CAJ | 학술논문

以不同比例的羟丙甲纤维素(HPMC)为骨架材料,制备中成药玉叶清火缓释片.通过精确的HPLC法监测玉叶清火缓释片中主要成分穿心莲内酯的释出量,并计算其体外释放度.结果表明玉叶清火普通片在1.5 h段,累积释出率为49.47%±2.21(-x±s),同时段的10%和20%HPPMC玉叶清火缓释片的累积释出率仅为41.94%±1.53和29.50%±2.51(P＜0.01).按回归曲线计算累积释放率50%及95%时所需时间:玉叶清火普通片为1.52 h和3.89 h;10%和20%HPMC玉叶清火缓释片则分别为:2.07 h,5.98 h及3.13 h,8.48 h.新型中药制剂10%和20%HPMC玉叶清火缓释片的体外释出率显著低于同时段的玉叶清火普通片(P＜0.01),实际测定值与计算结果相符.所研制的缓释片的缓释效果良好.
이불동비례적간병갑섬유소(HPMC)위골가재료,제비중성약옥협청화완석편.통과정학적HPLC법감측옥협청화완석편중주요성분천심련내지적석출량,병계산기체외석방도.결과표명옥협청화보통편재1.5 h단,루적석출솔위49.47%±2.21(-x±s),동시단적10%화20%HPPMC옥협청화완석편적루적석출솔부위41.94%±1.53화29.50%±2.51(P＜0.01).안회귀곡선계산루적석방솔50%급95%시소수시간:옥협청화보통편위1.52 h화3.89 h;10%화20%HPMC옥협청화완석편칙분별위:2.07 h,5.98 h급3.13 h,8.48 h.신형중약제제10%화20%HPMC옥협청화완석편적체외석출솔현저저우동시단적옥협청화보통편(P＜0.01),실제측정치여계산결과상부.소연제적완석편적완석효과량호.
After Yujie Qihuo general and sustained-release tablets were made, high performance liquid chromatogram (HPLC) were used to investigate the main effective ingredient andrographolide concentration in the release medium for their releasing rates. The results showed that the cumulative releasing rate of 10% and 20% Yujie Qihuo HPMC sustained-release tablets were 41.94%±1.53 (-x±s) and 29.50%±2.51 at 1.5 hours respectively and significantly lower than the rate of Yujie Qihuo general tablet which was 49.47% ±2.21, (P＜0.01). Both HPMC sustained-release tablets took much longer time to reach 50% and 95% of cumulative releasing rates comparing with Yujie Qihuo general tablet (P＜0.01). So the new types of 10% and 20% Yujie Qihuo HPMC sustained-release tablets have slower releasing rates than that of the general tablet significantly.