中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2011年
6期
564-567
,共4页
视网膜病,早产儿%疾病遗传易感性%多态现象,遗传%突变
視網膜病,早產兒%疾病遺傳易感性%多態現象,遺傳%突變
시망막병,조산인%질병유전역감성%다태현상,유전%돌변
Retinopathy of prematurity%Genetic predisposition to disease%Polymorphism,genetic%Mutation
早产儿视网膜病变(ROP)是发生在孕周小、出生体重轻的早产儿中最严重的疾病.尽管ROP的诊断和治疗水平不断上升,但在发达及发展中国家,ROP仍然是儿童致盲的主要原因.迄今,虽然对ROP的发病机制已取得一定共识,但仍有一些未知问题.以往的研究结果已经证实孕周、出生体重、吸氧时间等因素与ROP的发生、发展有密切关系,但近年来,不断有新的研究结果揭示ROP有一定的遗传易感性,包括性别、种族、基因的多态性及基因突变等.这些遗传易感性的发现对今后严重ROP患儿的筛查和治疗具有重要意义,因此有必要予以综述.(中华眼科杂志,2011,47:564-567)
早產兒視網膜病變(ROP)是髮生在孕週小、齣生體重輕的早產兒中最嚴重的疾病.儘管ROP的診斷和治療水平不斷上升,但在髮達及髮展中國傢,ROP仍然是兒童緻盲的主要原因.迄今,雖然對ROP的髮病機製已取得一定共識,但仍有一些未知問題.以往的研究結果已經證實孕週、齣生體重、吸氧時間等因素與ROP的髮生、髮展有密切關繫,但近年來,不斷有新的研究結果揭示ROP有一定的遺傳易感性,包括性彆、種族、基因的多態性及基因突變等.這些遺傳易感性的髮現對今後嚴重ROP患兒的篩查和治療具有重要意義,因此有必要予以綜述.(中華眼科雜誌,2011,47:564-567)
조산인시망막병변(ROP)시발생재잉주소、출생체중경적조산인중최엄중적질병.진관ROP적진단화치료수평불단상승,단재발체급발전중국가,ROP잉연시인동치맹적주요원인.흘금,수연대ROP적발병궤제이취득일정공식,단잉유일사미지문제.이왕적연구결과이경증실잉주、출생체중、흡양시간등인소여ROP적발생、발전유밀절관계,단근년래,불단유신적연구결과게시ROP유일정적유전역감성,포괄성별、충족、기인적다태성급기인돌변등.저사유전역감성적발현대금후엄중ROP환인적사사화치료구유중요의의,인차유필요여이종술.(중화안과잡지,2011,47:564-567)
Retinopathy of prematurity (ROP) is a proliferative disease that affects prematurely born babies. Despite the progress in management and treatment obtained previously, ROP remains a major cause of childhood blindness in both developed and developing countries. The etiology and pathogenesis of ROP is still unclear despite the fact that some progresses have been obtained. Some factors, such as low birth-weight and short gestational age have been consistently shown to be associated with ROP. Recently, numerous studies indicated that ROP shows genetic susceptibility, which includes sex, ethnicity, gene polymorphisms and gene mutations. Genetic susceptibility will play an important role in the screening and treatment of advanced ROP in the future.
