中华病理学杂志
中華病理學雜誌
중화병이학잡지
Chinese Journal of Pathology
2012年
5期
331-334
,共4页
侯震波%石怀银%梁霄%王新美
侯震波%石懷銀%樑霄%王新美
후진파%석부은%량소%왕신미
肉瘤,粒细胞%免疫组织化学%诊断,鉴别
肉瘤,粒細胞%免疫組織化學%診斷,鑒彆
육류,립세포%면역조직화학%진단,감별
Sarcoma,granulocytic%Immunohistochemistry%Diagnosis,differential
目的 探讨粒细胞肉瘤的临床病理学特征、诊断及鉴别诊断.方法 收集解放军总医院病理科和山东省淄博市中心医院病理科2004至2010年10例粒细胞肉瘤,进行光镜和免疫组织化学EnVision法染色并结合临床资料对其进行分析.结果 10例患者中年龄最小10岁,最大56岁,平均年龄35.8岁.其中男性6例,女性4例,男女比例为1.5∶1.4例在临床上以软组织肿块为首发症状.组织学上肿瘤呈浸润性生长,弥漫分布成片.细胞胞质少,细胞核圆形或不规则形,染色质细腻,核分裂象可见,亦可见幼稚的嗜酸性粒细胞散在分布.免疫组织化学染色肿瘤细胞表达髓过氧化物酶( MPO)、CD43、CD117、CD34和CD99.结论 粒细胞肉瘤各年龄组均可发病,男性多见.仅凭形态学易与淋巴瘤误诊,应与淋巴母细胞淋巴瘤、伯基特淋巴瘤、弥漫大B细胞淋巴瘤、尤其是发生于儿童的小圆细胞肿瘤及母细胞性浆细胞样树突细胞肿瘤相鉴别.免疫组织化学标记MPO、CD43、CD117、CD34、CD99和(或)细胞化学萘酚-ASD-氯乙酸酯酶染色结果有助于明确诊断及鉴别诊断.
目的 探討粒細胞肉瘤的臨床病理學特徵、診斷及鑒彆診斷.方法 收集解放軍總醫院病理科和山東省淄博市中心醫院病理科2004至2010年10例粒細胞肉瘤,進行光鏡和免疫組織化學EnVision法染色併結閤臨床資料對其進行分析.結果 10例患者中年齡最小10歲,最大56歲,平均年齡35.8歲.其中男性6例,女性4例,男女比例為1.5∶1.4例在臨床上以軟組織腫塊為首髮癥狀.組織學上腫瘤呈浸潤性生長,瀰漫分佈成片.細胞胞質少,細胞覈圓形或不規則形,染色質細膩,覈分裂象可見,亦可見幼稚的嗜痠性粒細胞散在分佈.免疫組織化學染色腫瘤細胞錶達髓過氧化物酶( MPO)、CD43、CD117、CD34和CD99.結論 粒細胞肉瘤各年齡組均可髮病,男性多見.僅憑形態學易與淋巴瘤誤診,應與淋巴母細胞淋巴瘤、伯基特淋巴瘤、瀰漫大B細胞淋巴瘤、尤其是髮生于兒童的小圓細胞腫瘤及母細胞性漿細胞樣樹突細胞腫瘤相鑒彆.免疫組織化學標記MPO、CD43、CD117、CD34、CD99和(或)細胞化學萘酚-ASD-氯乙痠酯酶染色結果有助于明確診斷及鑒彆診斷.
목적 탐토립세포육류적림상병이학특정、진단급감별진단.방법 수집해방군총의원병이과화산동성치박시중심의원병이과2004지2010년10례립세포육류,진행광경화면역조직화학EnVision법염색병결합림상자료대기진행분석.결과 10례환자중년령최소10세,최대56세,평균년령35.8세.기중남성6례,녀성4례,남녀비례위1.5∶1.4례재림상상이연조직종괴위수발증상.조직학상종류정침윤성생장,미만분포성편.세포포질소,세포핵원형혹불규칙형,염색질세니,핵분렬상가견,역가견유치적기산성립세포산재분포.면역조직화학염색종류세포표체수과양화물매( MPO)、CD43、CD117、CD34화CD99.결론 립세포육류각년령조균가발병,남성다견.부빙형태학역여림파류오진,응여림파모세포림파류、백기특림파류、미만대B세포림파류、우기시발생우인동적소원세포종류급모세포성장세포양수돌세포종류상감별.면역조직화학표기MPO、CD43、CD117、CD34、CD99화(혹)세포화학내분-ASD-록을산지매염색결과유조우명학진단급감별진단.
Objective To investigate the clinical and pathological features,differential diagnosis of granulocytic sarcoma. Methods The clinical manifestations, histopathological features,immunohistochemistry,treatment and prognosis were analyzed retrospectively in 10 cases of granulocytic sarcoma.Results The age of patients ranged from 10 to 56 years ( means =35.8 years).The male-to-female ratio was 1.5∶ 1.Histologically,the malignant cells of granulocytic sarcoma grew in a diffuse pattern.The cytoplasm was scanty,with eosinophilic fine granularity in some cells.The nuclei were round or focally irregular,and had finely dispersed chromatin.The mitotic figures were visible.Immunohistochemical stains for MPO,CD43,CD117,CD34 and CD99 were positive.Conclusions Granulocytic sarcoma can occur in patients of all ages with a male predominance.The diagnosis of granulocytic sarcoma is assisted by the cytochemical stain for naphthol-ASD-chloroacetate esterase and/or immunophenotypic analyses for MPO,CD43,CD117, CD34, CD99. These stains aid in the distinction of granulocytic sarcoma from:lymphoblastic lymphoma,Burkitt lymphoma,diffuse large B-cell lymphoma,small round cell tumours,particularly in children,and blastic plasmacytoid dendritic cell neoplasm.
