中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2009年
12期
890-895
,共6页
赵新菊%陈江华%罗琼%余学清%李英%徐金生%黄颂敏%王力宁%黄雯%王梅%马迎春%左力%许国宾%王海燕
趙新菊%陳江華%囉瓊%餘學清%李英%徐金生%黃頌敏%王力寧%黃雯%王梅%馬迎春%左力%許國賓%王海燕
조신국%진강화%라경%여학청%리영%서금생%황송민%왕력저%황문%왕매%마영춘%좌력%허국빈%왕해연
肾小球滤过率%大陆人口群%肾功能不全%慢性%种族系数%肾小球滤过率估计公式
腎小毬濾過率%大陸人口群%腎功能不全%慢性%種族繫數%腎小毬濾過率估計公式
신소구려과솔%대륙인구군%신공능불전%만성%충족계수%신소구려과솔고계공식
Glomerular filtration rate%Continental population groups%Renal insufficiency%chronic%Racial coefficient%GFR estimating equation
目的 探讨肾小球滤过率(GFR)估计公式中种族系数是否会受到不同研究中GFR测量值分布不同的影响.方法 本研究包括MDRD研究中的1405例白种美籍患者,321例非洲裔美国患者和中国eGFR调查研究中的684例中国CKD患者.首先,白种美籍患者和中国CKD患者的数据库合并,将GFR、年龄(age)、血肌酐(Pcr)进行log转换.令log[GFR]为应变量,log[Pcr]、log[age]、性别和种族为自变量进行线性回归,计算小加权的种族系数(uRC);然后按照白种美籍患者的CKD各期比例子中国CKD患者GFR测量值进行加权,使之与白种美籍患者的CKD分期分布一致.计算加权后的种族系数(wRC).白种美籍患者和非裔美籍患者的数据合库,使非裔美籍患者的CKD分期分布分别与中国患者和向种美籍患者一致.计算相应的种族系数.结果 中国患者的uRC为1.197(1.180～1.211),wRC为1.130(1.117-1.143).与中国患者和白种美籍患者CKD分期一致后,非裔美籍患者的种族系数则分别为1.205(1.191～1.219)和1.233(1.219-1.247).结论 用于开发GFR公式的人群的GFR测量值的分布不同可以导致种族系数的差异.为得到真正的种族系数需要国际合作,应用相同的GFR测量方法和Pcr测量方法,同时也需要GFR测量值分布一致.
目的 探討腎小毬濾過率(GFR)估計公式中種族繫數是否會受到不同研究中GFR測量值分佈不同的影響.方法 本研究包括MDRD研究中的1405例白種美籍患者,321例非洲裔美國患者和中國eGFR調查研究中的684例中國CKD患者.首先,白種美籍患者和中國CKD患者的數據庫閤併,將GFR、年齡(age)、血肌酐(Pcr)進行log轉換.令log[GFR]為應變量,log[Pcr]、log[age]、性彆和種族為自變量進行線性迴歸,計算小加權的種族繫數(uRC);然後按照白種美籍患者的CKD各期比例子中國CKD患者GFR測量值進行加權,使之與白種美籍患者的CKD分期分佈一緻.計算加權後的種族繫數(wRC).白種美籍患者和非裔美籍患者的數據閤庫,使非裔美籍患者的CKD分期分佈分彆與中國患者和嚮種美籍患者一緻.計算相應的種族繫數.結果 中國患者的uRC為1.197(1.180～1.211),wRC為1.130(1.117-1.143).與中國患者和白種美籍患者CKD分期一緻後,非裔美籍患者的種族繫數則分彆為1.205(1.191～1.219)和1.233(1.219-1.247).結論 用于開髮GFR公式的人群的GFR測量值的分佈不同可以導緻種族繫數的差異.為得到真正的種族繫數需要國際閤作,應用相同的GFR測量方法和Pcr測量方法,同時也需要GFR測量值分佈一緻.
목적 탐토신소구려과솔(GFR)고계공식중충족계수시부회수도불동연구중GFR측량치분포불동적영향.방법 본연구포괄MDRD연구중적1405례백충미적환자,321례비주예미국환자화중국eGFR조사연구중적684례중국CKD환자.수선,백충미적환자화중국CKD환자적수거고합병,장GFR、년령(age)、혈기항(Pcr)진행log전환.령log[GFR]위응변량,log[Pcr]、log[age]、성별화충족위자변량진행선성회귀,계산소가권적충족계수(uRC);연후안조백충미적환자적CKD각기비례자중국CKD환자GFR측량치진행가권,사지여백충미적환자적CKD분기분포일치.계산가권후적충족계수(wRC).백충미적환자화비예미적환자적수거합고,사비예미적환자적CKD분기분포분별여중국환자화향충미적환자일치.계산상응적충족계수.결과 중국환자적uRC위1.197(1.180～1.211),wRC위1.130(1.117-1.143).여중국환자화백충미적환자CKD분기일치후,비예미적환자적충족계수칙분별위1.205(1.191～1.219)화1.233(1.219-1.247).결론 용우개발GFR공식적인군적GFR측량치적분포불동가이도치충족계수적차이.위득도진정적충족계수수요국제합작,응용상동적GFR측량방법화Pcr측량방법,동시야수요GFR측량치분포일치.
Objective To illustrate if the racial coefficient (Rc) be biased by different reference GFR (rGFR) distribution among studies. Methods 1405 white and 321 African American participants in MDRD study and 684 chronic kidney disease(CKD)patients in Chinese eGFR Investigation Study were included.Firstly.the unweighted datasets of white and Chinese were stacked together.rGFR,age and plasma creatinine (Pcr) were log transformed.Linear regression model was constructed using log transformed rGFR as dependent,gender,race and log transformed Pcr and age as independent.Unweighted RC (uRC) for Chinese was calculated.Then.the Chinese CKD distribution of rGFR was weighted to be the same as that in White American.and weighted RC (wRC)for Chinese was calculated.The cases of White.and African-American were stacked together.The cases of African-American were weighted to make the rGFR distribution the same as that in White-American and Chinese population respectively,and RCs for African-American were calculated. Resuits The uRC for Chinese was 1.197(1.180-1.211)and the wRC was 1.130 (1.117-1.143).The two RCs did not overlap with each other.The RCs for African-American were 1.205(1.19-1.219)and 1.233(1.219-1.247)respectively. Conclusions The RCs were influenced by the difference of rGFR distribution.To find out the real RC.an intemational collaborative study iS needed,with the same rGFR measure method.strict control of Pcr measurement,and the same rGFR distribution.
