中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2011年
6期
649-652
,共4页
刘桂玲%赵丽娜%楮丽敏%额尔敦高娃%郝玲
劉桂玲%趙麗娜%楮麗敏%額爾敦高娃%郝玲
류계령%조려나%저려민%액이돈고왜%학령
妊娠期高血压疾病%新生儿%脐血%血脂
妊娠期高血壓疾病%新生兒%臍血%血脂
임신기고혈압질병%신생인%제혈%혈지
Pregnancy-induced hypertension%Neonate%Cord Blood%Blood lipid
目的 探讨妊娠期高血压疾病(PIH)对新生儿血脂的影响.方法 PIH母儿80例,按第6版妇产科学PIH诊断标准分为3组:妊娠期高血压疾病组30例、子痫前期轻度组30例、子痫前期重度组20例,另设同期正常对照组40名,采用全自动生化分析仪测定脐血甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、ApoA及脂蛋白(LPA).结果 (1)妊娠期高血压疾病组、子痫前期轻度组、子痫前期重度组、正常对照组新生儿脐血TG的浓度分别为(0.25±0.10)、(0.33±0.09)、(0.39±0.06)、(0.23±0.07)mmol/L,妊娠期高血压疾病各组TG水平均高于正常对照组,且随母亲妊娠期高血压程度的加重呈进行性的升高,组间比较差异有统计学意义(F=2.765,P<0.05).(2)妊娠期高血压疾病组、子痫前期轻度组、子痫前期重度组、正常对照组新生儿脐血HDL-C的浓度分别为(0.61±0.23)、(0.54±0.25)、(0.47±0.15)、(0.65±0.14)mmol/L;ApoA的浓度分别为(0.63±0.24)、(0.59±0.16)、(0.53 ±0.21)、(0.69±0.12)g/L,妊娠期高血压疾病各组新生儿脐血HDL-C、ApoA均低于正常对照组,且随母亲妊娠期高血压程度的加重呈进行性的降低,组间比较差异有统计学意义(F=2.783,P<0.05;F=2.831,JP<0.05).(3)妊娠期高血压疾病组、子痫前期轻度组、子痫前期重度组、正常对照组新生儿脐血TC的浓度分别为(1.41±0.37)、(1.51±0.45)、(1.56±0.56)、(1.36±0.41)mmol/L;LDL-C的浓度分别为(0.79 ±0.26)、(0.80 ±0.18)、(0.82±0.30)、(0.74±0.18)mmol/L,妊娠期高血压疾病各组新生儿脐血TC、LDL-C均高于正常对照组,且随母亲妊娠期高血压程度的加重呈进行性升高,组间比较差异无统计学意义(F=0.695,P>0.05;F=0.483,P>0.05).(4)子痫前期轻度组、子痫前期重度组新生儿脐血LPA分别为(24.50±12.01)g/L与(22.68±9.50)g/L,低于正常对照组(25.70±11.90)g/L,妊娠期高血压组新生儿脐血LPA(33.46±20.10)g/L高于正常对照组,且妊娠期高血压疾病各组新生儿脐血LPA随母亲妊娠期高血压疾病程度的加重呈进行性降低,但组间比较差异无统计学意义(F=1.480,P>0.05).结论 妊娠期高血压疾病时官内的不良环境使胎儿脂代谢发生改变,且随母亲妊娠期高血压程度的加重,这种改变越重,推测妊娠期高血压组母儿以后可能发生冠心病、动脉粥样硬化与脂代谢相关性疾病的危险性较正常对照组有可能增加.
