中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2011年
5期
463-467
,共5页
周京敏%崔晓通%金雪娟%周俊%葛均波
週京敏%崔曉通%金雪娟%週俊%葛均波
주경민%최효통%금설연%주준%갈균파
心血管疾病%尿微量白蛋白/尿肌酐比值%老年人
心血管疾病%尿微量白蛋白/尿肌酐比值%老年人
심혈관질병%뇨미량백단백/뇨기항비치%노년인
Cardiovascular diseases%Urinary microalbumin/creatinine ratio%Aged
目的 研究社区65岁及以上老年人群尿微量白蛋白/尿肌酐比值(UACR)现况及其与心血管病危险因素的关系.方法 对"十一五"国家科技支撑计划"慢性心力衰竭早期预警和失代偿期综合防治的研究"的社区队列研究中一个农村社区所有65岁及以卜老年人进行包括心血管病危险因素在内的基线情况调查,并留取清晨点时间尿样检测尿微量白蛋白、尿肌酐和UACR等,分析UACR在健康人群以及具有心血管病危险因素人群中的分布情况.结果 (1)完成调查的65岁及以上老年人共1718名,其中男性721名,女性997名,年龄(73.3±5.5)岁.(2)调查的老年人群中,有至少1种心血管病危险因素者占78.00%,患病率排在前3位的心血管病危险凶素依次是血脂异常、高血压和糖尿病,其患病率分别为61.06%、44.59%和13.80%.(3)健康人群UACR中位数为13.81(6.03～26.51)μg/mg,其中男性为5.49(2.92～9.76)μg/mg,女性为17.12(7.28～33.28)μg/mg,女性显著高于男性(P<0.01).(4)具有高血压、糖尿病和血脂异常人群的UACR分别为16.27(6.65～42.00)μg/mg、26.27(10.92～76.65)μg/mg和16.39(6.98～41.03)μg/mg,均高于健康人群(P<0.05或P<0.01).(5)具有0、1、2,3和4个心血管病危险因素人群的UACR中位数分别为13.81(6.03～26.51)μg/mg、15.76(6.79～36.44)μg/mg、13.82(5.68～34.43)μg/mg、16.47(6.07～50.56)μg/mg和18.63(11.26～83.09)μg/mg,具有4个危险因素人群的UACR水平显著高于无危险因素人群(P<0.05).结论 65岁及以上社区老年人群患病率排在前3位的心血管病危险因素依次是血脂异常、高血压和糖尿病,三者均与UACR增高有关.
目的 研究社區65歲及以上老年人群尿微量白蛋白/尿肌酐比值(UACR)現況及其與心血管病危險因素的關繫.方法 對"十一五"國傢科技支撐計劃"慢性心力衰竭早期預警和失代償期綜閤防治的研究"的社區隊列研究中一箇農村社區所有65歲及以蔔老年人進行包括心血管病危險因素在內的基線情況調查,併留取清晨點時間尿樣檢測尿微量白蛋白、尿肌酐和UACR等,分析UACR在健康人群以及具有心血管病危險因素人群中的分佈情況.結果 (1)完成調查的65歲及以上老年人共1718名,其中男性721名,女性997名,年齡(73.3±5.5)歲.(2)調查的老年人群中,有至少1種心血管病危險因素者佔78.00%,患病率排在前3位的心血管病危險兇素依次是血脂異常、高血壓和糖尿病,其患病率分彆為61.06%、44.59%和13.80%.(3)健康人群UACR中位數為13.81(6.03～26.51)μg/mg,其中男性為5.49(2.92～9.76)μg/mg,女性為17.12(7.28～33.28)μg/mg,女性顯著高于男性(P<0.01).(4)具有高血壓、糖尿病和血脂異常人群的UACR分彆為16.27(6.65～42.00)μg/mg、26.27(10.92～76.65)μg/mg和16.39(6.98～41.03)μg/mg,均高于健康人群(P<0.05或P<0.01).(5)具有0、1、2,3和4箇心血管病危險因素人群的UACR中位數分彆為13.81(6.03～26.51)μg/mg、15.76(6.79～36.44)μg/mg、13.82(5.68～34.43)μg/mg、16.47(6.07～50.56)μg/mg和18.63(11.26～83.09)μg/mg,具有4箇危險因素人群的UACR水平顯著高于無危險因素人群(P<0.05).結論 65歲及以上社區老年人群患病率排在前3位的心血管病危險因素依次是血脂異常、高血壓和糖尿病,三者均與UACR增高有關.
