中华眼底病杂志
中華眼底病雜誌
중화안저병잡지
CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
2009年
6期
421-424
,共4页
张姗姗%杨安怀%陈长征%易莲芳%邢怡桥
張姍姍%楊安懷%陳長徵%易蓮芳%邢怡橋
장산산%양안부%진장정%역련방%형이교
视网膜电描记术/利用%视网膜静脉闭塞/诊断
視網膜電描記術/利用%視網膜靜脈閉塞/診斷
시망막전묘기술/이용%시망막정맥폐새/진단
Electroretinography/utilization%Retinal vein occlusion/diagnosis
目的 观察视网膜静脉阻塞(RVO)患者视网膜电图(ERG)明视负向反应(PhNR)的变化特点.方法 对间接检眼镜、荧光素眼底血管造影(FFA)检查确诊的RVO患者30例30只患眼以及对侧健康眼进行视力、视野、闪光ERG(FERG)检查,同时选取与其性别、年龄相匹配的正常人25例50只眼作为正常组进行FERG检查.所有检查均按常规方法进行.RVO患者中,视网膜中央静脉阻塞(CRVO)患者14例14只眼、视网膜分支静脉阻塞(BRVO)患者16例16只眼.根据其病史及FFA检查结果,将其按病程时间划分为小于1个月、1～3个月、大于3个月组;另外再根据RVO分型标准及具体检查结果,将RVO患者分为缺血型和非缺血型.对比分析RVO患眼与对侧健康眼以及正常眼PhNR振幅变化及ERG其他参数指标,包括振荡电位(Ops),视锥细胞反应(Cone-a、Cone-b),视杆细胞反应(Rod-b),暗适应眼的最大反应(Max-a、Max-b),30 Hz闪烁光反应(30 Hz)的差异以及PhNR振幅变化与RVO疾病缺血类型、病程的关系.结果 PhNR振幅在CRVO患眼为(28.20±5.80)μV,BRVO患眼为(36.96±4.71)μV,对侧健眼为(61.25±3.93)μV,正常眼为(59.33±16.92)μV.CRVO组与对侧健眼、正常组比较,差异有统计学意义(F=10.69,9.80;P＜0.001),BRVO组与对侧健眼、正常组比较,差异有统计学意义(F=9.69,9.75;P＜0.001).CRVO组中缺血型PhNR值为(22.77±5.73)μV,非缺血型为(36.63±12.91)μV,二者差异有统计学意义(t=6.54,P＜0.01);BRVO组缺血型PhNR值为(32.39±13.22)μV,非缺血型为(46.73±10.43)μV,二者差异无统计学意义(t=2.12,P＜0.05);病程小于1个月组CRVO与BRVO分别为(24.58±4.60)、(27.94±15.73)μV,1～3个月组分别为(50.39±13.80)、(58.69±12.43)μV,大于3个月组为(25.40±19.94)、(34.48±16.72)μV,CRVO中1～3个月组与大于3个月组差异有统计学意义(F=4.30,P＜0.01).结论 RVO患眼的PhNR振幅较对侧健康眼以及正常对照眼明显降低,缺血型较非缺血型降低,随病程变化呈现下降、上升、下降的变化趋势.
目的 觀察視網膜靜脈阻塞(RVO)患者視網膜電圖(ERG)明視負嚮反應(PhNR)的變化特點.方法 對間接檢眼鏡、熒光素眼底血管造影(FFA)檢查確診的RVO患者30例30隻患眼以及對側健康眼進行視力、視野、閃光ERG(FERG)檢查,同時選取與其性彆、年齡相匹配的正常人25例50隻眼作為正常組進行FERG檢查.所有檢查均按常規方法進行.RVO患者中,視網膜中央靜脈阻塞(CRVO)患者14例14隻眼、視網膜分支靜脈阻塞(BRVO)患者16例16隻眼.根據其病史及FFA檢查結果,將其按病程時間劃分為小于1箇月、1～3箇月、大于3箇月組;另外再根據RVO分型標準及具體檢查結果,將RVO患者分為缺血型和非缺血型.對比分析RVO患眼與對側健康眼以及正常眼PhNR振幅變化及ERG其他參數指標,包括振盪電位(Ops),視錐細胞反應(Cone-a、Cone-b),視桿細胞反應(Rod-b),暗適應眼的最大反應(Max-a、Max-b),30 Hz閃爍光反應(30 Hz)的差異以及PhNR振幅變化與RVO疾病缺血類型、病程的關繫.結果 PhNR振幅在CRVO患眼為(28.20±5.80)μV,BRVO患眼為(36.96±4.71)μV,對側健眼為(61.25±3.93)μV,正常眼為(59.33±16.92)μV.CRVO組與對側健眼、正常組比較,差異有統計學意義(F=10.69,9.80;P＜0.001),BRVO組與對側健眼、正常組比較,差異有統計學意義(F=9.69,9.75;P＜0.001).CRVO組中缺血型PhNR值為(22.77±5.73)μV,非缺血型為(36.63±12.91)μV,二者差異有統計學意義(t=6.54,P＜0.01);BRVO組缺血型PhNR值為(32.39±13.22)μV,非缺血型為(46.73±10.43)μV,二者差異無統計學意義(t=2.12,P＜0.05);病程小于1箇月組CRVO與BRVO分彆為(24.58±4.60)、(27.94±15.73)μV,1～3箇月組分彆為(50.39±13.80)、(58.69±12.43)μV,大于3箇月組為(25.40±19.94)、(34.48±16.72)μV,CRVO中1～3箇月組與大于3箇月組差異有統計學意義(F=4.30,P＜0.01).結論 RVO患眼的PhNR振幅較對側健康眼以及正常對照眼明顯降低,缺血型較非缺血型降低,隨病程變化呈現下降、上升、下降的變化趨勢.
