中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2010年
3期
218-220
,共3页
刘传朋%王学义%刘小玉%谭莉%任会鹏%王岚
劉傳朋%王學義%劉小玉%譚莉%任會鵬%王嵐
류전붕%왕학의%류소옥%담리%임회붕%왕람
青少年%双相障碍%执行功能%对照研究
青少年%雙相障礙%執行功能%對照研究
청소년%쌍상장애%집행공능%대조연구
Adolescents%Bipolar disorder%Executive function%Control study
目的 研究青少年双相障碍患者的执行功能特点及其影响因素.方法 采用威斯康星卡片分类测验(WCST)、Stroop色词测验(SCW)、空间广度测验、数字序列测验和伦敦塔测验分别对30例青少年双相抑郁发作患者和30例青少年双相躁狂发作患者(研究组)以及30名健康青少年(对照组)进行执行功能评估.结果 (1)治疗前后,研究组全部执行功能指标与对照组比较,差异均具有统计学意义(P<0.01).治疗前,抑郁发作组和躁狂发作组WCST中的非持续性错误数(NRPE)、完成第一个分类的应答数(RF)以及SCW中的卡片A、卡片B、卡片C的反应时间(RTA、RTB、RTC),以及干扰效应反应时(SIE)等,差异具有统计学意义[NRPE:(27.30±5.19)个,(31.77±6.13)个;RF:(30.60±7.41)个,(35.33±9.06)个;RTA:(53.40±8.97)s,(63.63±8.85)s;RTB:(81.93±8.44)s,(93.87±6.98)s;RTC:(127.27±12.52)s,(160.27±13.70)s;SIE:(45.33±13.90)s,(66.40±13.56 s),P<0.05或P<0.01].治疗8周后,抑郁发作组和躁狂发作组的RF、TOL、RTA、RTB、RTC以及SIE等指标,差异具有统计学意义(P<0.05或P<0.01).除RTA和RTB外,治疗后抑郁组的其他执行功能测验成绩与治疗前的差异有统计学意义(P<0.01).治疗后躁狂组全部执行功能指标与治疗前比较差异具有统计学意义(P<0.01).(2)伦敦塔测验和分类数(CC)与病程呈负相关(均P<0.05),持续错误数(RPE)、NRPE和RF以及SIE等指标与病程呈正相关(均P<0.05).结论 青少年双相障碍患者在整个疾病过程中存在执行功能障碍.
目的 研究青少年雙相障礙患者的執行功能特點及其影響因素.方法 採用威斯康星卡片分類測驗(WCST)、Stroop色詞測驗(SCW)、空間廣度測驗、數字序列測驗和倫敦塔測驗分彆對30例青少年雙相抑鬱髮作患者和30例青少年雙相躁狂髮作患者(研究組)以及30名健康青少年(對照組)進行執行功能評估.結果 (1)治療前後,研究組全部執行功能指標與對照組比較,差異均具有統計學意義(P<0.01).治療前,抑鬱髮作組和躁狂髮作組WCST中的非持續性錯誤數(NRPE)、完成第一箇分類的應答數(RF)以及SCW中的卡片A、卡片B、卡片C的反應時間(RTA、RTB、RTC),以及榦擾效應反應時(SIE)等,差異具有統計學意義[NRPE:(27.30±5.19)箇,(31.77±6.13)箇;RF:(30.60±7.41)箇,(35.33±9.06)箇;RTA:(53.40±8.97)s,(63.63±8.85)s;RTB:(81.93±8.44)s,(93.87±6.98)s;RTC:(127.27±12.52)s,(160.27±13.70)s;SIE:(45.33±13.90)s,(66.40±13.56 s),P<0.05或P<0.01].治療8週後,抑鬱髮作組和躁狂髮作組的RF、TOL、RTA、RTB、RTC以及SIE等指標,差異具有統計學意義(P<0.05或P<0.01).除RTA和RTB外,治療後抑鬱組的其他執行功能測驗成績與治療前的差異有統計學意義(P<0.01).治療後躁狂組全部執行功能指標與治療前比較差異具有統計學意義(P<0.01).(2)倫敦塔測驗和分類數(CC)與病程呈負相關(均P<0.05),持續錯誤數(RPE)、NRPE和RF以及SIE等指標與病程呈正相關(均P<0.05).結論 青少年雙相障礙患者在整箇疾病過程中存在執行功能障礙.
