国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
INTERNATIONAL JOURNAL OF UROLOGY AND NEPHROLOGY
2009年
3期
306-309
,共4页
肾疾病%肾小球%免疫球蛋白类%补体
腎疾病%腎小毬%免疫毬蛋白類%補體
신질병%신소구%면역구단백류%보체
Kidney Diseases%Kidney Glomemlus%lmmunoglobulins
目的 探讨肾小球疾病免疫球蛋白、补体水平与免疫病理的相关性.方法 112 例肾小球疾病患者,14 例健康人测定血清免疫球蛋白及补体,112 例肾小球疾病患者,112 例患者行肾活组织病理检查.结果 112 例肾小球疾病患者 IgG 升高 11 例(9.82%),降低 29 例(25.89%),IgA 升高 33 例(29.46%),降低 2 例(1.79%).IgM 升高 7 例(6.25%),降低 3 例(2.68%),三种免疫球蛋白的变化有显著差异(x2=70.587,P=O.000);C3 减低 29 例(25.89%),C4减低 32 例(28.57%),两者比较无显著差异(X2=0.203,P=0.653).免疫荧光阳性率依次为C3(50%)>lgA(49.11%)>IgG(40.18%)>lgM(21.43%)>C4(14.29%)(x2=49.303,P=0.000);免疫荧光 IgA 阳性者血清 lgA 水平较阴性者高(P=0.042),C3、CA阳性者血清 C3、c4 水平较阴性者低(P=0,P=0.007),IgG、IgM 阳性者血清 IgG、lgM 水平与阴性者比较无差异(P=0.136,P=0.383).结论 肾小球疾病存在体液免疫紊乱,测定血清免疫球蛋白、补体及行肾组织免疫病检有助于了解体液免疫状况,估计疾病活动度,判断疗效,但两种检查之间无明显的相关性,可相互补充,不能相互替代.
目的 探討腎小毬疾病免疫毬蛋白、補體水平與免疫病理的相關性.方法 112 例腎小毬疾病患者,14 例健康人測定血清免疫毬蛋白及補體,112 例腎小毬疾病患者,112 例患者行腎活組織病理檢查.結果 112 例腎小毬疾病患者 IgG 升高 11 例(9.82%),降低 29 例(25.89%),IgA 升高 33 例(29.46%),降低 2 例(1.79%).IgM 升高 7 例(6.25%),降低 3 例(2.68%),三種免疫毬蛋白的變化有顯著差異(x2=70.587,P=O.000);C3 減低 29 例(25.89%),C4減低 32 例(28.57%),兩者比較無顯著差異(X2=0.203,P=0.653).免疫熒光暘性率依次為C3(50%)>lgA(49.11%)>IgG(40.18%)>lgM(21.43%)>C4(14.29%)(x2=49.303,P=0.000);免疫熒光 IgA 暘性者血清 lgA 水平較陰性者高(P=0.042),C3、CA暘性者血清 C3、c4 水平較陰性者低(P=0,P=0.007),IgG、IgM 暘性者血清 IgG、lgM 水平與陰性者比較無差異(P=0.136,P=0.383).結論 腎小毬疾病存在體液免疫紊亂,測定血清免疫毬蛋白、補體及行腎組織免疫病檢有助于瞭解體液免疫狀況,估計疾病活動度,判斷療效,但兩種檢查之間無明顯的相關性,可相互補充,不能相互替代.
목적 탐토신소구질병면역구단백、보체수평여면역병리적상관성.방법 112 례신소구질병환자,14 례건강인측정혈청면역구단백급보체,112 례신소구질병환자,112 례환자행신활조직병리검사.결과 112 례신소구질병환자 IgG 승고 11 례(9.82%),강저 29 례(25.89%),IgA 승고 33 례(29.46%),강저 2 례(1.79%).IgM 승고 7 례(6.25%),강저 3 례(2.68%),삼충면역구단백적변화유현저차이(x2=70.587,P=O.000);C3 감저 29 례(25.89%),C4감저 32 례(28.57%),량자비교무현저차이(X2=0.203,P=0.653).면역형광양성솔의차위C3(50%)>lgA(49.11%)>IgG(40.18%)>lgM(21.43%)>C4(14.29%)(x2=49.303,P=0.000);면역형광 IgA 양성자혈청 lgA 수평교음성자고(P=0.042),C3、CA양성자혈청 C3、c4 수평교음성자저(P=0,P=0.007),IgG、IgM 양성자혈청 IgG、lgM 수평여음성자비교무차이(P=0.136,P=0.383).결론 신소구질병존재체액면역문란,측정혈청면역구단백、보체급행신조직면역병검유조우료해체액면역상황,고계질병활동도,판단료효,단량충검사지간무명현적상관성,가상호보충,불능상호체대.
Objectives To explore correlation between the levels of serum immunoglobulin,complement and immunopathology in glomerular disease.Methods 112 pafientw were taken renal biopsy end were detected level of serum immunoglobulin lgG.IgA,lgM and complement C3,C4.Results Though many of 112 patients'immunoglobulin increased or dereased,and C3,C4 dereased.The sequence ofimmunofluoreecence positive rate is C3 (50%)>IgA(49.11%)>IgG(40.18%)>IgM(21.43%)>C4(14.29%)(x2=49.303,P=0.000).The se - rum IgA level of IgA positive patients Was higher than the nagative patients(P=0.042).The serum C3,C4 level of C3,C4 positive patients are lower than thenagative patients(P=0,P=0.007).there is no significant difference in the serum.IgM,IgG of IgM,IgG positive patients and the nagative patients(P>0.05).Conclusions There is the disorder of humour immunity in glomerular disease.Detecting serum immunoglobulin and complement end exami - ning renal immunopathology can help to realize the status of humour immunity,estimate the active degree of the dis - ease,judge the effect of treat,but there is no relation between both.The both canmakeup each other,but they Can not substitution one another.
