国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2011年
23期
2870-2872
,共3页
血液透析%血液灌流%尿毒症%皮肤瘙痒
血液透析%血液灌流%尿毒癥%皮膚瘙癢
혈액투석%혈액관류%뇨독증%피부소양
Hemodialysis%Hemoperfusion%Uremia%Skin-itch
目的 探讨血液透析联合血液灌流治疗尿毒症维持性血液透析患者皮肤瘙痒的疗效.方法 选择我院尿毒症并皮肤瘙痒的维持性血液透析患者55例,随机分为血液透析组和血液透析加血液灌流组.血液透析组25例,接受常规透析治疗,每周2～3次.血液透析加血液灌流组30例,在血液透析组治疗的基础上,联合血液灌流,每2周1次.两组共治疗3个月,治疗前、后观察患者的皮肤瘙痒改善情况,检测血液中甲状旁腺激素、β2微球蛋白、磷离子、钙离子的变化.结果 血液透析加血液灌流组患者血中的甲状旁腺激素[( 314.5±182.4 )ng/L vs.( 479.2±207.1) ng/L]、β2微球蛋白[(16.1±7.3) mg/L vs.(24.2±11.2) mg/L]、磷离子[(2.03±0.91) mmol/L vs.( 2.81±1.42) mmol/L)]明显低于血液透析组(P＜0.05),也较治疗前明显下降(P＜ 0.05),皮肤瘙痒明显改善(24/30),且无不良反应.血液透析组皮肤瘙痒无l例改善,治疗前、后甲状旁腺激素、β2微球蛋白、磷离子无明显变化(P＞ 0.05).两组患者血中钙离子无明显变化(P＞ 0.05).结论 血液透析联合血液灌流是尿毒症维持性血液透析患者皮肤瘙痒的有效治疗方法.
目的 探討血液透析聯閤血液灌流治療尿毒癥維持性血液透析患者皮膚瘙癢的療效.方法 選擇我院尿毒癥併皮膚瘙癢的維持性血液透析患者55例,隨機分為血液透析組和血液透析加血液灌流組.血液透析組25例,接受常規透析治療,每週2～3次.血液透析加血液灌流組30例,在血液透析組治療的基礎上,聯閤血液灌流,每2週1次.兩組共治療3箇月,治療前、後觀察患者的皮膚瘙癢改善情況,檢測血液中甲狀徬腺激素、β2微毬蛋白、燐離子、鈣離子的變化.結果 血液透析加血液灌流組患者血中的甲狀徬腺激素[( 314.5±182.4 )ng/L vs.( 479.2±207.1) ng/L]、β2微毬蛋白[(16.1±7.3) mg/L vs.(24.2±11.2) mg/L]、燐離子[(2.03±0.91) mmol/L vs.( 2.81±1.42) mmol/L)]明顯低于血液透析組(P＜0.05),也較治療前明顯下降(P＜ 0.05),皮膚瘙癢明顯改善(24/30),且無不良反應.血液透析組皮膚瘙癢無l例改善,治療前、後甲狀徬腺激素、β2微毬蛋白、燐離子無明顯變化(P＞ 0.05).兩組患者血中鈣離子無明顯變化(P＞ 0.05).結論 血液透析聯閤血液灌流是尿毒癥維持性血液透析患者皮膚瘙癢的有效治療方法.
목적 탐토혈액투석연합혈액관류치료뇨독증유지성혈액투석환자피부소양적료효.방법 선택아원뇨독증병피부소양적유지성혈액투석환자55례,수궤분위혈액투석조화혈액투석가혈액관류조.혈액투석조25례,접수상규투석치료,매주2～3차.혈액투석가혈액관류조30례,재혈액투석조치료적기출상,연합혈액관류,매2주1차.량조공치료3개월,치료전、후관찰환자적피부소양개선정황,검측혈액중갑상방선격소、β2미구단백、린리자、개리자적변화.결과 혈액투석가혈액관류조환자혈중적갑상방선격소[( 314.5±182.4 )ng/L vs.( 479.2±207.1) ng/L]、β2미구단백[(16.1±7.3) mg/L vs.(24.2±11.2) mg/L]、린리자[(2.03±0.91) mmol/L vs.( 2.81±1.42) mmol/L)]명현저우혈액투석조(P＜0.05),야교치료전명현하강(P＜ 0.05),피부소양명현개선(24/30),차무불량반응.혈액투석조피부소양무l례개선,치료전、후갑상방선격소、β2미구단백、린리자무명현변화(P＞ 0.05).량조환자혈중개리자무명현변화(P＞ 0.05).결론 혈액투석연합혈액관류시뇨독증유지성혈액투석환자피부소양적유효치료방법.
Objective To explore the curative effect of treating uremia skin-itch with hemodialysis and hemoperfuison.Methods Chose 55 uremia patients taking persistent hemodialysis and having skin-itch; ramdomly divided them into hemodialysis group and hemodialysis combined with hemoperfusion group.25 patients of the hemodialysis group took hemodialysis 2 to 3 times per week.Basing on the treatment of the hemodialysis group,the hemodialysis combined with hemoperfusion group took hemoperfusion every other week.Both groups were treated for 3 months.Observed all patients' skin-itch meliortion.Tested the change of parathyroid hormone,β 2 microglobulin,P,and Ca2+ in blood.Results The patients of hemodialysis combined with hemoperfusion group had lower parathyroid hormone[( 314.5± 182.4) ng/L vs.479.2 ± 207.1ng/L],β 2microglobulin[( 16.1 ± 7.3) mg/Lvs.(24.2 ± 11.2) mg/L],and P3- [( 2.03 ± 0.91 )mmol/L vs.( 2.81 ± 1.42 )mmol/L )]in blood than the patients of hemodialysis group ( P ＜ 0.05 ) and that before treatment ( P ＜ 0.05 ),and got some obvious improvement on skin-itch ( 24/30 ).No patients in hemodialysis group got obvious improvement on skin-itch.Blood parathyroid hormone,β 2 microglobulin,and p3- had no obvious change in the patients of hemodialysis group( P＞0.05 ).Patients' blood Ca2+ in both groups had no obvious change( P＞ 0.05 ).Conclusion Hemodialysis combined with hemoperfusion is an effective treatment method for the uremia patients taking persistent dialysis and having skin-itch.
