CAJ | 학술논문

RON的激活与人体内某些上皮源性肿瘤的发生存在密切关系.在体内,RON基因主要表达于上皮细胞及食管、胃、小肠、肾脏、宫颈、皮肤、膀胱等组织和器官,在肺泡、甲状腺、心脏、平滑肌、成纤维细胞、内皮细胞中几乎没有表达.RON在其配体巨噬细胞刺激蛋白的刺激下,激活后具有调节上皮细胞扩散、转移、微管形成等功能.同时,RON本身也可以诱导细胞发生上皮一间质转化,引起细胞扩散和浸润.研究RON在肿瘤发生中的作用可以为其作为靶向药物干预治疗提供可靠的依据.
RON적격활여인체내모사상피원성종류적발생존재밀절관계.재체내,RON기인주요표체우상피세포급식관、위、소장、신장、궁경、피부、방광등조직화기관,재폐포、갑상선、심장、평활기、성섬유세포、내피세포중궤호몰유표체.RON재기배체거서세포자격단백적자격하,격활후구유조절상피세포확산、전이、미관형성등공능.동시,RON본신야가이유도세포발생상피일간질전화,인기세포확산화침윤.연구RON재종류발생중적작용가이위기작위파향약물간예치료제공가고적의거.
The activation of RON is associated with the development of epithelial tumours. RON isalmost exclusively expressed at variable levels in epithelial cells and esophagus, stomach, intestine, kidney, cervix, skin, bladder and others in vivo, but hardly detected in pulmonary alveoli, normal thyroid cells,heart, smooth muscle, fibroblast and endothelial cell. RON is activated by binding with macrophage stimulating protein, then it can regulate the functions of endothelial cell extension,movement and microtubule formation. Meanwhile,RON also can induce epithelial-mesenchymal transition to cause cell diffusion and infiltration. Understanding the roles of RON in cancer development should provide a basis for validating RON as a drug target for therapeutic intervention.