国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2011年
2期
86-90
,共5页
海马CA1区%自发放电%放电频率%放电模式
海馬CA1區%自髮放電%放電頻率%放電模式
해마CA1구%자발방전%방전빈솔%방전모식
Hippocampal CA1%Spontaneous firing%Spiking frequency%Burst model
目的 分析在胞外钾离子浓度[K+]0和离子通道电导变化的情况下,海马CA1区单个神经元自发放电频率和放电模式的变化.方法 对 Warman等提出的模型进行改进,应用计算机软件MATLAB建立一个包括16个房室的海马CA1区锥体细胞单个神经元的电缆模型.其中树突室不含有源通道,而胞体室含有5个离子通道(INa、INap、IDR、IA、IM),该模型不包括钙电流和由钙浓度调节的钾电流(ICa、ICT、IAHP).结果 仿真结果表明,海马CA1区神经元产生自发周期的放电行为;随着[K+]0的增加,钠电导的增加和钾电导的减少,放电频率增加;单个神经元的自发放电行为以单峰或者每个簇内含有2个或3个峰的形式出现.结论 神经元自发放电频率和放电模式的变化与[K+]0以及离子通道电导等因素有关.
目的 分析在胞外鉀離子濃度[K+]0和離子通道電導變化的情況下,海馬CA1區單箇神經元自髮放電頻率和放電模式的變化.方法 對 Warman等提齣的模型進行改進,應用計算機軟件MATLAB建立一箇包括16箇房室的海馬CA1區錐體細胞單箇神經元的電纜模型.其中樹突室不含有源通道,而胞體室含有5箇離子通道(INa、INap、IDR、IA、IM),該模型不包括鈣電流和由鈣濃度調節的鉀電流(ICa、ICT、IAHP).結果 倣真結果錶明,海馬CA1區神經元產生自髮週期的放電行為;隨著[K+]0的增加,鈉電導的增加和鉀電導的減少,放電頻率增加;單箇神經元的自髮放電行為以單峰或者每箇簇內含有2箇或3箇峰的形式齣現.結論 神經元自髮放電頻率和放電模式的變化與[K+]0以及離子通道電導等因素有關.
목적 분석재포외갑리자농도[K+]0화리자통도전도변화적정황하,해마CA1구단개신경원자발방전빈솔화방전모식적변화.방법 대 Warman등제출적모형진행개진,응용계산궤연건MATLAB건립일개포괄16개방실적해마CA1구추체세포단개신경원적전람모형.기중수돌실불함유원통도,이포체실함유5개리자통도(INa、INap、IDR、IA、IM),해모형불포괄개전류화유개농도조절적갑전류(ICa、ICT、IAHP).결과 방진결과표명,해마CA1구신경원산생자발주기적방전행위;수착[K+]0적증가,납전도적증가화갑전도적감소,방전빈솔증가;단개신경원적자발방전행위이단봉혹자매개족내함유2개혹3개봉적형식출현.결론 신경원자발방전빈솔화방전모식적변화여[K+]0이급리자통도전도등인소유관.
Objective To analyse the variability of spontaneous firing frequencies and firing patterns of a Hippocampal CA1 neuron with the changes of extracellular potassium concentration[K+]0 and ion channel conductance.Methods A 16-compartment cable model of a Hippocampal CA1 neuron was developed based on the Warman model with computer software MATLAB.The dendrites contained no active channels,while five active channels (INa,INap,IDR,IA,IM)were contained in soma.In the model,the calcium currents and potassium currents(ICm,,ICT and IAHP) regulated by calcium concentration were not included.Results Simulation results showed that the neuron could generate periodicspontaneous firing activity.The spiking frequency increased with the increasing of[K+]0 and sodium conductance and decreasing of potassium conductance.Spontaneous single neuron activity appeared in singlet or in grouped bursts of two or three spikes.Conclusion The variability of spontaneous firing frequencies and firing patterns of single neuron are relevant to[K+]0 and ion channel conductance.
