中药新药与临床药理
中藥新藥與臨床藥理
중약신약여림상약리
TRADITIONAL CHINESE DRUG RESEARCH&CLINICAL PHARMACOLOGY
2009年
4期
383-385
,共3页
汤建成%王溶溶%陈丹菲%潘建明
湯建成%王溶溶%陳丹菲%潘建明
탕건성%왕용용%진단비%반건명
糖足颗粒%正交试验%工艺研究
糖足顆粒%正交試驗%工藝研究
당족과립%정교시험%공예연구
Tangzu granula%Orthogonal design%Process research
目的 研究糖足颗粒的制备工艺.方法 以出膏率和芍药苷总量为指标,正交试验法优选水提条件;以颗粒吸湿性、流动性和成型性为指标,筛选颗粒最佳辅料与配比.结果 最佳水提工艺为药材加10倍量水,煎煮2次,每次1.5 h;制备糖足颗粒的最优处方组成为:2份浸膏与3份辅料(乳糖:糊精=2:1的混合辅料)混合制粒.结论 该工艺科学合理,简便实用,质量稳定.
目的 研究糖足顆粒的製備工藝.方法 以齣膏率和芍藥苷總量為指標,正交試驗法優選水提條件;以顆粒吸濕性、流動性和成型性為指標,篩選顆粒最佳輔料與配比.結果 最佳水提工藝為藥材加10倍量水,煎煮2次,每次1.5 h;製備糖足顆粒的最優處方組成為:2份浸膏與3份輔料(乳糖:糊精=2:1的混閤輔料)混閤製粒.結論 該工藝科學閤理,簡便實用,質量穩定.
목적 연구당족과립적제비공예.방법 이출고솔화작약감총량위지표,정교시험법우선수제조건;이과립흡습성、류동성화성형성위지표,사선과립최가보료여배비.결과 최가수제공예위약재가10배량수,전자2차,매차1.5 h;제비당족과립적최우처방조성위:2빈침고여3빈보료(유당:호정=2:1적혼합보료)혼합제립.결론 해공예과학합리,간편실용,질량은정.
Objective To optimize the preparation process of Tangzu Granula. Methods With the paste-forming rate and total content of paeoniflorin as the indexes, the optimal water-extraction condition was screened by orthogonal design. With hydroscopicity, fluidity and formability as the indexes, the appropriate ratio of the excipient and the formula were selected. Results The optimum water-extraction condition was as follows: 10-fold water, decoction for 2 times and 1.5 hour for each time. The optimal ratio of the excipient and the formula for preparation of Tangzu granules were two proportions of the extract and three proportions of the excipient which consisted of lactose and dextrin(2 : 1, w/ w). Conclusion The technology is effec-tive, scientific, reasonable, and practical.
