CAJ | 학술논문

研究组织蛋白酶K(cathepsin K, CTSK)在肥胖症患者脂肪组织中的表达及其在脂肪细胞分化中所起的作用.采用半定量RT-PCR及Western-blot分析显示肥胖组脂肪组织CTSK水平显著高于对照组,其表达随脂肪细胞分化成熟而逐渐增加.脂肪组织CTSK水平是肥胖症和脂质生成的一个较为敏感的标志物.
연구조직단백매K(cathepsin K, CTSK)재비반증환자지방조직중적표체급기재지방세포분화중소기적작용.채용반정량RT-PCR급Western-blot분석현시비반조지방조직CTSK수평현저고우대조조,기표체수지방세포분화성숙이축점증가.지방조직CTSK수평시비반증화지질생성적일개교위민감적표지물.
Semi-quantitative RT-PCR and immunoblotting analyses were used to investigate the expression of CTSK and its role in 3T3-L1 cell differentiation.The expression of CTSK gene was remarkably higher in obese patients than in the control group,and was increased gradually during adipocyte differentiation.CTSK gene is possibly involved in the adipocyte differentiation and the onset of obesity.