中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2012年
5期
491-493,502
,共4页
常淑婷%付陈超%高喜容%刘新晖
常淑婷%付陳超%高喜容%劉新暉
상숙정%부진초%고희용%류신휘
早产儿视网膜病变%出生体重%胎龄
早產兒視網膜病變%齣生體重%胎齡
조산인시망막병변%출생체중%태령
Retinopathy of prematurity%Birth weight%Geststional age
目的 探讨早产儿视网膜病变(retinopathy of prematurity,ROP)发病情况及相关危险因素.方法 回顾性分析2008年12月至2011年2月我院出生的1 356例体重2500 g以下或胎龄小于37周早产儿的临床资料,分为ROP组(n=208)和非ROP组(n=1148),分析全部早产儿自生后4～6周或矫正胎龄32周筛查眼底改变情况.结果 1356例早产儿中,208例发生ROP,发病率为15.34％,其中,严重病变36例(2.65％).与非ROP组相比,ROP组患儿在出生体重[(1 528 ±243)g vs(1 960±187)g]、胎龄[(30.92±0.72)周vs (32.87±1.28)周]、吸氧＞8d(123例vs 865例)、应用肺表面活性物质(18例vs 216例)、败血症(42例vs 154例)、宫内窘迫(63例vs 511例)、贫血(64例vs 237例)等方面比较,差异有统计学意义(P均＜0.05).Logistic回归分析结果显示出生体重、胎龄、吸氧＞8d、败血症及应用肺表面活性物质是ROP发生的高危因素(P＜0.05).同时,不同出生体重、不同胎龄患儿ROP发病率比较,差异均有统计学意义(P＜0.05).结论 出生体重及胎龄越低,ROP发病率越高,病变程度越严重.婴儿出生的成熟度越低,ROP尤其是严重ROP发病可能性越高.
目的 探討早產兒視網膜病變(retinopathy of prematurity,ROP)髮病情況及相關危險因素.方法 迴顧性分析2008年12月至2011年2月我院齣生的1 356例體重2500 g以下或胎齡小于37週早產兒的臨床資料,分為ROP組(n=208)和非ROP組(n=1148),分析全部早產兒自生後4～6週或矯正胎齡32週篩查眼底改變情況.結果 1356例早產兒中,208例髮生ROP,髮病率為15.34％,其中,嚴重病變36例(2.65％).與非ROP組相比,ROP組患兒在齣生體重[(1 528 ±243)g vs(1 960±187)g]、胎齡[(30.92±0.72)週vs (32.87±1.28)週]、吸氧＞8d(123例vs 865例)、應用肺錶麵活性物質(18例vs 216例)、敗血癥(42例vs 154例)、宮內窘迫(63例vs 511例)、貧血(64例vs 237例)等方麵比較,差異有統計學意義(P均＜0.05).Logistic迴歸分析結果顯示齣生體重、胎齡、吸氧＞8d、敗血癥及應用肺錶麵活性物質是ROP髮生的高危因素(P＜0.05).同時,不同齣生體重、不同胎齡患兒ROP髮病率比較,差異均有統計學意義(P＜0.05).結論 齣生體重及胎齡越低,ROP髮病率越高,病變程度越嚴重.嬰兒齣生的成熟度越低,ROP尤其是嚴重ROP髮病可能性越高.
목적 탐토조산인시망막병변(retinopathy of prematurity,ROP)발병정황급상관위험인소.방법 회고성분석2008년12월지2011년2월아원출생적1 356례체중2500 g이하혹태령소우37주조산인적림상자료,분위ROP조(n=208)화비ROP조(n=1148),분석전부조산인자생후4～6주혹교정태령32주사사안저개변정황.결과 1356례조산인중,208례발생ROP,발병솔위15.34％,기중,엄중병변36례(2.65％).여비ROP조상비,ROP조환인재출생체중[(1 528 ±243)g vs(1 960±187)g]、태령[(30.92±0.72)주vs (32.87±1.28)주]、흡양＞8d(123례vs 865례)、응용폐표면활성물질(18례vs 216례)、패혈증(42례vs 154례)、궁내군박(63례vs 511례)、빈혈(64례vs 237례)등방면비교,차이유통계학의의(P균＜0.05).Logistic회귀분석결과현시출생체중、태령、흡양＞8d、패혈증급응용폐표면활성물질시ROP발생적고위인소(P＜0.05).동시,불동출생체중、불동태령환인ROP발병솔비교,차이균유통계학의의(P＜0.05).결론 출생체중급태령월저,ROP발병솔월고,병변정도월엄중.영인출생적성숙도월저,ROP우기시엄중ROP발병가능성월고.
Objective To investigate the present incidence and the risk factors of retinopathy of prematurity (ROP).Methods The clinical data of 1 356 premature infants who were born in our hospital from Dec 2008 to Feb 2011 with birth weight of 2 500 g or less and gestational age of 37 weeks or less were analyzed retrospectively,and divided into ROP group(n =208) and without ROP group(n =1 148).They were screened for ROP from 4 ～ 6 weeks of chronological age or 32 weeks of postmenstrual age.Results In 1 356 cases,there were 208 cases with ROP,the incident rate was 15.34％,of which 36 cases were severe diseases (2.65％).Compared with the infants without ROP,the development of ROP was correlated with birth weight [(1 528 ±243) g vs (1 960 ± 187) g],gestational age [(30.92 ±0.72) weeks vs (32.87 ± 1.28) weeks],oxygen uptake time ＞ 8 d (123 cases vs 865 cases),pulmonary surfactants (18 cases vs 216 cases),septicemia (42 cases vs 154 cases),in utero distress (63 cases vs 511 cases) and anemia (64 cases vs 237 cases) (P ＜ 0.05).Logistic regression analysis suggested that birth weight,gestational age,oxygen uptake time ＞8 d,septicemia and pulmonary surfactants were significant risk factors associated with the development of ROP(P ＜ 0.05).Meanwhile,there were significant differences in the incidence of infants with ROP at different birth weight and different gestational age (P ＜ 0.05).Conclusion The birth weight and gestational age are lower,the incidence of ROP is higher and the disease is more serious.The probability of ROP,particularly severe ROP,is highest in the most immature infants while it is lower in the least immature ones.
