CAJ | 학술논문

目前发展疟疾疫苗仍然是防治和消灭疟疾感染的重要手段,红内期是疟原虫致病并引起临床症状的主要时期,发展有效的红内期疫苗不仅能减轻临床症状,还可降低血中配子体数量从而起到阻断传播作用.本文就目前红内期亚单位疫苗候选抗原及全虫疫苗的研究现状作一综述.
목전발전학질역묘잉연시방치화소멸학질감염적중요수단,홍내기시학원충치병병인기림상증상적주요시기,발전유효적홍내기역묘불부능감경림상증상,환가강저혈중배자체수량종이기도조단전파작용.본문취목전홍내기아단위역묘후선항원급전충역묘적연구현상작일종술.
A key tool for control and elimination of malaria is an effective vaccine.The pathology and clinical symptoms of malaria are associated with the blood stages of the parasite's life cycle.The development of blood stage vaccines can reduce or clear the clinical symptoms and reduce the transmission through the mosquito vector.The review focuses only on advantages and challenges of candidate antigens of blood-stage subunit vaccine and whole blood-stage parasites vaccine.