CAJ | 학술논문

目的探讨术后重症患者β细胞功能改变及其与预后的关系.方法 32.例术后入ICU患者年龄16岁且无糖尿病病史,根据APACHE Ⅱ评分是否10分,分为对照组和重症组.测定术前当日及术后第1天清晨空腹胰岛素(FINS)、空腹C肽(FCP)并计算HOMA-β细胞功能指数.结果重症组术后第1天FINS、FCP、HOMA-β细胞功能指数与术前当日比较差异均有统计学意义(均P<0.05),与对照组比较差异均有统计学意义(均P<0.05);术后第1天FINS、空腹C肽、HOMA-β细胞功能指数与APACHE Ⅱ评分、APACHEⅢ评分和住ICU天数高度负相关.结论术后重症患者可能存在胰岛β细胞功能不全.
목적 탐토술후중증환자β세포공능개변급기여예후적관계.방법 32.례술후입ICU환자년령16세차무당뇨병병사,근거APACHE Ⅱ평분시부10분,분위대조조화중증조.측정술전당일급술후제1천청신공복이도소(FINS)、공복C태(FCP)병계산HOMA-β세포공능지수.결과 중증조술후제1천FINS、FCP、HOMA-β세포공능지수여술전당일비교차이균유통계학의의(균P<0.05),여대조조비교차이균유통계학의의(균P<0.05);술후제1천FINS、공복C태、HOMA-β세포공능지수여APACHE Ⅱ평분、APACHEⅢ평분화주ICU천수고도부상관.결론 술후중증환자가능존재이도β세포공능불전.
Objective To evaluate the changes of β cell function in critically ill surgical patients and its re- lationship with prognosis.Methods 32 patients>16 years age with no history of diabetes who were admitted to sur- gical intensive care unit(SICU)were divided into two groups according to APACHE Ⅱ score.Blood sample Was taken on preoperative and postoprative 1st day for measures of fasting insulin(FINS)and fasting C peptide(FCP). The HOMA-β Was calculated.Results The level of FINS,FCP and HOMA-β were significantly decreased on first day after operation than preoperative in critical group.Compared with control group,The level of FINS.FCP and HO- MA-βwere significantly reduced on first day after operation-which had negative correlation with APACHE Ⅱ score, APACHE Ⅲ score and in charge days of ICU.Conclusion There is β cell dysfunction in critically ill Surgical pa- tients.β cell function in surgical critically ill patients is negatively correlated with APACHE Ⅱ SCOre-APACHE Ⅲ score and days of ICU.