CAJ | 학술논문

目的了解北京市5岁及以上常住人口接种新型甲型H1N1流感(简称甲型流感)病毒疫苗前的人群抗体水平,为确定防控重点人群提供依据. 方法 2009年10至12月选择未接种疫苗、未明确诊断为甲型流感的北京市常住人口,按照年龄组进行分层,用血凝抑制试验检测新型甲型H1N1流感病毒抗体(简称抗体),使用抗体几何平均滴度进行不同人群的比较. 结果共监测3499名调查对象,平均抗体水平为1:8.03,阳性率为11.06%(387/3499);5～19岁人群抗体水平和阳性率较高,其抗体水平均>1:8.9,抗体阳性率均>12%. 结论不同人群抗体水平受该人群疫情流行强度的影响,学生人群抗体水平和阳性率高与学校疫情流行强度高有关;北京市采取的重点人群和全人群的免疫策略正确,但目前人群免疫力尚未达到理想状态,甲型流感仍有可能在北京市流行.
목적 료해북경시5세급이상상주인구접충신형갑형H1N1류감(간칭갑형류감)병독역묘전적인군항체수평,위학정방공중점인군제공의거. 방법 2009년10지12월선택미접충역묘、미명학진단위갑형류감적북경시상주인구,안조년령조진행분층,용혈응억제시험검측신형갑형H1N1류감병독항체(간칭항체),사용항체궤하평균적도진행불동인군적비교. 결과 공감측3499명조사대상,평균항체수평위1:8.03,양성솔위11.06%(387/3499);5～19세인군항체수평화양성솔교고,기항체수평균>1:8.9,항체양성솔균>12%. 결론 불동인군항체수평수해인군역정류행강도적영향,학생인군항체수평화양성솔고여학교역정류행강도고유관;북경시채취적중점인군화전인군적면역책략정학,단목전인군면역력상미체도이상상태,갑형류감잉유가능재북경시류행.
Objective To explore the herd immunity against influenza A(H1N1)in pre-vaccinated residents aged over 5 years.and therefore to provide data for vaccination policies in high risk populations. Methods From October to December 2009,Beijing CDC conducted a serum survey of the hovel influenza A (H1N1) in the local residents,stratified in 10 age groups between 5 years to over 60 years,without H1N1 vaccination history and disease history.Hemagglutination inhibition (HI) assays were performed at Beijing CDC.Statistical significance was determined with geometric mean titer(GMT). Results 3499 serum samples were tested for HI antibody.The average level of HI antibody was 1:8.03.and 11.06%(387/3499)were sero-positive(HI antibody level≥1:40).In the group aged from 5 to 19 years,the level of HI antibody and the sero-positive rate were higber(HI antibody>1:8.9.sero-positive rate>12%). Conclusions The antibody levels in different groups were affected by age specific morbidity,and the higher antibody level of the school-age group was correlated with higher disease intensity in this population.The data showed that the herd immunity in Beijing was under the optimal level,but influenza A(H1N1)would probably become prevalent in the short coming future.