CAJ | 학술논문

目的探讨餐后血糖水平与冠心病发生的相关性.方法选择血糖水平异常并已行冠状动脉造影的患者85例,按血糖水平将患者分为三组:空腹血糖调节受损(IFG)组28例、糖耐量减低(IGT)组29例及糖尿病(DM)组28例,观察各组冠心病发生率及冠状动脉病变程度,分析三组患者C反应蛋白(CRP)、颈动脉内膜中层厚度(CIMT)、血脂、血压、体重指数(BMI)的变化及与冠心病危险因素的相关性.结果 IGT组和DM组冠心病发生率[分别为79.3%(23/29)、85.7%(24/28)]明显高于IFG组[53.6%(15/28)](P＜0.01),DM组冠心病发生率高于IGT组,但差异无统计学意义(P＞0.05).IGT组和DM组2支病变、3支病变发生率均高于IFG组(P＜0.01),DM组2支病变、3支病变发生率高于IGT组,但差异无统计学意义(P＞0.05).IGT组、DM组CRP、CIMT、BMI、三酰甘油(TG)、收缩压(SBP)较IFG组明显升高(P＜0.01或＜0.05),高密度脂蛋白胆固醇(HDL-C)较IFG组明显降低(P＜0.01);DM组CRP、TG、SBP较IGT组升高(P＜0.05),其他指标比较差异无统计学意义(P＞0.05);相关性分析表明,IGT组和DM组餐后2 h血糖与CRP、CIMT、BMI、TG呈显著正相关(P＜0.05或＜0.01),与HDL-C呈显著负相关(P＜0.05或＜0.01).结论餐后高血糖与冠心病的发生、发展有密切关系,对于IGT患者应尽早予以干预治疗,可有效预防心血管事件的发生.
목적 탐토찬후혈당수평여관심병발생적상관성.방법 선택혈당수평이상병이행관상동맥조영적환자85례,안혈당수평장환자분위삼조:공복혈당조절수손(IFG)조28례、당내량감저(IGT)조29례급당뇨병(DM)조28례,관찰각조관심병발생솔급관상동맥병변정도,분석삼조환자C반응단백(CRP)、경동맥내막중층후도(CIMT)、혈지、혈압、체중지수(BMI)적변화급여관심병위험인소적상관성.결과 IGT조화DM조관심병발생솔[분별위79.3%(23/29)、85.7%(24/28)]명현고우IFG조[53.6%(15/28)](P＜0.01),DM조관심병발생솔고우IGT조,단차이무통계학의의(P＞0.05).IGT조화DM조2지병변、3지병변발생솔균고우IFG조(P＜0.01),DM조2지병변、3지병변발생솔고우IGT조,단차이무통계학의의(P＞0.05).IGT조、DM조CRP、CIMT、BMI、삼선감유(TG)、수축압(SBP)교IFG조명현승고(P＜0.01혹＜0.05),고밀도지단백담고순(HDL-C)교IFG조명현강저(P＜0.01);DM조CRP、TG、SBP교IGT조승고(P＜0.05),기타지표비교차이무통계학의의(P＞0.05);상관성분석표명,IGT조화DM조찬후2 h혈당여CRP、CIMT、BMI、TG정현저정상관(P＜0.05혹＜0.01),여HDL-C정현저부상관(P＜0.05혹＜0.01).결론 찬후고혈당여관심병적발생、발전유밀절관계,대우IGT환자응진조여이간예치료,가유효예방심혈관사건적발생.
Objective To investigate the correlation between the level of postprandial blood glucose (PBG)and the incidence of coronary artery disease(CAD). Methods Eighty-five patients performed coronary angiography with abnormal blood glucose levels were divided into 3 groups according the blood glucose levels: impaired fasting glucose(IFG)group(28 cases), impaired glucose tolerance(IGT)group(29cases)and diabetes mellitus(DM)group(28 cases). The detection rate and the extent of CAD were observed. The risk factors of CAD in 3 groups such as C-reactive protein(CRP),carotid artery intima-media thickness(CIMT), blood lipids, blood pressure, body mass index(BMI)and the correlation with CAD were analyzed. Results Sixty-two cases were confirmed CAD by coronary angiography. The incidence rate of CAD in IGT group[79.3%(23/29)]and DM group[85.7%(24/28)]was significantly higher than that in IFG group[53.6%(15/28)](P ＜ 0.01). The incidence rate of CAD in DM group was higher than that in IGT group, but there was no significant difference(P ＞ 0.05). The incidence rate of two-lesion and three-lesion in IGT group and DM group were significantly higher than those in IFG group(P＜ 0.01). The incidence rate of two-lesion and three-lesion in DM group were higher than those in IGT group, but there was no significant difference(P＞0.05). The levels of CRP, CIMT, BMI, triacylglycerol(TG)and systolic blood pressure(SBP)were higher and HDL-C was lower in IGT group and DM group than those in IFG group(P ＜ 0.01 or ＜ 0.05).The levels of CRP,TG and SBP were higher in DM group than those in IGT group(P＜0.05). Correlation analysis showed, in IGT group and DM group,2 h PG had significantly positive correlation with CRP, CIMT,B MI, TG(P＜0.05 or＜0.01), and had significantly negative correlation with HDL-C(P＜0.05 or ＜0.01).Conclusions PBG is closely related with the development of CAD.IGT patients should be intervened as early as possible, which can be effective in preventing cardiovascular events.