中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2009年
47期
3341-3345
,共5页
张蓉%宋燕%高维娇%张询%佐晶%雷呈志%王晔
張蓉%宋燕%高維嬌%張詢%佐晶%雷呈誌%王曄
장용%송연%고유교%장순%좌정%뢰정지%왕엽
宫颈肿瘤%预后%P53%COX2%CD44V6
宮頸腫瘤%預後%P53%COX2%CD44V6
궁경종류%예후%P53%COX2%CD44V6
Cervix neoplasms%Prognosis%P53%COX2%CD44V6
目的 探讨早期宫颈癌脉管瘤栓(LVSI)与各临床病理参数的关系及P53、COX2、CD44V6在早期官颈癌中的表达及与预后的关系.方法 对象为早期宫颈癌脉管瘤栓阳性44例,对照组为相对应的脉管瘤栓阴性44例官颈癌患者.采用免疫组织化学方法 监测P53、COX2、CD44V6的表达情况,分析脉管瘤栓、P53、COX2、CD44V6与临床病理参数之间的关系及对预后的影响.结果 脉管瘤栓阳性与淋巴结转移、深肌层受侵明显相关,脉管瘤栓阳性、阴性者5年无瘤存活分别为68.9%、94.7%.P<0.01,总存活率为70.2%、100%,P<0.01.COX2与临床期别、肿瘤大小有相关性,P53、CD44V6与临床参数之间无相关性.P53、COX2、CD44V6阳性患者生存时间短于阴性患者,特别是三者均阳性患者无瘤存活时间(DFS)、总存活时间(OS)分别为60.0,67.3个月,三者均阴性患者分别为73.6,91.3个月,但差异无统计学意义.结论 早期官颈鳞癌中脉管瘤栓阳性与淋巴结转移、深肌层受侵相关,与5年无瘤存活、总存活负相关,COX2与肿瘤大小、临床期别相关,P53、CD44V6与临床各因素无关,P53、COX2、CD44V6阳性者存活期短于阴性者.
目的 探討早期宮頸癌脈管瘤栓(LVSI)與各臨床病理參數的關繫及P53、COX2、CD44V6在早期官頸癌中的錶達及與預後的關繫.方法 對象為早期宮頸癌脈管瘤栓暘性44例,對照組為相對應的脈管瘤栓陰性44例官頸癌患者.採用免疫組織化學方法 鑑測P53、COX2、CD44V6的錶達情況,分析脈管瘤栓、P53、COX2、CD44V6與臨床病理參數之間的關繫及對預後的影響.結果 脈管瘤栓暘性與淋巴結轉移、深肌層受侵明顯相關,脈管瘤栓暘性、陰性者5年無瘤存活分彆為68.9%、94.7%.P<0.01,總存活率為70.2%、100%,P<0.01.COX2與臨床期彆、腫瘤大小有相關性,P53、CD44V6與臨床參數之間無相關性.P53、COX2、CD44V6暘性患者生存時間短于陰性患者,特彆是三者均暘性患者無瘤存活時間(DFS)、總存活時間(OS)分彆為60.0,67.3箇月,三者均陰性患者分彆為73.6,91.3箇月,但差異無統計學意義.結論 早期官頸鱗癌中脈管瘤栓暘性與淋巴結轉移、深肌層受侵相關,與5年無瘤存活、總存活負相關,COX2與腫瘤大小、臨床期彆相關,P53、CD44V6與臨床各因素無關,P53、COX2、CD44V6暘性者存活期短于陰性者.
목적 탐토조기궁경암맥관류전(LVSI)여각림상병리삼수적관계급P53、COX2、CD44V6재조기관경암중적표체급여예후적관계.방법 대상위조기궁경암맥관류전양성44례,대조조위상대응적맥관류전음성44례관경암환자.채용면역조직화학방법 감측P53、COX2、CD44V6적표체정황,분석맥관류전、P53、COX2、CD44V6여림상병리삼수지간적관계급대예후적영향.결과 맥관류전양성여림파결전이、심기층수침명현상관,맥관류전양성、음성자5년무류존활분별위68.9%、94.7%.P<0.01,총존활솔위70.2%、100%,P<0.01.COX2여림상기별、종류대소유상관성,P53、CD44V6여림상삼수지간무상관성.P53、COX2、CD44V6양성환자생존시간단우음성환자,특별시삼자균양성환자무류존활시간(DFS)、총존활시간(OS)분별위60.0,67.3개월,삼자균음성환자분별위73.6,91.3개월,단차이무통계학의의.결론 조기관경린암중맥관류전양성여림파결전이、심기층수침상관,여5년무류존활、총존활부상관,COX2여종류대소、림상기별상관,P53、CD44V6여림상각인소무관,P53、COX2、CD44V6양성자존활기단우음성자.
Objective To investigate the relationship between lymph vascular space invasion (LVSI) and various clinicopathologic factors in early-stage cervical squamous carcinoma; to explore the expression of P53, COX2 and CD44V6 in early stage squamous carcinoma of cervix and its relationship with prognosis. Methods A case-controlled study was conducted to compare LVSI positive group (n = 44) in early stage squamous carcinoma of cervix with LVSI negative group ( n = 44 ). Expression of P53 , COX2 and CD44V6 were evaluated by immunohistochemical method to analyze the relationship between LVSI, P53, COX2 and CD44V6 and various clinicopathologic factors and to investigate their prognostic influences. Results LVSI positive was correlated with lymph node metastasis and deep stromal invasion. The 5-year disease-free survival was 68. 9% in LVSI positive group versus 94. 7% in LVSI negative group (P<0. 01). And the 5-year overall survival was 70.2% in LVSI positive group versus 100% in LVSI negative group (P <0. 01) with a significant difference. COX2 was correlated with clinical stage and tumor volume while there was no correlation with P53, CD44V6 and clinical factors. The overall survival of P53, COX2 and CD44V6 positive cases were significantly shorter than that of negative ones, especially in constant positive cases of 3 markers ( disease-free survival 60. 0 months shorter than constant negative cases with an overall survival of 91.3 months, but there was no significant difference). Conclusion LVSI is correlated with lymph node metastasis and deep stromal invasion in the early-stage squamous carcinoma of cervix while it is negatively correlated with disease-free survival and overall survival. COX2 is correlated with clinical stage and tumor volume. Furthermore P53 and CD44V6 are not correlated with clinical factors. The overall survival of P53, COX2 and CD44V6 positive cases are significantly shorter than that of negative ones.
