CAJ | 학술논문

目的观察依达拉奉联合益肾定眩汤治疗急性后循环脑梗死的临床疗效. 方法选择自2010年1月至201 1年6月望京医院收治的急性后循环脑梗死患者63例,按随机数字表法分为治疗组(32例)和对照组(31例).治疗组予依达拉奉静脉输注联合自拟方益肾定眩汤(天麻、钩藤、川芎、鸡血藤、白术、泽泻、半夏、山萸肉、黄芪、枸杞、何首乌等组成)口服,对照组予依达拉奉联合疏血通静脉输注.2组患者均在治疗前和治疗14d后应用美国国立卫生研究院神经功能缺损评分量表(NIHSS)评分,并以评分改善(NIHSS评分减少)程度作为疗效评价指标. 结果治疗14d后治疗组NIHSS评分(4.564±1.350)与对照组(7.976±1.830)比较差异有统计学意义(t=6.587,P=0.021).秩和检验发现疗效等级分布在2组间比较差异有统计学意义(Z=-2.338.P=0.019).进一步经平均秩次(治疗组26.89.对照组37.27)判断治疗组疗效优于对照组. 结论应用依达拉奉联合益肾定眩汤治疗急性后循环脑梗死具有较好疗效.
목적 관찰의체랍봉연합익신정현탕치료급성후순배뇌경사적림상료효. 방법 선택자2010년1월지201 1년6월망경의원수치적급성후순배뇌경사환자63례,안수궤수자표법분위치료조(32례)화대조조(31례).치료조여의체랍봉정맥수주연합자의방익신정현탕(천마、구등、천궁、계혈등、백술、택사、반하、산유육、황기、구기、하수오등조성)구복,대조조여의체랍봉연합소혈통정맥수주.2조환자균재치료전화치료14d후응용미국국립위생연구원신경공능결손평분량표(NIHSS)평분,병이평분개선(NIHSS평분감소)정도작위료효평개지표. 결과 치료14d후치료조NIHSS평분(4.564±1.350)여대조조(7.976±1.830)비교차이유통계학의의(t=6.587,P=0.021).질화검험발현료효등급분포재2조간비교차이유통계학의의(Z=-2.338.P=0.019).진일보경평균질차(치료조26.89.대조조37.27)판단치료조료효우우대조조. 결론 응용의체랍봉연합익신정현탕치료급성후순배뇌경사구유교호료효.
Objective To observe the treatment efficacy of Edaravone and Yishen Dingxuan decoction on patients with posterior circulation infarction. Methods Sixty-three patients with posterior circulation infarction,admitted to our hospital from January 2010 to June 2011,were randomly divided into treatment group (n=32) and control group (n=31); treatment group was treated by Edaravone (intravenous infusion) and Yishen Dingxuan decoction (per os),and Yishen Dingxuan decoction was composed of Tianma,Gouteng,Chuanxiong,Jixueteng,Baizhu,Zexie,Banxia,Shanyurou,Huangqi,Gouqi and Heshouwu.Control group was treated by edaravone (intravenous infusion) and Shuxuetong.National Institutes of Health Stroke Scale (NIHSS) was performed before and 14 d after the treatment; the decrement of the scores (the symptom improvement degree) was used as index to evaluate the efficacy.Results The NIHSS scores in the treatment group (4.564 ±1.350) were significantly different as compared with those in the control group ([7.976+ 1.830],t=6.587,P=0.021 ).Rank-sum test indicated that grade distribution of the efficacy between the 2 groups was significantly different (Z=-2.338,P=0.019),and mean rank test further proved that the treatment efficacy in treatment group (26.89) was better than that in the control group (37.27) Conclusion The treatment efficacy of Edaravone and Yishen Dingxuan decoction in patients with posterior circulation infarction is good.