中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2011年
1期
37-40
,共4页
关玉峰%周卉%彭海颖%王顺钰%张萍%苏本利
關玉峰%週卉%彭海穎%王順鈺%張萍%囌本利
관옥봉%주훼%팽해영%왕순옥%장평%소본리
乙型肝炎表面抗体阳性%糖尿病%流行病学
乙型肝炎錶麵抗體暘性%糖尿病%流行病學
을형간염표면항체양성%당뇨병%류행병학
Positive HBsAb%Diabetes mellitus% Epidemiology
目的 研究乙型肝炎病毒表面抗体阳性率与2型糖尿病的相关性.方法 共纳入895名符合入组条件的50岁以上的健康体检者,对无糖尿病者进行75gOGTT检查.不同糖调节状态分组遵照WHO/1999标准进行.结果 895名受检者HBsAb阳性率50.4%.按性别分析HBsAb阳性与DM患病率之间的相关性,发现男性HBsAb状态与IGR之间没有统计学意义,女性HBsAb阳性者DM显著低于阴性者(15.7%VS 26.5%,χ2=11.342,P＜0.01).女性HBsAb阳性者的腰围、胰岛素抵抗指标及血压均低于阴性者,男性HBsAb阳性者没有发现类似趋势.结论 女性HBsAb阳性个体与胰岛素抵抗相关的代谢异常更少,乙型肝炎获得性免疫可能会降低糖尿病的发病风险.
目的 研究乙型肝炎病毒錶麵抗體暘性率與2型糖尿病的相關性.方法 共納入895名符閤入組條件的50歲以上的健康體檢者,對無糖尿病者進行75gOGTT檢查.不同糖調節狀態分組遵照WHO/1999標準進行.結果 895名受檢者HBsAb暘性率50.4%.按性彆分析HBsAb暘性與DM患病率之間的相關性,髮現男性HBsAb狀態與IGR之間沒有統計學意義,女性HBsAb暘性者DM顯著低于陰性者(15.7%VS 26.5%,χ2=11.342,P＜0.01).女性HBsAb暘性者的腰圍、胰島素牴抗指標及血壓均低于陰性者,男性HBsAb暘性者沒有髮現類似趨勢.結論 女性HBsAb暘性箇體與胰島素牴抗相關的代謝異常更少,乙型肝炎穫得性免疫可能會降低糖尿病的髮病風險.
목적 연구을형간염병독표면항체양성솔여2형당뇨병적상관성.방법 공납입895명부합입조조건적50세이상적건강체검자,대무당뇨병자진행75gOGTT검사.불동당조절상태분조준조WHO/1999표준진행.결과 895명수검자HBsAb양성솔50.4%.안성별분석HBsAb양성여DM환병솔지간적상관성,발현남성HBsAb상태여IGR지간몰유통계학의의,녀성HBsAb양성자DM현저저우음성자(15.7%VS 26.5%,χ2=11.342,P＜0.01).녀성HBsAb양성자적요위、이도소저항지표급혈압균저우음성자,남성HBsAb양성자몰유발현유사추세.결론 녀성HBsAb양성개체여이도소저항상관적대사이상경소,을형간염획득성면역가능회강저당뇨병적발병풍험.
Objective To study the association of diabetes with hepatitis B surface antibody in a population more than 50 years old. Methods 895 subjects without history of diabetes and diabetic symptoms underwent 75 g OGTT. Impaired glucose regulations were defined by WHO criteria in 1999. Results The number of subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and diabetes (DM) were 426 (47.5%), 262 (29.2%), and 207 (23.1%), respectively. There were 451 subjects with positive hepatitis virus B surface antibody (HBsAb) (50.4%), and 444 subjects with both negative HBsAg and negative HBsAb. The HBsAb positivity was not associated with glucose tolerant states in men, while the HBsAb positive women showed significant low prevalence of DM as compared to HBsAb negative women (15.7% vs 26.5%,χ2=11.342，P<0.003). In all the selected subjects the waist circumference, glucose resistant index, and blood pressures were significant lower in HBsAb positive women than in negative women (P＜0.05), while no significant differences of those parameters were found between HBsAb positive and negative men. Similar finding to above results were noticed in NGT subgroup both in men and women. Conclusion In this small scale epidemiological study, HBsAb positive women exhibits less insulin resistant and might have a lower risk to develope diabetes mellitus.