목적 관찰시망막정맥조새(RVO)환자시망막전도(ERG)명시부향반응(PhNR)적변화특점.방법 대간접검안경、형광소안저혈관조영(FFA)검사학진적RVO환자30례30지환안이급대측건강안진행시력、시야、섬광ERG(FERG)검사,동시선취여기성별、년령상필배적정상인25례50지안작위정상조진행FERG검사.소유검사균안상규방법진행.RVO환자중,시망막중앙정맥조새(CRVO)환자14례14지안、시망막분지정맥조새(BRVO)환자16례16지안.근거기병사급FFA검사결과,장기안병정시간화분위소우1개월、1～3개월、대우3개월조;령외재근거RVO분형표준급구체검사결과,장RVO환자분위결혈형화비결혈형.대비분석RVO환안여대측건강안이급정상안PhNR진폭변화급ERG기타삼수지표,포괄진탕전위(Ops),시추세포반응(Cone-a、Cone-b),시간세포반응(Rod-b),암괄응안적최대반응(Max-a、Max-b),30 Hz섬삭광반응(30 Hz)적차이이급PhNR진폭변화여RVO질병결혈류형、병정적관계.결과 PhNR진폭재CRVO환안위(28.20±5.80)μV,BRVO환안위(36.96±4.71)μV,대측건안위(61.25±3.93)μV,정상안위(59.33±16.92)μV.CRVO조여대측건안、정상조비교,차이유통계학의의(F=10.69,9.80;P＜0.001),BRVO조여대측건안、정상조비교,차이유통계학의의(F=9.69,9.75;P＜0.001).CRVO조중결혈형PhNR치위(22.77±5.73)μV,비결혈형위(36.63±12.91)μV,이자차이유통계학의의(t=6.54,P＜0.01);BRVO조결혈형PhNR치위(32.39±13.22)μV,비결혈형위(46.73±10.43)μV,이자차이무통계학의의(t=2.12,P＜0.05);병정소우1개월조CRVO여BRVO분별위(24.58±4.60)、(27.94±15.73)μV,1～3개월조분별위(50.39±13.80)、(58.69±12.43)μV,대우3개월조위(25.40±19.94)、(34.48±16.72)μV,CRVO중1～3개월조여대우3개월조차이유통계학의의(F=4.30,P＜0.01).결론 RVO환안적PhNR진폭교대측건강안이급정상대조안명현강저,결혈형교비결혈형강저,수병정변화정현하강、상승、하강적변화추세.
Objective To observe the changes of photopic negative response (PhNR) of electroretinography (ERG) in patients with retinal vein occlusion (RVO).Methods A total of 30 patients (30 eyes) with retinal vein occlusion (RVO) diagnosed by indirect ophthalmoscopy and fundus fluorescein angiography (FFA) were selected;the unaffected fellow eyes of the patients and another 25 healthy agematched individuals (50 eyes) were cllected as the normal control.All of the patients underwent the examination of visual acuity,visual field,and flash-ERG (FERG);the normal control ones underwent FERG.In the 30 patients with RVO,there were 14 with central RVO (CRVO) and 16 with branch RVO (BRVO).According to the disease history and results of FFA,the patients were divided into 3 time groups:＜1 month,1-3 months,and＞3 months;according to the types of RVO,the patients were divided into ischemic and non-ischemic group.The amplitude of PhNR and other parameters were analysed.The relationship among the amplitude of PhNR and RVO types and time course were analyzed.Results The amplitude of PhNR in the CRVO and BRVO eyes was (28.20±5.8) and (36.96±4.71) μV,respectively;those in the unaffected fellow and control eyes was (61.25±3.93) and (59.33±16.92) μV,respectively;the amplitude of PhNR was significantly smaller in the CRVO and BRVO eyes than those in the unaffected fellow or control eyes (F=10.69 and 9.80,P＜0.001;F=9.69 and 9.75,P＜0.001).The amplitude of PhNR in ischemic and non-ischemic group in CRVO eyes was (22.77±15.73) and (36.63±12.91)μV,respectively;the difference between the two groups was significant(t=6.54,P＜0.01).The amplitude of PhNR in ischemic and non-ischemic group in BRVO eyes was (32.39±13.22) and (46.73±10.43)μV,respectively;there was no significant difference between the two groups (t=2.12,P＜0.05).The amplitude of PhNR was (24.58±14.60) and (27.94±15.73)μV,respectively,in CRVO and BRVO eyes with＜1 month disease course;was (50.39±13.80) and (58.69±12.43)μV in those with 1-3 months disease course;and was (25.40±19.94) and (34.48±16.72)μV in those with＞3 months diseases course.Significant difference was found between the 1-3 months group and＞3 months group in CRVO eyes (F=4.30,P＜0.01).Conclusions The amplitude of PhNRs was significantly smaller in RVO eyes than those in the unaffected fellow or control eyes .The amplitude of PhNR amplitude of ischemic type was smaller than that of non-ischemic type.The amplitude of PhNR has descending,ascending,and descending tendency during the disease courses.
