中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2010年
1期
29-33
,共5页
张菊红%李南方%严治涛%郭艳英%周玲%王红梅%杨进%罗文利%常建航
張菊紅%李南方%嚴治濤%郭豔英%週玲%王紅梅%楊進%囉文利%常建航
장국홍%리남방%엄치도%곽염영%주령%왕홍매%양진%라문리%상건항
RGS2基因%1891-1892del%TC%原发性高血压%血清尿酸
RGS2基因%1891-1892del%TC%原髮性高血壓%血清尿痠
RGS2기인%1891-1892del%TC%원발성고혈압%혈청뇨산
RGS2 gene%1891-1892del TC%primary hypertension%serum uric acid
目的 研究在新疆哈萨克族人群中G蛋白信号转导调节蛋白-2基因(regulator of G-protein signaling 2,RGS2)1891-1892del TC位点多态性与原发性高血压遗传易感性的关系.方法 采用病例(444例)-对照(489例)方法 进行关联分析,用TaqMan荧光实时定量PCR检测1891-1892del TC位点的基因型.结果 1891-1892del TC在该人群男性中(OR=1.698,P=0.03)以及总体人群中(OR=1.32,P=0.044)与高血压病显著相关;ID+DD基因型组的平均收缩压水平明显高于Ⅱ基因型组(P=0.04);DD和ID基因型组的血清尿酸水平均高于Ⅱ基因型组(P<0.01).结论 研究结果表明RGS2基因的D等位基因与新疆哈萨克族原发性高血压的遗传易感性相关,同时与血清尿酸水平升高相关.
目的 研究在新疆哈薩剋族人群中G蛋白信號轉導調節蛋白-2基因(regulator of G-protein signaling 2,RGS2)1891-1892del TC位點多態性與原髮性高血壓遺傳易感性的關繫.方法 採用病例(444例)-對照(489例)方法 進行關聯分析,用TaqMan熒光實時定量PCR檢測1891-1892del TC位點的基因型.結果 1891-1892del TC在該人群男性中(OR=1.698,P=0.03)以及總體人群中(OR=1.32,P=0.044)與高血壓病顯著相關;ID+DD基因型組的平均收縮壓水平明顯高于Ⅱ基因型組(P=0.04);DD和ID基因型組的血清尿痠水平均高于Ⅱ基因型組(P<0.01).結論 研究結果錶明RGS2基因的D等位基因與新疆哈薩剋族原髮性高血壓的遺傳易感性相關,同時與血清尿痠水平升高相關.
목적 연구재신강합살극족인군중G단백신호전도조절단백-2기인(regulator of G-protein signaling 2,RGS2)1891-1892del TC위점다태성여원발성고혈압유전역감성적관계.방법 채용병례(444례)-대조(489례)방법 진행관련분석,용TaqMan형광실시정량PCR검측1891-1892del TC위점적기인형.결과 1891-1892del TC재해인군남성중(OR=1.698,P=0.03)이급총체인군중(OR=1.32,P=0.044)여고혈압병현저상관;ID+DD기인형조적평균수축압수평명현고우Ⅱ기인형조(P=0.04);DD화ID기인형조적혈청뇨산수평균고우Ⅱ기인형조(P<0.01).결론 연구결과표명RGS2기인적D등위기인여신강합살극족원발성고혈압적유전역감성상관,동시여혈청뇨산수평승고상관.
Objective To investigate the association of the 1891-1892del TC polymorphism of regulator of G-protein signalling 2 (RGS2) gene with hypertension in Xinjiang Kazakh population. Methods The case-control study was performed in 444 cases and 489 controls. The genotypes of the individuals in the 1891-1892del TC locus were identified by TaqMan method. Results A significant association was observed between the1891-1892TC insertion/deletion polymorphism with hypertension in men (OR = 1.698, P=0.03) and in the total population (OR= 1.32, P=0. 044). The mean systolic blood pressure and serum uric acid levels of the ID+DD carriers were significantly higher than that of the Ⅱ carriers (adjusted, P = 0.04and P<0.01). Conclusion The results suggest that the D allele of the 1891-1892TC insertion/deletion locus of the RGS2 gene might be an independent risk factor for hypertension in Xinjiang Kazakhs; and the polymorphism may have some influence on serum uric acid level in this population.
