CAJ | 학술논문

目的研究鱼皮胶原肽对小鼠皮肤胶原代谢的影响.方法利用盐酸水解鼠皮使得羟脯氨酸(HYP)游离出来,用可见分光光度计法测定小鼠皮肤中HYP的含量,再折算成胶原蛋白含量,并将22只小白鼠分为鱼皮胶原肽组和对照组,分别对小鼠皮肤的胶原蛋白含量进行比较.结果经t检验,人体推荐量的20倍剂量鱼皮胶原肽组的胶原蛋白含量与对照组相比有统计学意义[鱼皮胶原肽组(69.79%±4.36%);对照组(64.36%±4.36%),P＜0.05],且对实验组小鼠体重与对照组相比显著减少[鱼皮胶原肽组(32.10±3.16)g;对照组(36.50±2.19)g,P＜0.05].结论鱼皮胶原肽具有增加皮肤胶原蛋白含量的作用,同时似乎还有减肥的功能,作为一种新兴的化妆品原料,鱼皮胶原肽将拥有广阔的发展前景.
목적 연구어피효원태대소서피부효원대사적영향.방법 이용염산수해서피사득간포안산(HYP)유리출래,용가견분광광도계법측정소서피부중HYP적함량,재절산성효원단백함량,병장22지소백서분위어피효원태조화대조조,분별대소서피부적효원단백함량진행비교.결과 경t검험,인체추천량적20배제량어피효원태조적효원단백함량여대조조상비유통계학의의[어피효원태조(69.79%±4.36%);대조조(64.36%±4.36%),P＜0.05],차대실험조소서체중여대조조상비현저감소[어피효원태조(32.10±3.16)g;대조조(36.50±2.19)g,P＜0.05].결론 어피효원태구유증가피부효원단백함량적작용,동시사호환유감비적공능,작위일충신흥적화장품원료,어피효원태장옹유엄활적발전전경.
Objective To study the effect of fish skin collagen peptide on skin collagen metabolism.Methods Twenty-two rots were divided into treatment and control groups.In rats of the treatment group,fish skin collagen peptide at a dose that is 20 times of the recommended dose for human was added to the food for 40 days. Skin HYP was isolated by hydrolysis with hydrochloric acid. The concentration of skin HYP was determined by visible spectrophotometer and converted it to collagen concentration and compared between the 2 groups.Results The skin collagen concentration was significantly higher in the treatment group than that in the control group (69.79%±4.36%;64.36%±4.36%,P＜0.05).At 40 days,the average body weight of rats in the treatment group was (32.1±3.16)g;while it was(36.5± 2.19)g in the control group (P＜0.05).Conclusion Fish skin collagen peptide may help to increase collagen concentration of skin and control body weight.