现代化工
現代化工
현대화공
MODERN CHEMICAL INDUSTRY
2010年
3期
44-45,47
,共3页
3,5-二甲基-4-羟基苯甲醛%3,5-二甲基-4-羟基苯甲腈%盐酸羟胺%N,N-二甲基甲酰胺%合成
3,5-二甲基-4-羥基苯甲醛%3,5-二甲基-4-羥基苯甲腈%鹽痠羥胺%N,N-二甲基甲酰胺%閤成
3,5-이갑기-4-간기분갑철%3,5-이갑기-4-간기분갑정%염산간알%N,N-이갑기갑선알%합성
3,5-dimethyl-4-hydroxybenzaldehyde%3,5-dimethyl-4-hydroxybenzonitrile%hydroxyamine hydrochloride%N,N-dimethylformamide%synthesis
以3,5-二甲基-4-羟基苯甲醛和盐酸羟胺为原料,分别在甲酸、乙酸和N,N-二甲基甲酰胺(DMF)中一步反应合成了3,5-二甲基-4-羟基苯甲腈.以DMF为溶剂的反应效果最好,最佳条件下收率达90%以上,粗品含量98%以上.
以3,5-二甲基-4-羥基苯甲醛和鹽痠羥胺為原料,分彆在甲痠、乙痠和N,N-二甲基甲酰胺(DMF)中一步反應閤成瞭3,5-二甲基-4-羥基苯甲腈.以DMF為溶劑的反應效果最好,最佳條件下收率達90%以上,粗品含量98%以上.
이3,5-이갑기-4-간기분갑철화염산간알위원료,분별재갑산、을산화N,N-이갑기갑선알(DMF)중일보반응합성료3,5-이갑기-4-간기분갑정.이DMF위용제적반응효과최호,최가조건하수솔체90%이상,조품함량98%이상.
A one-pot synthesis of 3,5-dimethyl-4-hydroxybenzonitrile from 3,5-dimethyl-4-hydroxybenzaldehyde and hydroxyamine hydrochloride in solvents such as formic acid,acetic acid,and N,N-dimethylformamide (DMF) is studied.The yields are optimal if in DMF,and the optimization of reaction conditions is carried out.Under such optimum conditions the yield of the nitrile can be 93%,with purity of above 98%,which are determined by HPLC.
