中国医药工业杂志
中國醫藥工業雜誌
중국의약공업잡지
CHINESE JOURNAL OF PHARMACEUTICALS
2010年
3期
211-212,231
,共3页
阿莫达非尼%手性固定相%对映异构体%高效液相色谱%测定
阿莫達非尼%手性固定相%對映異構體%高效液相色譜%測定
아막체비니%수성고정상%대영이구체%고효액상색보%측정
armodafinil%chiral stationary phase%enantiomer%HPLC%determination
建立了HPLC法拆分莫达非尼,并检测阿莫达非尼的(S)-型异构体.使用α-酸性糖蛋白(AGP)手性固定相,以0.05 mol/L乙酸铵水溶液(含3%异丙醇,pH 6.8)为流动相,检测波长225 nm,阿莫达非尼与其(S)-型异构体分离完全,前者的检测限为0.05μg/ml.
建立瞭HPLC法拆分莫達非尼,併檢測阿莫達非尼的(S)-型異構體.使用α-痠性糖蛋白(AGP)手性固定相,以0.05 mol/L乙痠銨水溶液(含3%異丙醇,pH 6.8)為流動相,檢測波長225 nm,阿莫達非尼與其(S)-型異構體分離完全,前者的檢測限為0.05μg/ml.
건립료HPLC법탁분막체비니,병검측아막체비니적(S)-형이구체.사용α-산성당단백(AGP)수성고정상,이0.05 mol/L을산안수용액(함3%이병순,pH 6.8)위류동상,검측파장225 nm,아막체비니여기(S)-형이구체분리완전,전자적검측한위0.05μg/ml.
A chiral HPLC method was established for the separation of modafinil and determination of the (S) - enantiomer in armodafinil. An α-AGP column was used with the mobile phase of 0.05 mol/L ammonium acetate solution (containing 3 % 2-propanol, pH 6.8) at the detection wavelength of 225 nm. Armodafinil and its (S) -enantiomer were separated completely and its limit of detection was 0.05 μg/ml.
