CAJ | 학술논문

目的建立同系大鼠原位肺移植模型,评价Cuff 套管技术应用效果.方法采取两名手术者同时、分别行供受体手术的方法,行左侧同系原位大鼠肺移植22例,肺动脉、肺静脉、主支气管吻合均采用非缝合的Cuff套管技术,评价其可行性和可靠性.结果移植手术成功率90.9%(20/22),移植物缺血时间、热缺血时间和总的手术时间分别为(42.5±2.3)min,(17.1±3.6)min和(68.7±5.1)min.同系大鼠移植术后3周以内(12/22)通气和血流灌注良好,手术后6个月(3/22)、9个月(3/22)、12个月后(2/22)移植肺显示通气不良但吻合口开放.结论大鼠原位肺移植模型采用非缝合的Cuff套管技术行支气管和血管吻合简便、快速和可靠,支气管吻合后能够保持较长时间的管腔开放.
목적 건립동계대서원위폐이식모형,평개Cuff 투관기술응용효과.방법 채취량명수술자동시、분별행공수체수술적방법,행좌측동계원위대서폐이식22례,폐동맥、폐정맥、주지기관문합균채용비봉합적Cuff투관기술,평개기가행성화가고성.결과 이식수술성공솔90.9%(20/22),이식물결혈시간、열결혈시간화총적수술시간분별위(42.5±2.3)min,(17.1±3.6)min화(68.7±5.1)min.동계대서이식술후3주이내(12/22)통기화혈류관주량호,수술후6개월(3/22)、9개월(3/22)、12개월후(2/22)이식폐현시통기불량단문합구개방.결론 대서원위폐이식모형채용비봉합적Cuff투관기술행지기관화혈관문합간편、쾌속화가고,지기관문합후능구보지교장시간적관강개방.
Objective To estimate whether cuff technique can well be employed for rat left lung transplantation.Methods Orthotopic left lung transplantation was performed on 22 rats with nonsuture cuff technique by two persons who operated on the donors and recipients simultaneously and separately.The feasibility and reliability of this technique was determined.Results The success rate of transplant operation was 90.0% (20/22).Graft ischemic time,warm ischemic time and total operative time was (42.5±2.3) min,(17.1±3.6) min and (68.7±5.1) min respectively.Isografts at 3rd week (14/22) looked well perfused and ventilated,and over 6 months (3/22),9 months (3/22) and 12 months (2/22) all demonstrated ventilation but looked hypoperfused.Conclusion The nonsuture external cuff technique is a reliable,simple and fast method for performing orthotopic left lung transplantation in the rat.In contrast to earlier reports patency of the bronchus was found even at long term.