CAJ | 학술논문

目的观察降钙素基因相关肽(CGRP)免疫阳性神经纤维在早期激素性股骨头缺血坏死(SANFH)骨组织中的变化,并探讨其意义.方法采用大剂量冲击造模方法,造成SD大鼠SANFH模型.应用免疫组织化学技术光镜下观察CGRP免疫阳性神经纤维在SANFH负重区骨组织中的变化规律.结果股骨头软骨下骨髓腔内CGRP免疫阳性神经纤维的数目先增多,后减少(第6周达高峰,为10.28±0.66),均较正常组增多,差异有统计学意义(P＜0.01).结论 (1)CGRP免疫阳性神经纤维在激素性股骨头缺血坏死组织中的分布发生变化;(2)CGRP免疫阳性神经纤维参与激素性股骨头缺血坏死后的修复过程.
목적 관찰강개소기인상관태(CGRP)면역양성신경섬유재조기격소성고골두결혈배사(SANFH)골조직중적변화,병탐토기의의.방법 채용대제량충격조모방법,조성SD대서SANFH모형.응용면역조직화학기술광경하관찰CGRP면역양성신경섬유재SANFH부중구골조직중적변화규률.결과 고골두연골하골수강내CGRP면역양성신경섬유적수목선증다,후감소(제6주체고봉,위10.28±0.66),균교정상조증다,차이유통계학의의(P＜0.01).결론 (1)CGRP면역양성신경섬유재격소성고골두결혈배사조직중적분포발생변화;(2)CGRP면역양성신경섬유삼여격소성고골두결혈배사후적수복과정.
Objective To observe the changes of calcitonin gene-related peptide(CGRP) -immunoreactive positive nerve fibers innervation in bone tissue of femoral heads during the pathological process of early steroid-induced avascular necrosis of the femoral head (SANFH), and explore its significance.Methpathological group of SANFH was induced.Immunohistochemical technique was used and the changes of CGRP-immunoreactive positive nerve fibers innervation in weight bearing area of the femoral heads during the pathological process of early SANFH were observed.Result The number of CGRP-immunoreactive nerves increased first and then decreased ( Peaked at 6 weeks, 10.28 ± 0.66 ), but it was more than that ofnormal control group.There was significant difference between two groups ( P ＜ 0.01 ).Conclusion There were changes in the distribution of CGRP-immunoreactive positive nerves fiber during the process of bone repair after SANFH.CGRP-immunoreactive positive nerves fiber might take part in the process of bone repair in SANFH.