国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2012年
8期
575-578
,共4页
吴春辉%司马国忠%张小军%严朝俊%樊永忠
吳春輝%司馬國忠%張小軍%嚴朝俊%樊永忠
오춘휘%사마국충%장소군%엄조준%번영충
脑出血%尿酸%危险因素%预后
腦齣血%尿痠%危險因素%預後
뇌출혈%뇨산%위험인소%예후
Cerebral Hemorrhage%Uric Acid%Risk Factors%Prognosis
目的 探讨血清尿酸水平与自发性脑出血患者近期临床转归的关系.方法 前瞻性连续纳入发病24 h内入院的自发性脑出血患者.入院次日检测血清尿酸水平；发病30天时应用改良Rankin量表(modified Rankin Scale,mRS)评估临床转归.将患者分为转归良好组(mRS评分≤2分)与转归不良组(mRS评分≥3分).结果 共纳入92例自发性脑出血患者,其中46例(50％)为男性,平均年龄(63±12)岁,基线格拉斯哥昏迷量表(Glasgow Coma Scale,GCS)评分为11分(9～12分).在发病后30天时进行的随访中,22例患者(23.9％)转归良好,70例患者(76.1％)转归不良.单变量分析显示,转归良好组GCS评分显著高于转归不良组[(13.85±2.80)分对(11.21±2.51)分；t=4.186,P=0.000],而血肿体积[(25.65 ±5.33)cm3对(34.60±8.97)cm3;t =4.430,P=0.000]和血清尿酸水平[(324.90±86.02) μmol/L对(458.63±72.77) μmol/L;t=7.193,P=0.000]显著低于转归不良组.多变量logistic回归分析显示,基线GCS评分低[优势比(odds ratio,OR)1.810,95％可信区间(confidence interval,CI) 1.382 ～2.382;P =0.001]、血肿体积较大(OR 1.156,95％ CI 1.045 ～ 1.280;P =0.005)和血清尿酸水平增高(OR2.127,95％ CI 1.055 ～4.287;P=0.035)是自发性脑出血患者近期临床转归不良的独立预测因素.结论 血清尿酸水平增高能预测自发性脑出血患者的近期临床转归不良.
目的 探討血清尿痠水平與自髮性腦齣血患者近期臨床轉歸的關繫.方法 前瞻性連續納入髮病24 h內入院的自髮性腦齣血患者.入院次日檢測血清尿痠水平；髮病30天時應用改良Rankin量錶(modified Rankin Scale,mRS)評估臨床轉歸.將患者分為轉歸良好組(mRS評分≤2分)與轉歸不良組(mRS評分≥3分).結果 共納入92例自髮性腦齣血患者,其中46例(50％)為男性,平均年齡(63±12)歲,基線格拉斯哥昏迷量錶(Glasgow Coma Scale,GCS)評分為11分(9～12分).在髮病後30天時進行的隨訪中,22例患者(23.9％)轉歸良好,70例患者(76.1％)轉歸不良.單變量分析顯示,轉歸良好組GCS評分顯著高于轉歸不良組[(13.85±2.80)分對(11.21±2.51)分；t=4.186,P=0.000],而血腫體積[(25.65 ±5.33)cm3對(34.60±8.97)cm3;t =4.430,P=0.000]和血清尿痠水平[(324.90±86.02) μmol/L對(458.63±72.77) μmol/L;t=7.193,P=0.000]顯著低于轉歸不良組.多變量logistic迴歸分析顯示,基線GCS評分低[優勢比(odds ratio,OR)1.810,95％可信區間(confidence interval,CI) 1.382 ～2.382;P =0.001]、血腫體積較大(OR 1.156,95％ CI 1.045 ～ 1.280;P =0.005)和血清尿痠水平增高(OR2.127,95％ CI 1.055 ～4.287;P=0.035)是自髮性腦齣血患者近期臨床轉歸不良的獨立預測因素.結論 血清尿痠水平增高能預測自髮性腦齣血患者的近期臨床轉歸不良.
목적 탐토혈청뇨산수평여자발성뇌출혈환자근기림상전귀적관계.방법 전첨성련속납입발병24 h내입원적자발성뇌출혈환자.입원차일검측혈청뇨산수평；발병30천시응용개량Rankin량표(modified Rankin Scale,mRS)평고림상전귀.장환자분위전귀량호조(mRS평분≤2분)여전귀불량조(mRS평분≥3분).결과 공납입92례자발성뇌출혈환자,기중46례(50％)위남성,평균년령(63±12)세,기선격랍사가혼미량표(Glasgow Coma Scale,GCS)평분위11분(9～12분).재발병후30천시진행적수방중,22례환자(23.9％)전귀량호,70례환자(76.1％)전귀불량.단변량분석현시,전귀량호조GCS평분현저고우전귀불량조[(13.85±2.80)분대(11.21±2.51)분；t=4.186,P=0.000],이혈종체적[(25.65 ±5.33)cm3대(34.60±8.97)cm3;t =4.430,P=0.000]화혈청뇨산수평[(324.90±86.02) μmol/L대(458.63±72.77) μmol/L;t=7.193,P=0.000]현저저우전귀불량조.다변량logistic회귀분석현시,기선GCS평분저[우세비(odds ratio,OR)1.810,95％가신구간(confidence interval,CI) 1.382 ～2.382;P =0.001]、혈종체적교대(OR 1.156,95％ CI 1.045 ～ 1.280;P =0.005)화혈청뇨산수평증고(OR2.127,95％ CI 1.055 ～4.287;P=0.035)시자발성뇌출혈환자근기림상전귀불량적독립예측인소.결론 혈청뇨산수평증고능예측자발성뇌출혈환자적근기림상전귀불량.
Objective To investigate the relationship between the serum uric acid (SUA) levels and the short-term clinical outcome in patients with spontaneous intracerebral hemorrhage.Methods Consecutive patients with spontaneous intracerebral hemorrhage admitted within 24 hours after onset were prospectively included.SUA levels was measured on the next morning after admission.Modified Rankin Scale (mRS) was used to ascertain clinical outcome at 30 days.The patients were divided into a good outcome group (mRS＜2) and poor outcome group (mRS≥3).Results A total of 92 patients with spontaneous intracerebral hemorrhage were included,and 46 of them (50％) were men,the mean age was 63 ± 12 years.At 30 days after onset,22 patients (23.9％) had a good outcome and 70 patients (76.1％) had a poor outcome.Univariate analysis showed that the Glasgow Come Scale (GCS) score in the good outcome group was significantly higher than that in the poor outcome group (13.85 ± 2.80 vs.11.21 ± 2.51; t=4.186,P=0.000),while hematoma volume (25.65 ±5.33 cm3 vs.34.60± 8.97 cm3,t=4.430,P=0.000) and SUA levels (324.90± 86.02 μmol/L vs.458.63 ±72.77 μmol/L; t =7.193,P =0.000) were significantly lower than those in the poor outcome group.Multivariate logistic regression analysis showed that the lower GCS score (odds ratio [OR]1.810,95％ confidence interval [CI]1.382-2.382; P =0.001),larger hematoma volume (OR 1.156,95％ CI 1.045-1.280; P=0.005) and higher SUA levels (OR 2.127,95％ CI 1.055-4.287; P=0.035) were the independent predictive factors for the short-term clinical outcome in patients with spontaneous intracerebral hemorrhage.Conclusions The increased SUA levels may predict the poor short-term clinical outcome in patients with spontaneous intracerebral hemorrhage.
