中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2010年
4期
383-385
,共3页
糖尿病周围神经病变%银杏达莫%甲钴胺
糖尿病週圍神經病變%銀杏達莫%甲鈷胺
당뇨병주위신경병변%은행체막%갑고알
Diabetic peripheral neuropathy%Ginkgo leaf extract and dipyridamole injection%Methycobal
目的 观察银杏达莫和甲钴胺联合治疗糖尿病周围神经病变的临床疗效.方法 将我院2006年1月至2008年12月收治的82例糖尿病周围神经病变的患者随机分为3组,在控制血糖、降压、降血脂等治疗基础上,银杏达莫组给予银杏达莫20 ml/d,甲钴胺组给予甲钴胺500μg/d静脉滴注,联合用药组同时给予银杏达莫20 ml/d+甲钴胺500 μg/d静脉滴注,疗程均为4周.观察治疗前后3组患者临床症状、体征和神经传导速度的变化.结果 联合用药组总有效率达76.5%(26/34),银杏达莫组和甲钴胺组总有效率分别为44.O%(11/25)及34.8%(8/23),联合用药组与其他2组比较差异有统计学意义(P均<0.05);治疗后联合用药组神经传导速度较甲钴胺组和银杏达莫组明显改善(正中神经、腓总神经运动神经传导速度分别为(38.68±4.10)、(39.55±4.34)m/s与(34.35±2.74)、(32.78±2.66)m/s与(36.56±4.71)、(33.24±3.26)m/s;感觉神经传导速度分别为(37.44±4.42)、(34.26±4.01)m/s与(33.26±2.65)、(32.13±3.33)m/s与(34.80±4.43)、(31.04±4.62)m/s,P均<0.05).结论 银杏达莫联合甲钴胺可明显改善糖尿病周围神经病变的临床疗效.
目的 觀察銀杏達莫和甲鈷胺聯閤治療糖尿病週圍神經病變的臨床療效.方法 將我院2006年1月至2008年12月收治的82例糖尿病週圍神經病變的患者隨機分為3組,在控製血糖、降壓、降血脂等治療基礎上,銀杏達莫組給予銀杏達莫20 ml/d,甲鈷胺組給予甲鈷胺500μg/d靜脈滴註,聯閤用藥組同時給予銀杏達莫20 ml/d+甲鈷胺500 μg/d靜脈滴註,療程均為4週.觀察治療前後3組患者臨床癥狀、體徵和神經傳導速度的變化.結果 聯閤用藥組總有效率達76.5%(26/34),銀杏達莫組和甲鈷胺組總有效率分彆為44.O%(11/25)及34.8%(8/23),聯閤用藥組與其他2組比較差異有統計學意義(P均<0.05);治療後聯閤用藥組神經傳導速度較甲鈷胺組和銀杏達莫組明顯改善(正中神經、腓總神經運動神經傳導速度分彆為(38.68±4.10)、(39.55±4.34)m/s與(34.35±2.74)、(32.78±2.66)m/s與(36.56±4.71)、(33.24±3.26)m/s;感覺神經傳導速度分彆為(37.44±4.42)、(34.26±4.01)m/s與(33.26±2.65)、(32.13±3.33)m/s與(34.80±4.43)、(31.04±4.62)m/s,P均<0.05).結論 銀杏達莫聯閤甲鈷胺可明顯改善糖尿病週圍神經病變的臨床療效.
목적 관찰은행체막화갑고알연합치료당뇨병주위신경병변적림상료효.방법 장아원2006년1월지2008년12월수치적82례당뇨병주위신경병변적환자수궤분위3조,재공제혈당、강압、강혈지등치료기출상,은행체막조급여은행체막20 ml/d,갑고알조급여갑고알500μg/d정맥적주,연합용약조동시급여은행체막20 ml/d+갑고알500 μg/d정맥적주,료정균위4주.관찰치료전후3조환자림상증상、체정화신경전도속도적변화.결과 연합용약조총유효솔체76.5%(26/34),은행체막조화갑고알조총유효솔분별위44.O%(11/25)급34.8%(8/23),연합용약조여기타2조비교차이유통계학의의(P균<0.05);치료후연합용약조신경전도속도교갑고알조화은행체막조명현개선(정중신경、비총신경운동신경전도속도분별위(38.68±4.10)、(39.55±4.34)m/s여(34.35±2.74)、(32.78±2.66)m/s여(36.56±4.71)、(33.24±3.26)m/s;감각신경전도속도분별위(37.44±4.42)、(34.26±4.01)m/s여(33.26±2.65)、(32.13±3.33)m/s여(34.80±4.43)、(31.04±4.62)m/s,P균<0.05).결론 은행체막연합갑고알가명현개선당뇨병주위신경병변적림상료효.
Objective To investigate the effects of ginkgo leaf extract and dipyridamole injection combined with methycobal in treating diabetic peripheral neuropathy (DPN).Methods From Jan.2006 to Dec.2008 in our hospital,Eighty-two patients with DPN were divided randomly into 3 groups:Group A (treated with ginkgo leaf extract and dipyridamole injection 20 ml/d saline dropping),group B (treated with methycobal 500 μg/d for 4 weeks),and group C(treated with 20 ml/d ginkgo leaf extract and dipyridamole injection and methycobal 500 μg/d with normal saline liquid vein dropping for 4 weeks).Clinic symptom,physical sign and nerve conduction velocity (NCV) were assessed before and after treatment.Results The total effective rate was higher in group C (76.5%,26/34) than that in group A (44.O%,11/25) and group B (34.8%,8/23)(P<O.05).After treatment in group C,B and A,the motor nerve conduction velocity(MNCV) of median nerve was (38.68±4.10)m/s,(34.35±2.74)m/s and (36.56±4.71)m/s,the MVCN of nervus peroneus communis was (39.55±4.34)m/s,(32.78±2.66) m/s and (33.24±3.26) m/s,the sensory nerve conduction velocity (SNCV) of median nerve was (37.44±4.42)m/s,(33.26±2.65)m/s and (34.80±4.43)m/s,and the SNCV of nervus peroneus communis was (34.26±4.01)m/s,(32.13±3.33)m/s and (31.04±4.62)m/s.The improvement of NCV in group C was better thanthat of group A and B (P<0.05).Conclusions Ginkgo leaf extract and dipyridamole injection combined with methycobal can significantly improve the clinical efficiency of diabetic peripheral neuropathy.
