癌症
癌癥
암증
CHINESE JOURNAL OF CANCER
2010年
4期
462-467
,共6页
骨外Ewing肉瘤%临床特征%诊断%治疗
骨外Ewing肉瘤%臨床特徵%診斷%治療
골외Ewing육류%림상특정%진단%치료
Extraosseous Ewing's sarcoma%clinical feature%diagnosis%treatment
背景与目的:骨外Ewing肉瘤是指原发于骨组织外的尤文氏肉瘤,发病率低.本研究旨在通过对骨外Ewing肉瘤进行临床分析,探讨其临床特点、诊断和治疗方法.方法:回顾分析中山大学肿瘤防治中心1995年1月~2007年7月确诊并接受治疗的18例骨外Ewing肉瘤患者的临床资料,同时结合文献加以讨论.结果:18例患者中,男性13例,女性5例;年龄8个月~60岁,中位年龄17岁,其中12例患者(66.7%)年龄为5~25岁.肿瘤原发于下肢8例(44.4%),椎旁5例(27.8%),胸壁2例(11.1%).临床症状表现为肿块16例(88.9%).16例患者接受了综合治疗,2例接受了非综合治疗.1、3、5年生存率分别为82.4%、64.2%和32.1%.单因素分析显示有无远处转移及治疗模式与预后相关.结论:该肿瘤好发于青少年,主要表现为局部肿块,采取积极的综合治疗方案是主要治疗方法,预后与有无远处转移及治疗模式相关.
揹景與目的:骨外Ewing肉瘤是指原髮于骨組織外的尤文氏肉瘤,髮病率低.本研究旨在通過對骨外Ewing肉瘤進行臨床分析,探討其臨床特點、診斷和治療方法.方法:迴顧分析中山大學腫瘤防治中心1995年1月~2007年7月確診併接受治療的18例骨外Ewing肉瘤患者的臨床資料,同時結閤文獻加以討論.結果:18例患者中,男性13例,女性5例;年齡8箇月~60歲,中位年齡17歲,其中12例患者(66.7%)年齡為5~25歲.腫瘤原髮于下肢8例(44.4%),椎徬5例(27.8%),胸壁2例(11.1%).臨床癥狀錶現為腫塊16例(88.9%).16例患者接受瞭綜閤治療,2例接受瞭非綜閤治療.1、3、5年生存率分彆為82.4%、64.2%和32.1%.單因素分析顯示有無遠處轉移及治療模式與預後相關.結論:該腫瘤好髮于青少年,主要錶現為跼部腫塊,採取積極的綜閤治療方案是主要治療方法,預後與有無遠處轉移及治療模式相關.
배경여목적:골외Ewing육류시지원발우골조직외적우문씨육류,발병솔저.본연구지재통과대골외Ewing육류진행림상분석,탐토기림상특점、진단화치료방법.방법:회고분석중산대학종류방치중심1995년1월~2007년7월학진병접수치료적18례골외Ewing육류환자적림상자료,동시결합문헌가이토론.결과:18례환자중,남성13례,녀성5례;년령8개월~60세,중위년령17세,기중12례환자(66.7%)년령위5~25세.종류원발우하지8례(44.4%),추방5례(27.8%),흉벽2례(11.1%).림상증상표현위종괴16례(88.9%).16례환자접수료종합치료,2례접수료비종합치료.1、3、5년생존솔분별위82.4%、64.2%화32.1%.단인소분석현시유무원처전이급치료모식여예후상관.결론:해종류호발우청소년,주요표현위국부종괴,채취적겁적종합치료방안시주요치료방법,예후여유무원처전이급치료모식상관.
Background and Objective: Extraskeletal Ewing's sarcoma(EES)is a rare,rapidly growing,round-cell,malignant tumor that can develop in the soft tissues at any location.This study was to analyze the clinical features,diagnosis and treatment of EES.Methods: Clinical data of 18patients with EES,treated at Sun Yat-sun University Cancer Center between1995 and 2007,were analyzed.Reults: Of the 18 patients,13 were male and 8 were female,aged from 8 months to 60 years.Twelve(66.7%)patients were between 5-25 years of age.Eight(44.4%)patients had tumors originated from low extremities.Sixteen patients had masses at their first visit.Sixteen patients were treated by the combined modality therapy,and 2 patients were treated by the single modality therapy.The 1-,3-and 5-year actuarial survival rates were 82.4%,64.2% and 32.1%,respectively.The presence of metastatic disease at the time of diagnosis and the mode of treatment were prognostic factors.Conclusions: EES is common in adolescent.It often manifests as a localized mass.The combined modality therapy is recommended for this disease.The presence of metastatic disease at the time of diagnosis and the mode of treatment are prognostic factors.