목적 연구청소년쌍상장애환자적집행공능특점급기영향인소.방법 채용위사강성잡편분류측험(WCST)、Stroop색사측험(SCW)、공간엄도측험、수자서렬측험화륜돈탑측험분별대30례청소년쌍상억욱발작환자화30례청소년쌍상조광발작환자(연구조)이급30명건강청소년(대조조)진행집행공능평고.결과 (1)치료전후,연구조전부집행공능지표여대조조비교,차이균구유통계학의의(P<0.01).치료전,억욱발작조화조광발작조WCST중적비지속성착오수(NRPE)、완성제일개분류적응답수(RF)이급SCW중적잡편A、잡편B、잡편C적반응시간(RTA、RTB、RTC),이급간우효응반응시(SIE)등,차이구유통계학의의[NRPE:(27.30±5.19)개,(31.77±6.13)개;RF:(30.60±7.41)개,(35.33±9.06)개;RTA:(53.40±8.97)s,(63.63±8.85)s;RTB:(81.93±8.44)s,(93.87±6.98)s;RTC:(127.27±12.52)s,(160.27±13.70)s;SIE:(45.33±13.90)s,(66.40±13.56 s),P<0.05혹P<0.01].치료8주후,억욱발작조화조광발작조적RF、TOL、RTA、RTB、RTC이급SIE등지표,차이구유통계학의의(P<0.05혹P<0.01).제RTA화RTB외,치료후억욱조적기타집행공능측험성적여치료전적차이유통계학의의(P<0.01).치료후조광조전부집행공능지표여치료전비교차이구유통계학의의(P<0.01).(2)륜돈탑측험화분류수(CC)여병정정부상관(균P<0.05),지속착오수(RPE)、NRPE화RF이급SIE등지표여병정정정상관(균P<0.05).결론 청소년쌍상장애환자재정개질병과정중존재집행공능장애.
Objective To study the executive function and the related factors before and after therapy.Methods Thirty adolescents with depressed bipolar patients and 30 adolescents with manic bipolar patients (study group),thirty health adolescents controls(control group)were assessed for executive function using the Wisconsin Card Sorting Test(WCST),the Stroop Color Word Test(SCW),the Tower of London Test,the Digital Sequence Test and Spatial Span Test.Neuropsychological assessment was performed respectively in the 1st week of entering the group and the end of the 8th week.Results Before and after the treatment the study group performed poorer on all of the neuropsyehological tests than control group(P<0.01).Furthermore,follow-up assessment revealed that although study group demonstrated an overall improvement,the deficits in executive functions remain.Manic bipolar patients showed the worse performance than depressed bipolar patients on subtests reflecting inhibitory control before treatment(NRPE:27.30±5.19 vs 31.77±6.13;R F:30.60±7.41 vs 35.33±9.06;RTA:(53.40±8.97)s vs(63.63±8.85)s;RTB:(81.93±8.44)s vs(93.87±6.98)s;RTC:(127.27±12.52)s vs(160.27±13.70)s;SIE:(45.33±13.90)s vs(66.40±13.56)s,P<0.01 or P<0.05).After 8 weeks treatment,there were remarkable differences between depressed bipolar group and mania bipolar group on RF,TOL,RTA,RTB,RTC,SIE(P<0.01 or P<0.05).Self-comparison of the depressed bipolar on nenropsychological performance before and after treatment showed significant difference(P<0.01),except RTA and RTB of the SCW (P>0.05).Self-comparisen of the manic bipolar on neuropsychological performance before and after treatment showed significant difference(P<0.01).The Tower of London test and the number of categories of WCST were negatively correlated to the course of disease(P<0.05);Perseverative Errors score,Non-Perseverative Errors score and the Responses of Finishing the first Category of WCST and the Interference of Stroop were positive correlated to the course of disease(P<0.05).Conclusion The impairment of executive function in young patients with bipolar disorder is observed in the period of disease,which could improve after treatment.