CAJ | 학술논문

背景与目的:骨外Ewing肉瘤是指原发于骨组织外的尤文氏肉瘤,发病率低.本研究旨在通过对骨外Ewing肉瘤进行临床分析,探讨其临床特点、诊断和治疗方法.方法:回顾分析中山大学肿瘤防治中心1995年1月～2007年7月确诊并接受治疗的18例骨外Ewing肉瘤患者的临床资料,同时结合文献加以讨论.结果:18例患者中,男性13例,女性5例;年龄8个月～60岁,中位年龄17岁,其中12例患者(66.7%)年龄为5～25岁.肿瘤原发于下肢8例(44.4%),椎旁5例(27.8%),胸壁2例(11.1%).临床症状表现为肿块16例(88.9%).16例患者接受了综合治疗,2例接受了非综合治疗.1、3、5年生存率分别为82.4%、64.2%和32.1%.单因素分析显示有无远处转移及治疗模式与预后相关.结论:该肿瘤好发于青少年,主要表现为局部肿块,采取积极的综合治疗方案是主要治疗方法,预后与有无远处转移及治疗模式相关.
배경여목적:골외Ewing육류시지원발우골조직외적우문씨육류,발병솔저.본연구지재통과대골외Ewing육류진행림상분석,탐토기림상특점、진단화치료방법.방법:회고분석중산대학종류방치중심1995년1월～2007년7월학진병접수치료적18례골외Ewing육류환자적림상자료,동시결합문헌가이토론.결과:18례환자중,남성13례,녀성5례;년령8개월～60세,중위년령17세,기중12례환자(66.7%)년령위5～25세.종류원발우하지8례(44.4%),추방5례(27.8%),흉벽2례(11.1%).림상증상표현위종괴16례(88.9%).16례환자접수료종합치료,2례접수료비종합치료.1、3、5년생존솔분별위82.4%、64.2%화32.1%.단인소분석현시유무원처전이급치료모식여예후상관.결론:해종류호발우청소년,주요표현위국부종괴,채취적겁적종합치료방안시주요치료방법,예후여유무원처전이급치료모식상관.
Background and Objective: Extraskeletal Ewing's sarcoma(EES)is a rare,rapidly growing,round-cell,malignant tumor that can develop in the soft tissues at any location.This study was to analyze the clinical features,diagnosis and treatment of EES.Methods: Clinical data of 18patients with EES,treated at Sun Yat-sun University Cancer Center between1995 and 2007,were analyzed.Reults: Of the 18 patients,13 were male and 8 were female,aged from 8 months to 60 years.Twelve(66.7%)patients were between 5-25 years of age.Eight(44.4%)patients had tumors originated from low extremities.Sixteen patients had masses at their first visit.Sixteen patients were treated by the combined modality therapy,and 2 patients were treated by the single modality therapy.The 1-,3-and 5-year actuarial survival rates were 82.4%,64.2% and 32.1%,respectively.The presence of metastatic disease at the time of diagnosis and the mode of treatment were prognostic factors.Conclusions: EES is common in adolescent.It often manifests as a localized mass.The combined modality therapy is recommended for this disease.The presence of metastatic disease at the time of diagnosis and the mode of treatment are prognostic factors.