목적 연구사구65세급이상노년인군뇨미량백단백/뇨기항비치(UACR)현황급기여심혈관병위험인소적관계.방법 대"십일오"국가과기지탱계화"만성심력쇠갈조기예경화실대상기종합방치적연구"적사구대렬연구중일개농촌사구소유65세급이복노년인진행포괄심혈관병위험인소재내적기선정황조사,병류취청신점시간뇨양검측뇨미량백단백、뇨기항화UACR등,분석UACR재건강인군이급구유심혈관병위험인소인군중적분포정황.결과 (1)완성조사적65세급이상노년인공1718명,기중남성721명,녀성997명,년령(73.3±5.5)세.(2)조사적노년인군중,유지소1충심혈관병위험인소자점78.00%,환병솔배재전3위적심혈관병위험흉소의차시혈지이상、고혈압화당뇨병,기환병솔분별위61.06%、44.59%화13.80%.(3)건강인군UACR중위수위13.81(6.03～26.51)μg/mg,기중남성위5.49(2.92～9.76)μg/mg,녀성위17.12(7.28～33.28)μg/mg,녀성현저고우남성(P<0.01).(4)구유고혈압、당뇨병화혈지이상인군적UACR분별위16.27(6.65～42.00)μg/mg、26.27(10.92～76.65)μg/mg화16.39(6.98～41.03)μg/mg,균고우건강인군(P<0.05혹P<0.01).(5)구유0、1、2,3화4개심혈관병위험인소인군적UACR중위수분별위13.81(6.03～26.51)μg/mg、15.76(6.79～36.44)μg/mg、13.82(5.68～34.43)μg/mg、16.47(6.07～50.56)μg/mg화18.63(11.26～83.09)μg/mg,구유4개위험인소인군적UACR수평현저고우무위험인소인군(P<0.05).결론 65세급이상사구노년인군환병솔배재전3위적심혈관병위험인소의차시혈지이상、고혈압화당뇨병,삼자균여UACR증고유관.
objective To determine the value of the urinary microalbumin/creatinine ratio (UACR)and the relationship between UACR and traditional cardiovascular risk factors among elderly community subjects.Methods A representative population in Shanghai rural district aged more than 65years who participated in the heart health survey of the key projects in the national science and technology pillar program in the eleventh five-year plan period of China were sampled via a clustered complex sampling method.A midstream collection from the first morning void collected was used to measure the urinary microalbumin,the urinary creatinine and the UACR.Baseline information including traditional cardiovascular risk factors were obtained by standard questionaire to analyze the distribution status of UACR in the population with or without the risk factors.Results (1)There were 1718 subjects(721 males)of(73.3±5.5)years included in this study.(2)The prevalence of with at least one cardiovascular risk factor was 78.00%in this cohort,the top there risk factors were dyslipidemia(61.06%),hypertension(44.59%)and diabetes(13.80%).(3)The median(the lower quartile-the upper quartile)of the UACR of the population without cardiovascular diseases and risk factors was 13.81(6.03-26.51)μg/mg.The level of UACR was significantly higher in females than that in males[17.12(7.28-33.28)μg/mg vs.5.49(2.92-9.76)μg/mg,P<0.01].(4) The level of UACR in population with hypertension,diabetes or dyslipidemia was 16.27(6.65-42.00)μg/mg,26.27(10.92-76.65)μg/mg and 16.39(6.98-41.03)μg/mg respectively,all exceeding that of the healthy group(P<0.05 or P<0.01).(5)The levels of UACR increased in proportion to the increase of cardiovascular risk factor numbers, the UACR of the population with 0, 1,2, 3 and 4 cardiovascular risk factors were 13. 81 (6. 03 - 26. 51 ) μg/mg, 15.76(6.79-36.44)μg/mg, 13.82 (5.68-34.43) μg/mg, 16.47 (6.07-50.56) μg/mg and 18.63( 11.26 - 83.09 ) μg/mg, respectively. The population with 4 cluster of cardiovascular risk factors posed the higher level of UACR than that of population with 0 cardiovascular risk factors ( P < 0. 05 ). Conclusions The three most common risk factors of cardiovascular diseases among the elderly community subjects aged more than 65 years are dyslipidemia, hypertension and diabetes, all of which are related to the elevation of UACR.