目的 探討妊娠期高血壓疾病(PIH)對新生兒血脂的影響.方法 PIH母兒80例,按第6版婦產科學PIH診斷標準分為3組:妊娠期高血壓疾病組30例、子癇前期輕度組30例、子癇前期重度組20例,另設同期正常對照組40名,採用全自動生化分析儀測定臍血甘油三酯(TG)、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、ApoA及脂蛋白(LPA).結果 (1)妊娠期高血壓疾病組、子癇前期輕度組、子癇前期重度組、正常對照組新生兒臍血TG的濃度分彆為(0.25±0.10)、(0.33±0.09)、(0.39±0.06)、(0.23±0.07)mmol/L,妊娠期高血壓疾病各組TG水平均高于正常對照組,且隨母親妊娠期高血壓程度的加重呈進行性的升高,組間比較差異有統計學意義(F=2.765,P<0.05).(2)妊娠期高血壓疾病組、子癇前期輕度組、子癇前期重度組、正常對照組新生兒臍血HDL-C的濃度分彆為(0.61±0.23)、(0.54±0.25)、(0.47±0.15)、(0.65±0.14)mmol/L;ApoA的濃度分彆為(0.63±0.24)、(0.59±0.16)、(0.53 ±0.21)、(0.69±0.12)g/L,妊娠期高血壓疾病各組新生兒臍血HDL-C、ApoA均低于正常對照組,且隨母親妊娠期高血壓程度的加重呈進行性的降低,組間比較差異有統計學意義(F=2.783,P<0.05;F=2.831,JP<0.05).(3)妊娠期高血壓疾病組、子癇前期輕度組、子癇前期重度組、正常對照組新生兒臍血TC的濃度分彆為(1.41±0.37)、(1.51±0.45)、(1.56±0.56)、(1.36±0.41)mmol/L;LDL-C的濃度分彆為(0.79 ±0.26)、(0.80 ±0.18)、(0.82±0.30)、(0.74±0.18)mmol/L,妊娠期高血壓疾病各組新生兒臍血TC、LDL-C均高于正常對照組,且隨母親妊娠期高血壓程度的加重呈進行性升高,組間比較差異無統計學意義(F=0.695,P>0.05;F=0.483,P>0.05).(4)子癇前期輕度組、子癇前期重度組新生兒臍血LPA分彆為(24.50±12.01)g/L與(22.68±9.50)g/L,低于正常對照組(25.70±11.90)g/L,妊娠期高血壓組新生兒臍血LPA(33.46±20.10)g/L高于正常對照組,且妊娠期高血壓疾病各組新生兒臍血LPA隨母親妊娠期高血壓疾病程度的加重呈進行性降低,但組間比較差異無統計學意義(F=1.480,P>0.05).結論 妊娠期高血壓疾病時官內的不良環境使胎兒脂代謝髮生改變,且隨母親妊娠期高血壓程度的加重,這種改變越重,推測妊娠期高血壓組母兒以後可能髮生冠心病、動脈粥樣硬化與脂代謝相關性疾病的危險性較正常對照組有可能增加.
목적 탐토임신기고혈압질병(PIH)대신생인혈지적영향.방법 PIH모인80례,안제6판부산과학PIH진단표준분위3조:임신기고혈압질병조30례、자간전기경도조30례、자간전기중도조20례,령설동기정상대조조40명,채용전자동생화분석의측정제혈감유삼지(TG)、총담고순(TC)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、ApoA급지단백(LPA).결과 (1)임신기고혈압질병조、자간전기경도조、자간전기중도조、정상대조조신생인제혈TG적농도분별위(0.25±0.10)、(0.33±0.09)、(0.39±0.06)、(0.23±0.07)mmol/L,임신기고혈압질병각조TG수평균고우정상대조조,차수모친임신기고혈압정도적가중정진행성적승고,조간비교차이유통계학의의(F=2.765,P<0.05).(2)임신기고혈압질병조、자간전기경도조、자간전기중도조、정상대조조신생인제혈HDL-C적농도분별위(0.61±0.23)、(0.54±0.25)、(0.47±0.15)、(0.65±0.14)mmol/L;ApoA적농도분별위(0.63±0.24)、(0.59±0.16)、(0.53 ±0.21)、(0.69±0.12)g/L,임신기고혈압질병각조신생인제혈HDL-C、ApoA균저우정상대조조,차수모친임신기고혈압정도적가중정진행성적강저,조간비교차이유통계학의의(F=2.783,P<0.05;F=2.831,JP<0.05).(3)임신기고혈압질병조、자간전기경도조、자간전기중도조、정상대조조신생인제혈TC적농도분별위(1.41±0.37)、(1.51±0.45)、(1.56±0.56)、(1.36±0.41)mmol/L;LDL-C적농도분별위(0.79 ±0.26)、(0.80 ±0.18)、(0.82±0.30)、(0.74±0.18)mmol/L,임신기고혈압질병각조신생인제혈TC、LDL-C균고우정상대조조,차수모친임신기고혈압정도적가중정진행성승고,조간비교차이무통계학의의(F=0.695,P>0.05;F=0.483,P>0.05).(4)자간전기경도조、자간전기중도조신생인제혈LPA분별위(24.50±12.01)g/L여(22.68±9.50)g/L,저우정상대조조(25.70±11.90)g/L,임신기고혈압조신생인제혈LPA(33.46±20.10)g/L고우정상대조조,차임신기고혈압질병각조신생인제혈LPA수모친임신기고혈압질병정도적가중정진행성강저,단조간비교차이무통계학의의(F=1.480,P>0.05).결론 임신기고혈압질병시관내적불량배경사태인지대사발생개변,차수모친임신기고혈압정도적가중,저충개변월중,추측임신기고혈압조모인이후가능발생관심병、동맥죽양경화여지대사상관성질병적위험성교정상대조조유가능증가.
