CAJ | 학술논문

目的:通过观察乙型肝炎患者血清中sICAM-1和sVCAM-1的水平及其与ALT、AST相关性, 探讨Ⅰ型超敏反应与乙型肝炎发病机制的关系.方法:应用酶联免疫吸附实验,检测45例乙型肝炎患者及15例对照组血清sICAM-1和sVCAM-1水平;应用全自动生化分析仪检测患者血清ALT和AST水平,并观察与sICAM-1和sVCAM-1的相关性.结果:①7例急性肝炎患者血清中sICAM-1和sVCAM-1含量明显高于正常对照组;②38例慢性肝炎患者血清中sICAM-1和sVCAM-1含量也明显高于正常对照组;③13例中度慢性肝炎患者的sICAM-1和sVCAM-1含量显著高于16例轻度慢性肝炎患者;④9例重度慢性肝炎患者的sICAM-1和sVCAM-1含量也明显高于轻度组和中度组;⑤sICAM-1水平与血清内ALT、AST含量呈显著正相关;⑥sVCAM-1水平与血清ALT、AST含量也呈显著正相关.总之,在以上几组中,急性乙型肝炎组的sICAM-1和sVCAM-1的升高最显著,并依次为慢性肝炎重度组、中度组和轻度组.结论:①急、慢性乙型肝炎患者血清中sICAM-1和sVCAM-1水平可反映肝损害程度;②检测急、慢性乙型肝炎患者血清sICAM-1和sVCAM-1水平,对判断患者的病情和预后有一定的参考价值;③作为Ⅰ型超敏反应性炎症的重要指标,sICAM-1和sVCAM-1可能参与了乙型肝炎的发病和肝细胞的免疫损伤过程.
목적:통과관찰을형간염환자혈청중sICAM-1화sVCAM-1적수평급기여ALT、AST상관성, 탐토Ⅰ형초민반응여을형간염발병궤제적관계.방법:응용매련면역흡부실험,검측45례을형간염환자급15례대조조혈청sICAM-1화sVCAM-1수평;응용전자동생화분석의검측환자혈청ALT화AST수평,병관찰여sICAM-1화sVCAM-1적상관성.결과:①7례급성간염환자혈청중sICAM-1화sVCAM-1함량명현고우정상대조조;②38례만성간염환자혈청중sICAM-1화sVCAM-1함량야명현고우정상대조조;③13례중도만성간염환자적sICAM-1화sVCAM-1함량현저고우16례경도만성간염환자;④9례중도만성간염환자적sICAM-1화sVCAM-1함량야명현고우경도조화중도조;⑤sICAM-1수평여혈청내ALT、AST함량정현저정상관;⑥sVCAM-1수평여혈청ALT、AST함량야정현저정상관.총지,재이상궤조중,급성을형간염조적sICAM-1화sVCAM-1적승고최현저,병의차위만성간염중도조、중도조화경도조.결론:①급、만성을형간염환자혈청중sICAM-1화sVCAM-1수평가반영간손해정도;②검측급、만성을형간염환자혈청sICAM-1화sVCAM-1수평,대판단환자적병정화예후유일정적삼고개치;③작위Ⅰ형초민반응성염증적중요지표,sICAM-1화sVCAM-1가능삼여료을형간염적발병화간세포적면역손상과정.