CAJ | 학술논문

目的观察帕罗西汀治疗卒中后抑郁焦虑症状的疗效、安全性,及其对肢体功能康复的影响.方法 88例急性脑卒中后抑郁焦虑患者按数字表法随机分为帕罗西汀组42例和对照组46例,对照组给予脑血管病常规治疗,帕罗西汀组在对照组治疗的基础上给予帕罗西汀20 mg,1次/d,分别于治疗后4、6周末进行汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和神经功能缺损、生活能力状态等评定.结果治疗后4、6周,两组治疗后HAMD、HAMA量表评分、神经功能缺损评分及BI指数均较治疗前明显改善(均P＜0.05),帕罗西汀组较对照组改善更为明显(t=3.521、2.604、2.773、2.683、3.637、3.781、3.042、2.913,均P＜0.05).未发生严重不良反应.结论帕罗西汀治疗脑卒中后抑郁焦虑疗效可靠,无明显不良反应,且能加速肢体功能康复.
목적 관찰파라서정치료졸중후억욱초필증상적료효、안전성,급기대지체공능강복적영향.방법 88례급성뇌졸중후억욱초필환자안수자표법수궤분위파라서정조42례화대조조46례,대조조급여뇌혈관병상규치료,파라서정조재대조조치료적기출상급여파라서정20 mg,1차/d,분별우치료후4、6주말진행한밀이돈억욱량표(HAMD)、한밀이돈초필량표(HAMA)화신경공능결손、생활능력상태등평정.결과 치료후4、6주,량조치료후HAMD、HAMA량표평분、신경공능결손평분급BI지수균교치료전명현개선(균P＜0.05),파라서정조교대조조개선경위명현(t=3.521、2.604、2.773、2.683、3.637、3.781、3.042、2.913,균P＜0.05).미발생엄중불량반응.결론 파라서정치료뇌졸중후억욱초필료효가고,무명현불량반응,차능가속지체공능강복.
Objective To study the efficiency,safety,and its impact on the functional rehabilitation of the selective 5-serotonin reuptake inhibitor(SSRI) drugs paroxetine in treatment patients with poststroke depression and anxiety.Methods The acute stroke patients at our Neurology department and old-age cadres department were selected,in which have 88 cases of poststroke patients with depression and anxiety,which were divided into paroxetine group and the control group.Paroxetine group was given Seroxat 20 ng,1 time/d + conventional treatment of cerebrovascular disease.The control group was gaven conventional treatment of cerebrovascular disease only.After 4 weeks,6 weeks of treatment,we assessed Hamilton Depression Rating Scale(HAMD),Hamilton Anxiety Scale(HAMA),neurological deficit and the state of living ability were assessed.Results There were significant differences in improvenent of depression and anxiety,neurological deficit and the capacity of the state of life between the Paroxetine group and the control group the control group of 4 weeks treatment compared with before treatment(all P＜0.05);Compared with before treatment,the control group of 6 weeks treatment compared with before treatment(all P＜0.05);Paroxetine group of 4 weeks treatment compared with before treatment(all P＜0.05);Paroxetine group of 6 weeks treatment compared with before treatment(all P＜0.05),and Paroxetine group control is obvious Improved(all P＜0.05).Conclusion Using Paroxetine to treat poststroke patients with depression and anxiety,not only could significantly improve symptoms of depression and anxiety,but also speed up the rehabilitation of limb function,efficacy reliable,and had no significant adverse reactions.So,it was an ideal medcine for poststroke patients with depression and anxiety.