CAJ | 학술논문

[目的]制备银杏酸和槟榔碱二元微乳剂.[方法]采用滴定法绘制伪三元相图,考察表面活性剂、助表面活性剂和油相对微乳区的影响.[结果]当DBS-Ca和农乳600~#的质量比Km=1∶ 1时,DBS-Ca-农乳600~#-乙酸乙酯-水体系形成的微乳区面积最大,对药物的容量也最大;当表面活性剂和助表面活性剂的总质量与乙酸乙酯的质量比(AS/O)=3∶ 2时,制得的二元微乳剂最稳定.[结论]该微乳体系制得的银杏酸和槟榔碱二元微乳剂符合要求.
[목적]제비은행산화빈랑감이원미유제.[방법]채용적정법회제위삼원상도,고찰표면활성제、조표면활성제화유상대미유구적영향.[결과]당DBS-Ca화농유600~#적질량비Km=1∶ 1시,DBS-Ca-농유600~#-을산을지-수체계형성적미유구면적최대,대약물적용량야최대;당표면활성제화조표면활성제적총질량여을산을지적질량비(AS/O)=3∶ 2시,제득적이원미유제최은정.[결론]해미유체계제득적은행산화빈랑감이원미유제부합요구.
[Objective] The aim was to prepare binary micro-emulsion of ginkgolic acids and arecoline.[Method] By using titration method to prepare the pseudoternary phase diagram,the effects of surfactants,co-surfactants,oils on micro-emulsion regions were examined.[Result] The results showed that the area of the micro-emulsion was the largest when the Km value was 1∶ 1 in the system of DBS-Ca/phenylethyl phenol polyoxyethylene ether/ethyl acetate/water,which had the maximum capacity of drugs.When the value of AS/O equaled 3∶ 2,the binary micro-emulsion had the best stability.[Conclusion] The binary micro-emulsion of ginkgolic acids and arecoline obtained by this system suffices the quality standard of micro-emulsion.