中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2010年
6期
789-791
,共3页
戴奇山%叶永康%毕学成%何慧婵%韩兆冬%梁宇翔%陈清标%王月生%钟惟德
戴奇山%葉永康%畢學成%何慧嬋%韓兆鼕%樑宇翔%陳清標%王月生%鐘惟德
대기산%협영강%필학성%하혜선%한조동%량우상%진청표%왕월생%종유덕
CK20%Ki-67%膀胱癌/肿瘤学%诊断%基因表达
CK20%Ki-67%膀胱癌/腫瘤學%診斷%基因錶達
CK20%Ki-67%방광암/종류학%진단%기인표체
CK20%Ki-67%Bladder-cancer/ oncology%Diagnosis%Gene expression
目的 探讨角蛋白20(CK20)和Ki-67在膀胱癌中的表达与膀胱癌的侵袭、转移及预后的关系.方法 用免疫组织化学SP法检测154例膀胱癌组织中CK20和Ki-67的表达.结果 CK20在103例肿瘤组织中有表达,阳性率为66.9%.CK20的表达和膀胱癌的T分期及远处转移呈正相关(P<0.05).Ki-67在126例肿瘤组织中有阳性表达,阳性率为81.8%.Ki-67在膀胱癌组织的表达与肿瘤病理分级、T分期、远处转移呈正相关(P<0.05).Spearman等级相关分析表明两者明显相关(P<0.05).结论 CK20及Ki-67可能参与了膀胱癌的侵袭与转移,CK20与Ki-67可作为预后判断因子,结合病理分级和临床分期分析能提高对膀胱癌患者预后判断的准确性.
目的 探討角蛋白20(CK20)和Ki-67在膀胱癌中的錶達與膀胱癌的侵襲、轉移及預後的關繫.方法 用免疫組織化學SP法檢測154例膀胱癌組織中CK20和Ki-67的錶達.結果 CK20在103例腫瘤組織中有錶達,暘性率為66.9%.CK20的錶達和膀胱癌的T分期及遠處轉移呈正相關(P<0.05).Ki-67在126例腫瘤組織中有暘性錶達,暘性率為81.8%.Ki-67在膀胱癌組織的錶達與腫瘤病理分級、T分期、遠處轉移呈正相關(P<0.05).Spearman等級相關分析錶明兩者明顯相關(P<0.05).結論 CK20及Ki-67可能參與瞭膀胱癌的侵襲與轉移,CK20與Ki-67可作為預後判斷因子,結閤病理分級和臨床分期分析能提高對膀胱癌患者預後判斷的準確性.
목적 탐토각단백20(CK20)화Ki-67재방광암중적표체여방광암적침습、전이급예후적관계.방법 용면역조직화학SP법검측154례방광암조직중CK20화Ki-67적표체.결과 CK20재103례종류조직중유표체,양성솔위66.9%.CK20적표체화방광암적T분기급원처전이정정상관(P<0.05).Ki-67재126례종류조직중유양성표체,양성솔위81.8%.Ki-67재방광암조직적표체여종류병리분급、T분기、원처전이정정상관(P<0.05).Spearman등급상관분석표명량자명현상관(P<0.05).결론 CK20급Ki-67가능삼여료방광암적침습여전이,CK20여Ki-67가작위예후판단인자,결합병리분급화림상분기분석능제고대방광암환자예후판단적준학성.
Objective To investigate the correlation of CK20 and Ki-67 expression in tumor to metastasis, invasion, and prognosis of bladder cancer. Methods The expression of CK20 and Ki-67 in 154 specimens of bladder cancer was detected by SP immunohistochemistry. Results Positive rate of CK20 was 66. 9% in bladder cancer tissues. CK20 staining in cancer tissue was positively related with T stage and distant metastasis (P<0.05). Positive rate of Ki-67 was 81.8% in bladder cancer tissues. Ki-67 staining in cancer tissue was positively related with pathologic grade and T stage and distant metastasis (P < 0.05). Spearman' s rank correlation had showed both correlations (P < 0. 05). Conclusion CK20 and Ki-67 maybe participate in invasion and metastasis of bladder cancer. CK20 and Ki-67 may be an prognostic factor and when used in combination with pathologic grading and clinical staging, may increase accuracy of predicting prognosis of patients with bladder cancer.
