CAJ | 학술논문

目的研究交联聚乙烯基吡咯烷酮水凝胶与硅橡胶共混,形成可自行膨胀的复合材料的可行性.方法将不同比例的复合材料植入24只新西兰白兔背部及鼻背皮下,与硅胶假体比较观察膨胀状况,和机体的反应及复合材料自行软组织扩张的效果.结果通过200 d的连续观察,植入兔子皮下的复合材料按照设计膨胀量膨胀,与硅胶材料对比有明显的膨胀性,在一定的时间内最终达到平衡静止;通过组织切片检查,复合材料的周围组织的炎性反应和排斥反应与硅胶相同,上皮基底细胞的有丝分裂活跃.结论可自行膨胀的交联聚乙烯基吡咯烷酮硅橡胶复合材料具有优于硅胶的自行扩张膨胀性能,从而达到扩张软组织的目的 .
목적 연구교련취을희기필각완동수응효여규상효공혼,형성가자행팽창적복합재료적가행성.방법 장불동비례적복합재료식입24지신서란백토배부급비배피하,여규효가체비교관찰팽창상황,화궤체적반응급복합재료자행연조직확장적효과.결과 통과200 d적련속관찰,식입토자피하적복합재료안조설계팽창량팽창,여규효재료대비유명현적팽창성,재일정적시간내최종체도평형정지;통과조직절편검사,복합재료적주위조직적염성반응화배척반응여규효상동,상피기저세포적유사분렬활약.결론 가자행팽창적교련취을희기필각완동규상효복합재료구유우우규효적자행확장팽창성능,종이체도확장연조직적목적 .
Objective To study the feasibility of Polyvinylpolypyrrolidone(PVPP)/silicone composite automatic expanded material as implants. Methods The PVPP hydrngel was mixed with silicone through the thiolocation at the high temperature. Implants with different ratio of PVPP to silicone were placed under the back and nose skin in 24 New Zealand rabbits. The surrounding tissue reaction, material and skin expansion were observed and compared with those with pure silicone implants. Results The study lasted for 200 days. Compared with pure silicone implants, the composite material could expand antomatically and stop expanding at about 2 weeks after implantation. Histological study showed similar infectional and foreign body reaction around the composite material and the pure silicone. Conclusions Compared with pure silicone, the PVPP/silicone composite implant has the advantage of automatic expansion, so as to expand the soft tissue.