CAJ | 학술논문

背景:近年来聚乳酸、羟基磷灰石类复合材料支架具有良好的生物降解性和生物相容性而被广泛的研究,但是这类复合材料在增强材料界面的结合、调节材料的降解速率、改善材料的强度等方面仍不能满足理想的组织工程支架材料的要求.目的:探讨电纺丝法制备纳米纤维的结构形态及表面亲水性.方法:分别将聚乳酸、聚3羟基丁酸酯共聚4羟基丁酸酯和聚碳酸亚丙酯通过静电纺丝法制备纳米纤维膜,扫描电镜对纤维膜的结构形态进行分析,并观察在人体环境相近的磷酸盐缓冲溶液(37℃,pH 7.4)中浸泡不同时间的表面亲水性.结果与结论:通过静电纺丝技术可以将聚乳酸、聚3羟基丁酸酯共聚4羟基丁酸酯和聚碳酸亚丙酯3种材料制各成微纳米纤维结构,控制制备参数可以获得不同直径的纤维,样品随着在培养液中的浸泡时间延长,总体显示出接触角比初始降低,亲水性增强.
배경:근년래취유산、간기린회석류복합재료지가구유량호적생물강해성화생물상용성이피엄범적연구,단시저류복합재료재증강재료계면적결합、조절재료적강해속솔、개선재료적강도등방면잉불능만족이상적조직공정지가재료적요구.목적:탐토전방사법제비납미섬유적결구형태급표면친수성.방법:분별장취유산、취3간기정산지공취4간기정산지화취탄산아병지통과정전방사법제비납미섬유막,소묘전경대섬유막적결구형태진행분석,병관찰재인체배경상근적린산염완충용액(37℃,pH 7.4)중침포불동시간적표면친수성.결과여결론:통과정전방사기술가이장취유산、취3간기정산지공취4간기정산지화취탄산아병지3충재료제각성미납미섬유결구,공제제비삼수가이획득불동직경적섬유,양품수착재배양액중적침포시간연장,총체현시출접촉각비초시강저,친수성증강.
BACKGROUND: Recently, poly (lactic acid)/hydroxyapatite composite scaffolds have been widely used due to good biodegradation and biocompatibility. But poly (lactic acid)/hydroxyapatite composite material can not satisfy the requirements of ideal tissue-engineered scaffold materials owing to drawbacks in some aspects including enhancing material surface binding,adjusting material degradation velocity, and improving material intensity.OBJECTIVE: To investigate the structural morphology and surface hydrophilicity of nanometer fiber membrane prepared by electrospinning.METHODS: Poly(lactic acid), poly (3-hydroxybutyrate-co-4-hydroxybutyrate), and poly(propylene carbonate) nanometer fiber membranes were respectively prepared by electrospinning. The structural morphology of these three nanometer fiber membranes,as well as the surface hydrophilicity after soaking in phosphate buffered saline (37 ℃, pH 7.4) similar to human body environment for different time periods, was observed through the use of scanning electron microscope.RESULTS AND CONCLUSION: Poly(lactic acid), poly(3-hydroxybutyrate-co-4-hydroxybutyrate), and polypropylene carbonate) could be prepared into micro- and nano-sized fiber structure by electrospinning. Different fiber diameters of nanometer fiber membranes could be produced by controlling preparation parameters. With the prolonged soaking time in culture medium, the contact angle of three fiber members was reduced greatly and surface hydrophilicity was gradually enhanced.