中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
12期
1498-1499
,共2页
颜新彦%王光%姜好%王寅%陆亚莉%杨林兴
顏新彥%王光%薑好%王寅%陸亞莉%楊林興
안신언%왕광%강호%왕인%륙아리%양림흥
慢性阻塞性肺疾病急性加重期%血浆N端脑利钠肽前体%心肌肌钙蛋白I
慢性阻塞性肺疾病急性加重期%血漿N耑腦利鈉肽前體%心肌肌鈣蛋白I
만성조새성폐질병급성가중기%혈장N단뇌리납태전체%심기기개단백I
Acute exacerbation of chronic obstructive pulmonary disease%N-terminal pro-brain%Cardiac tropnin-I
目的 探讨慢性阻塞性肺疾病急性加重期(AECOPD)合并Ⅱ型呼吸衰竭患者血浆N端脑钠肽前体(NT-proBNP)和心肌肌钙蛋白I(cTnI)的水平及临床意义.方法 选择80例确诊为AECOPD患者,单纯AECOPD患者40例为对照组,AECOPD合并Ⅱ型呼吸衰竭组40例为研究组.用电化学发光法测定血浆NT-proBNP及cTnI,并同步进行血气分析、肺功能检查,心脏超声多普勒测定三尖瓣反流速度估测肺动脉收缩压,比较其差异.结果 研究组与对照组的NT-proBNP水平分别为(478±44)、(61±10) ng/L,sPAP水平分别为(63±15)、(26±5)mm Hg(1 mm Hg =0.133 kPa),cTnI水平分别为(0.40±0.09)、(0.06±0.01) μg/L,PaO2水平分别为(50±4)、(70±6)mm Hg.2组差异均有统计学意义(均P＜0.05).研究组血浆NT-proB-NP与肺动脉收缩压呈正相关(r=0.75,P＜0.05),与cTnI呈正相关(r=0.65,P＜0.05),与PaO2呈负相关(r=-0.73,P＜0.05).结论 血浆NT-proBNP、cTnI对指导AECOPD治疗及评价患者预后有指导意义.
目的 探討慢性阻塞性肺疾病急性加重期(AECOPD)閤併Ⅱ型呼吸衰竭患者血漿N耑腦鈉肽前體(NT-proBNP)和心肌肌鈣蛋白I(cTnI)的水平及臨床意義.方法 選擇80例確診為AECOPD患者,單純AECOPD患者40例為對照組,AECOPD閤併Ⅱ型呼吸衰竭組40例為研究組.用電化學髮光法測定血漿NT-proBNP及cTnI,併同步進行血氣分析、肺功能檢查,心髒超聲多普勒測定三尖瓣反流速度估測肺動脈收縮壓,比較其差異.結果 研究組與對照組的NT-proBNP水平分彆為(478±44)、(61±10) ng/L,sPAP水平分彆為(63±15)、(26±5)mm Hg(1 mm Hg =0.133 kPa),cTnI水平分彆為(0.40±0.09)、(0.06±0.01) μg/L,PaO2水平分彆為(50±4)、(70±6)mm Hg.2組差異均有統計學意義(均P＜0.05).研究組血漿NT-proB-NP與肺動脈收縮壓呈正相關(r=0.75,P＜0.05),與cTnI呈正相關(r=0.65,P＜0.05),與PaO2呈負相關(r=-0.73,P＜0.05).結論 血漿NT-proBNP、cTnI對指導AECOPD治療及評價患者預後有指導意義.
목적 탐토만성조새성폐질병급성가중기(AECOPD)합병Ⅱ형호흡쇠갈환자혈장N단뇌납태전체(NT-proBNP)화심기기개단백I(cTnI)적수평급림상의의.방법 선택80례학진위AECOPD환자,단순AECOPD환자40례위대조조,AECOPD합병Ⅱ형호흡쇠갈조40례위연구조.용전화학발광법측정혈장NT-proBNP급cTnI,병동보진행혈기분석、폐공능검사,심장초성다보륵측정삼첨판반류속도고측폐동맥수축압,비교기차이.결과 연구조여대조조적NT-proBNP수평분별위(478±44)、(61±10) ng/L,sPAP수평분별위(63±15)、(26±5)mm Hg(1 mm Hg =0.133 kPa),cTnI수평분별위(0.40±0.09)、(0.06±0.01) μg/L,PaO2수평분별위(50±4)、(70±6)mm Hg.2조차이균유통계학의의(균P＜0.05).연구조혈장NT-proB-NP여폐동맥수축압정정상관(r=0.75,P＜0.05),여cTnI정정상관(r=0.65,P＜0.05),여PaO2정부상관(r=-0.73,P＜0.05).결론 혈장NT-proBNP、cTnI대지도AECOPD치료급평개환자예후유지도의의.
Objective To study the change and the singifiance of N-terminal pro-B natriuretic peptide (NT-proBNP) and cardiac tropnin-I( cTnI )in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with respiratory failure.Methods Totolly 80 hospitalized AECOPD patients were divided into the pure AECOPD group and the AECOPD with respiratory failure group,N-terminal pro-brain and TnI was measured by using electrochem inescence law and the difference was compared finally.Results N-terminal pro-brain and TnI in the AECOPD with respiratory failure group was higher than that in the pure AECOPD group( P ＜ 0.05 ),N-terminal pro-brain levels were positively correlated with pulmonary arterial systolic pressure ( r = 0.75,P ＜ 0.05 ) and cTnI ( r =0.65,P ＜ 0.05 ),N-terminal pro-brain levels were negatively correlated with PaO2 ( r = -0.73,P ＜ 0.05 ).Conclusion Deteming the level of N-terminal pro-brain and cTnI can be helpful of judging the severity degree and prognosis in AECOPD.