Objective To investigate the effect of pregnancy-induced hypertension (PIH) syndrome on the blood lipid level of neonate. Methods Eighty neonates, whose mother had PIH, were enrolled and divided into three groups according to the 6th version of diagnostic standard from published Obstetrics and Gynecology:gestational hypertension group (PIH group 1 ,n = 30) ,mild pre-eclampsia group (PIH group 2,n =30),serious pre-eclampsia group (PIH group 3,n =20) ,and 40 infants with healthy mother were enrolled as normal control group. The blood lipid was measured by automatic biochemical analyzer. Results (1) The TG levels of the cord blood were (0.28±0. 10)mmol/L in PIH group 1,(0.33 ±0.09)mmol/L in PIH group 2,(0.39 ±0.06) mmol/L in PIH group 3,and (0. 23 ±0. 07)mmol/L in normal control respectively. TG levels were significantly higher in PIH groups compared to normal control,and the TG concentration increased gradually with the mothers' gestational hypertension (F = 2. 765, Ps <0. 05). (2)The HDL-C levels of the cord blood were (0. 61 ±0. 23) mmol/L in PIH group 1, (0. 54 ± 0. 25) mmol/L in PIH group 2, (0.47 ± 0. 15) mmol/L in PIH group 3, (0. 65 ±0. 14) mmol/L in the normal contral respectively;and the ApoA levels of the cord blood were (0. 63 ±0.24)g/L in PIH group 1 ,(0. 59 ±0. 16)g/L in PIH group 2, (0.53 ±0.21)g/L in PIH group 3,(0.69 ±0. 12)g/L in the normal contral respectively. Both index were significantly higher in PIH groups compared to normal control, and the concentrations decreased gradually with the mothers' gestational hypertension (F=2.783,P<0.05;F=2.831,P<0.05). (3)The TC levels of the cord blood were (1.41 ± 0. 37) mmol/L in PIH group 1, (1. 51 ±0.45) mmol/L in PIH group 2, (1. 56 ±0. 56) mmol/L in PIH group3, (1. 36 ±0.41) mmol/L in the normal contral respectively;and the LDL-C levels of the cord blood were (0. 79 ±0. 26)mmol/L in PIH group 1,(0. 80 ±0. 18)mmol/L in PIH group 2,(0. 82 ±0. 30)mmol/L in PIH group 3,(0.74 ±0. 18) mmol/L in the normal contral respectively. The data showed that the cord blood TC and LDL-C levels of PIH were higher than normal control and increased gradually with the mothers'gestational hypertension, but they didn' treach the significant level (F = 0. 695,P>0. 05;F = 0. 483,P>0. 05). (4)The LPA levels of the cord blood were (24. 50 ± 12. 01) g/L in PIH group 2, (22. 68 ± 9. 50) g/L PIH group 3,which were lower than normal control (25.70 ±11.90) g/L, and the LPA levels of the cord blood were higher in PIH group 1(33.46 ± 20. 10)g/L,while the differences didn't reach significant level compared among four groups (F = 1.480,P> 0.05). Conclusion The unhealthy intrauterus condition of PIH lead abmoral fat metabolism in fetus, and itmight get worse along with the severity of the mother's gestational hypertension. We presumed that the neonates of PIH mothers would be more prone to have coronary heart disease,atherosclerosis and abnormal fat metabolism related disease compared with newboms from normal control group.
