临床儿科杂志
臨床兒科雜誌
림상인과잡지
2010年
1期
73-75
,共3页
吴红芳%符宝敏%陈肖鸣%王宗敏
吳紅芳%符寶敏%陳肖鳴%王宗敏
오홍방%부보민%진초명%왕종민
CyclinD1蛋白%p53蛋白%肾母细胞瘤%免疫组化
CyclinD1蛋白%p53蛋白%腎母細胞瘤%免疫組化
CyclinD1단백%p53단백%신모세포류%면역조화
CyclinD1%p53%nephroblastoma%immunohistochemistry
目的 探讨CyclinD1蛋白在肾母细胞瘤中表达及其意义.方法 将28例肾母细胞瘤和19例瘤旁肾组织制作组织芯片,并用免疫组织化学方法 检测其中CyclinD1蛋白及p53蛋白的表达.结果 CyclinD1和p53蛋白在肾母细胞瘤和瘤旁肾组织标本中的阳性表达率差异有统计学意义(P<0.05),在肾母细胞瘤不同分化程度组差异亦有统计学意义(P<0.05).CyclinD1蛋白表达与p53蛋白表达呈正相关(P<0.05).结论 CyelinD1及p53可作为判断肾母细胞瘤分化程度的标志物,CyclinD1蛋白异常表达及p53突变可能在肾母细胞瘤发生中发挥重要作用.
目的 探討CyclinD1蛋白在腎母細胞瘤中錶達及其意義.方法 將28例腎母細胞瘤和19例瘤徬腎組織製作組織芯片,併用免疫組織化學方法 檢測其中CyclinD1蛋白及p53蛋白的錶達.結果 CyclinD1和p53蛋白在腎母細胞瘤和瘤徬腎組織標本中的暘性錶達率差異有統計學意義(P<0.05),在腎母細胞瘤不同分化程度組差異亦有統計學意義(P<0.05).CyclinD1蛋白錶達與p53蛋白錶達呈正相關(P<0.05).結論 CyelinD1及p53可作為判斷腎母細胞瘤分化程度的標誌物,CyclinD1蛋白異常錶達及p53突變可能在腎母細胞瘤髮生中髮揮重要作用.
목적 탐토CyclinD1단백재신모세포류중표체급기의의.방법 장28례신모세포류화19례류방신조직제작조직심편,병용면역조직화학방법 검측기중CyclinD1단백급p53단백적표체.결과 CyclinD1화p53단백재신모세포류화류방신조직표본중적양성표체솔차이유통계학의의(P<0.05),재신모세포류불동분화정도조차이역유통계학의의(P<0.05).CyclinD1단백표체여p53단백표체정정상관(P<0.05).결론 CyelinD1급p53가작위판단신모세포류분화정도적표지물,CyclinD1단백이상표체급p53돌변가능재신모세포류발생중발휘중요작용.
Objective To investigate the expression of CyelinD1 protein in nephroblastoma.Methods The tissue microarray were made in 28 cases of nephroblastoma and 19 cases of renal tissue adjacent to tumor.The expression of CyclinD1 and p53 proteins were detected by immunohistochemistry.Results The positive rate of the expression of CyclinD1 and p53 protein was significantly different between nephroblastoma and renal tissue adjacent to tumor (P < 0.05).The positive rate of the expression of CyclinD1 and p53 protein was significantly different in different degree of differentiation of nephroblastoma (P < 0.05).The expression of CyclinD1 and p53 protein was positively correlated (P < 0.05).Conclusions The CyclinD1 and p53 might be used as the marks for estimating the degree of differentiation of nephroblastoma.The over-expression of CyclinD1 and the mutation of p53 might play the vital role in nephroblastoma.
