupture of the microsphere were found after the laser treatment. No uneven surface was found in the PMMA microsphere either. The microshpere was surrounded by the inflammatory cells. The infiltration was mild to intermediate with few foreign body giant cells even after several treatments of laser. There was no macrophage seen. But the collagen regeneration was distinguishable after the laser treatment. No obvious structural change was found eventually. Conclusion Artecoll is a safe and effective permanent injectable dermal filler for wrinkle reduction and contour refining.