中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2009年
12期
5-6
,共2页
范立昌%薛玲%王静%高鲁霞
範立昌%薛玲%王靜%高魯霞
범립창%설령%왕정%고로하
结肠清颗粒%溃疡性结肠炎%IL-1%ICAM-1
結腸清顆粒%潰瘍性結腸炎%IL-1%ICAM-1
결장청과립%궤양성결장염%IL-1%ICAM-1
Jiangchangqing%Ulcerative colitis%IL-1%ICAM-1
目的:探讨结肠清颗粒对溃疡性结肠炎模型大鼠血清白细胞介素1(IL-1)、细胞黏附因子(ICAM-1)的影响.方法:用家兔结肠加弗氏佐剂复制大鼠溃疡性结肠炎模型,检测模型大鼠血清IL-1、ICAM-1含量.结果:结肠清颗粒能显著增加溃疡性结肠炎模型大鼠血清IL-1及ICAM-1的含量:显著降低溃疡性结肠炎模型大鼠结肠的病理改变,对模型大鼠结肠有显著的修复作用.结论:结肠清颗粒治疗溃疡性结肠炎的作用可能与其升高血清IL-1及I-CAM-1的含量,从而改善免疫功能,减轻炎症损伤有关.
目的:探討結腸清顆粒對潰瘍性結腸炎模型大鼠血清白細胞介素1(IL-1)、細胞黏附因子(ICAM-1)的影響.方法:用傢兔結腸加弗氏佐劑複製大鼠潰瘍性結腸炎模型,檢測模型大鼠血清IL-1、ICAM-1含量.結果:結腸清顆粒能顯著增加潰瘍性結腸炎模型大鼠血清IL-1及ICAM-1的含量:顯著降低潰瘍性結腸炎模型大鼠結腸的病理改變,對模型大鼠結腸有顯著的脩複作用.結論:結腸清顆粒治療潰瘍性結腸炎的作用可能與其升高血清IL-1及I-CAM-1的含量,從而改善免疫功能,減輕炎癥損傷有關.
목적:탐토결장청과립대궤양성결장염모형대서혈청백세포개소1(IL-1)、세포점부인자(ICAM-1)적영향.방법:용가토결장가불씨좌제복제대서궤양성결장염모형,검측모형대서혈청IL-1、ICAM-1함량.결과:결장청과립능현저증가궤양성결장염모형대서혈청IL-1급ICAM-1적함량:현저강저궤양성결장염모형대서결장적병리개변,대모형대서결장유현저적수복작용.결론:결장청과립치료궤양성결장염적작용가능여기승고혈청IL-1급I-CAM-1적함량,종이개선면역공능,감경염증손상유관.
Objective: To study the effects of Jiechangqing granule on the Ulcerative Colitis (UC) rats. Methods: To make the Ulcerative Colitis model rats by rabbit colon and Feud's adjuvant,and detected contents of IL-1 and ICAM-1 in the serum of the rats. Results: To compare with the model groups,the high-and mederate-dosage groups of Jiechangqing could up-regulated the contents of IL-1 and ICAM-1 and relieve the pathology changes significantly. Conclusion: Jiechangqing granule can up-regulated the levels of IL-1 and ICAM-1 contents in the serum of the rats ,which is the foundation to cure UC.
