CAJ | 학술논문

目的探讨他克莫司在肾移植患者的临床疗效及术后的血药浓度.方法肾移植术患者54例,随机分为观察组和对照组,对照组口服环孢素A,观察组口服他克莫司.比较研究两组的临床疗效,并检测观察组的不同时期的血药浓度.结果与对照组相比,观察组血清直接胆红素(D-BILI)、总胆红素(T-BILI)浓度显著降低,急性排斥反应和感染比率明显降低,差异均有统计学意义(P<0.05);同时,观察组患者他克莫司血药浓度在术后不同时期均有差别.结论他克莫司有望发展为主要的免疫抑制剂,对其血药浓度影响因素的进一步研究,将有利于为临床器官移植患者提供合理的用药方案.
목적 탐토타극막사재신이식환자적림상료효급술후적혈약농도.방법 신이식술환자54례,수궤분위관찰조화대조조,대조조구복배포소A,관찰조구복타극막사.비교연구량조적림상료효,병검측관찰조적불동시기적혈약농도.결과 여대조조상비,관찰조혈청직접담홍소(D-BILI)、총담홍소(T-BILI)농도현저강저,급성배척반응화감염비솔명현강저,차이균유통계학의의(P<0.05);동시,관찰조환자타극막사혈약농도재술후불동시기균유차별.결론 타극막사유망발전위주요적면역억제제,대기혈약농도영향인소적진일보연구,장유리우위림상기관이식환자제공합리적용약방안.
Objective To study the clinical efficacy and plasma concentrations of tacrolimus in renal transplant patients. Methods Kidney transplant patients were randomly divided into experimental group and control group. Control group was treated with cyclosporin A, experimental group was treated with tacrolimus. Clinical efficacy of two groups was compared,and plasma concentrations of tacrolimus the experimental group were tested at different periods. Results Compared with the control group,experimental group D-BILI and the concentration of T-BILI significantly lower,rate of acute rejection and infection significantly reduced,the differences were statistically significant (P <0.05) ;At the same time,in the experimental group,blood concentration of FK506 in patients at different periods after surgery were different. Conclusions . Tacrolimus was expected to develop ithe main immunosuppressant, its blood concentration factors of further research would be beneficial for to provide a reasonable regimen the clinical organ transplant patients.