CAJ | 학술논문

目的探讨基础乙型肝炎疫苗免疫效果及其影响因素.方法选择宁波市区完成基础乙型肝炎免疫的466名入园儿童进行研究,采用时间分辨免疫荧光分析方法进行抗-HBs水平检测；应用单因素x2分析和多因素Logistic回归分析进行免疫效果影响因素分析.结果 466名接受基础免疫的儿童中,371人(79.61％)抗-HBs阳性,95人(20.39％)抗-HBs阴性.多元回归分析显示,抗-HBs阴性的主要影响因素有:接种单位属地(OR=0.581,95％ CI:0.336～ 1.005)、家庭经济水平(OR=2.047,95％CI:1.349 ～3.106).结论接种属地和家庭经济状况可能是影响乙型肝炎疫苗免疫效果的因素.
목적 탐토기출을형간염역묘면역효과급기영향인소.방법 선택저파시구완성기출을형간염면역적466명입완인동진행연구,채용시간분변면역형광분석방법진행항-HBs수평검측；응용단인소x2분석화다인소Logistic회귀분석진행면역효과영향인소분석.결과 466명접수기출면역적인동중,371인(79.61％)항-HBs양성,95인(20.39％)항-HBs음성.다원회귀분석현시,항-HBs음성적주요영향인소유:접충단위속지(OR=0.581,95％ CI:0.336～ 1.005)、가정경제수평(OR=2.047,95％CI:1.349 ～3.106).결론 접충속지화가정경제상황가능시영향을형간염역묘면역효과적인소.
Objective To analyze the impact factors of immune effect after basic hepatitis B vaccination.Methods Four hundred and sixty-six kindergarten children who had finished basic hepatitis B vaccination in Ningbo city were enrolled in the study,and their anti-HBs levels were detected by time-resolved fhourescence immunoassay.The data were analyzed by single chi-square analysis and multiple factor regression analysis.Results All of the 466 children were given basic hepatitis B vaccination,79.61％ (371 cases) of them showed immune response,and the non-response rate was 20.39％(95 cases).Multiple factor regression analysis indicated that the main effective factors of children who had no response to the basic hepatitis B vaccination were the vaccination area( OR =0.581,95％ CI:0.336-1.005)and the home economics level ( OR =2.047,95 ％ CI:1.349-3.106).Conclusions The vaccination area and the home economics level could be the impact factors of immune effect after basic hepatitis B vaccination.