CAJ | 학술논문

目的观察黄芪对中晚期胸部肿瘤放射治疗的肺保护作用及对肿瘤坏死因子-α(TNF-α)和内皮素(ET)表达水平的影响.方法将中晚期胸部肿瘤放射治疗患者79例随机分为治疗组(41例)和对照组(38例).治疗组在放射治疗开始起服用黄芪10 ml,2次/d,连续6个月,对照组为单纯放射治疗.放射治疗前后测定血浆TNF-α和ET,放射治疗开始15 d起观察临床症状、影像学改变和肺弥散功能.结果在放射治疗后测定血浆TNF-α和ET,治疗组分别为(2.48±0.75)as/ml和(69.32±23.03)pg/ml;对照组分别为(5.12±1.01)ng/ml和(97.87±37.83)pg/ml;对照组较治疗组明显升高(x2=7.49、6.57,P<0.001).放射治疗开始后5个月和10个月治疗组CO弥散量下降情况较对照组差异有统计学意义(x2=3.98、3.78,P<0.05).结论黄芪能抑制放射治疗后血浆TNF-α和ET的过度表达,降低放射治疗后弥散功能的恶化,用于放射性肺损伤的干预.
목적 관찰황기대중만기흉부종류방사치료적폐보호작용급대종류배사인자-α(TNF-α)화내피소(ET)표체수평적영향.방법 장중만기흉부종류방사치료환자79례수궤분위치료조(41례)화대조조(38례).치료조재방사치료개시기복용황기10 ml,2차/d,련속6개월,대조조위단순방사치료.방사치료전후측정혈장TNF-α화ET,방사치료개시15 d기관찰림상증상、영상학개변화폐미산공능.결과 재방사치료후측정혈장TNF-α화ET,치료조분별위(2.48±0.75)as/ml화(69.32±23.03)pg/ml;대조조분별위(5.12±1.01)ng/ml화(97.87±37.83)pg/ml;대조조교치료조명현승고(x2=7.49、6.57,P<0.001).방사치료개시후5개월화10개월치료조CO미산량하강정황교대조조차이유통계학의의(x2=3.98、3.78,P<0.05).결론 황기능억제방사치료후혈장TNF-α화ET적과도표체,강저방사치료후미산공능적악화,용우방사성폐손상적간예.
Objective To observe the lung protection of Astragalus membranaceus against radiotherapy to intermediate-stage and terminal thoracic neoplasm, and its influence on TNF-α and ET expression.Methods The patients with intermediate-stage and terminal thoracic neoplasm under radiotherapy were divided into a treatment group and a control group.Patients in the treatment group took 10 ml of Asragalus membranaceus twice a day.for consecutive 6 months from the beginning of radio therapy.TNF-α and ET in the plasma were measured before and after the radiotherapy.The clinical symptom,iconographic changes and lung diffusion were observed from the 15th day of radiotherapy.Results The TNF-α and ET in plasma afterthe radiotherapy were(2.48±0.75)as/ml and(69.32±23.03)pg/ml for the treatment group,and(5.12±1.01)ns/ml and(97.87±37.83)pg/ml for the control group with the statistial difference(x2=7.49,6.57,P<0.001).The decrease of CO diffusion 5 and 10 months after the radiotherapy in the treatment group was statistically different compared with that in the control group(x2=3.98,3.78,P<0.05).There was a statistical difference of the incidence of acute radiation pneumonitis and pulmonary fibrosis between these two groups(P<0.05).Conclusions Astragalus membranaceus could inhibit the excess expression of TNF-α and ET in plasma and reduce the deterioration of diffusion after radiotherapy,so that it can be used for intervention of lung injuries from radiotherapy.