CAJ | 학술논문

目的评价大剂量碘化油经肝动脉化疗栓塞(TACE)对兔VX2肝移植瘤生长及转移的影响.方法 48只荷VX2肝移植瘤兔随机分成三组,每组16只.A组为对照组:经肝动脉灌注0.5 ml生理盐水;B组为常规剂量碘化油TACE组(常规剂量组):经肝动脉灌注5 mg阿霉素与常规剂量碘化油的混悬液;C组为大剂量碘化油TACE组(大剂量组):经肝动脉灌注5mg阿霉素与大剂量碘化油的混悬液.B组和C组碘化油用量(ml)分别为肿瘤体积(cm~3)乘以0.5和1.经股动脉穿刺插管,依分组情况行介入治疗,比较不同处理组肝移植瘤TACE后2周的增长率、坏死率及肝内转移、肺转移的发生率.结果介入治疗前各组肿瘤平均体积之间无显著性差异(P>0.05);介入治疗后常规剂量组及大剂量组肿瘤增长率明显降低(P<0.01),大剂量组肿瘤增长率降低更为明显(P<0.01);与常规剂量组肿瘤的坏死率相比,大剂量组肿瘤的坏死率明显增加(P<0.01);大剂量组肿瘤肝内转移、肺转移的发生率明显降低(P<0.05).结论大剂量碘化油TACE能明显抑制兔VX2肝移植瘤的生长与转移.
목적 평개대제량전화유경간동맥화료전새(TACE)대토VX2간이식류생장급전이적영향.방법 48지하VX2간이식류토수궤분성삼조,매조16지.A조위대조조:경간동맥관주0.5 ml생리염수;B조위상규제량전화유TACE조(상규제량조):경간동맥관주5 mg아매소여상규제량전화유적혼현액;C조위대제량전화유TACE조(대제량조):경간동맥관주5mg아매소여대제량전화유적혼현액.B조화C조전화유용량(ml)분별위종류체적(cm~3)승이0.5화1.경고동맥천자삽관,의분조정황행개입치료,비교불동처리조간이식류TACE후2주적증장솔、배사솔급간내전이、폐전이적발생솔.결과 개입치료전각조종류평균체적지간무현저성차이(P>0.05);개입치료후상규제량조급대제량조종류증장솔명현강저(P<0.01),대제량조종류증장솔강저경위명현(P<0.01);여상규제량조종류적배사솔상비,대제량조종류적배사솔명현증가(P<0.01);대제량조종류간내전이、폐전이적발생솔명현강저(P<0.05).결론 대제량전화유TACE능명현억제토VX2간이식류적생장여전이.
Objective To evaluate the effect of transcatheter arterial chemoembolization (TACE) with high-dose iodized oil on hepatic tumor growth and metastasis in rabbits. Methods Forty-eight rabbits with implanted VX2 tumor were randomly divided into control group, routine dose iodized oil TACE group and high-dose iodized oil TACE group to receive perfusion through the hepatic artery with 0.9% saline, 5 mg adriamycin with routine-dose iodized oil, and 5 mg adriamycin with high-dose iodized oil, respectively. The tumor volume, tumor necrosis, intrahepatic and lung metastasis were examined 2 weeks after TACE. Results No significant difference was found in the tumor volume between the 3 groups before TACE (P>0.05). The rabbits receiving TACE with iodized oil, especially at the high dose, showed significantly reduced tumor volume as compared with the control group (P<0.0l). TACE with high-dose-iodized oil resulted in significantly increased tumor necrosis rate in comparison with the control group and TACE with a routine dose of iodized oil (P<0.05); high-dose iodized oil TACE was also associated with reduced intrahepatic and lung metastasis as compared routine dose iodized oil TACE (P<0.05). Conclusion TACE with high-dose iodized oil can obviously inhibit the growth and intrahepatic and lung metastasis of transplanted VX2 liver tumor in rabbits.