中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2012年
28期
1954-1958
,共5页
叶双梅%韩敏%阚淳一%杨丽兰%杨洁%马全富%王世宣
葉雙梅%韓敏%闞淳一%楊麗蘭%楊潔%馬全富%王世宣
협쌍매%한민%감순일%양려란%양길%마전부%왕세선
食管肿瘤%胃肿瘤%直肠肿瘤%肿瘤转移
食管腫瘤%胃腫瘤%直腸腫瘤%腫瘤轉移
식관종류%위종류%직장종류%종류전이
Esophageal neoplasms%Stomach neoplasms%Rectal neoplasms%Neoplasmsmetastasis
目的 探讨信号素分子4C(Sema4C)在食管癌、胃癌以及直肠癌组织中的表达及其与肿瘤恶性程度的关系.方法 选择武汉同济医院病理科2008年1月至2010年12月存档的石蜡组织标本235份,其中食管癌50例,胃癌75例,直肠癌50例,以及癌旁正常黏膜各20例.应用免疫组织化学SP法检测Sema4C在各标本中的表达,并结合临床资料进行统计分析,评价Sema4C的表达情况与食管癌,胃癌及直肠癌临床病理特征的关系.结果 Sema4C在食管癌、胃癌及直肠癌组织中的阳性表达率均显著高于相应癌旁正常黏膜组织[80.0％(40例)比20.0％(4例),77.3％(58例)比25.0％(5例),80.0％(40例)比15.0％(3例),均P=0.000]；Sema4C在有淋巴结转移的癌组织中的表达阳性率均显著高于无淋巴结转移癌组织[90.3％(28例)比63.2％(12例)、85.0％(51例)比46.7％(7例)、92.0％(23例)比68.0％(17例),P=0.049、0.005、0.034].但Sema4C的表达与患者性别、年龄、肿瘤发生部位、癌细胞类型、肿瘤细胞分化程度、肿瘤大小、浸润深度及临床分期均无关(均P ＞0.05).结论 Sema4C在食管癌,胃癌以及直肠癌组织中高表达,并与淋巴结转移密切相关,可能在3种恶性肿瘤的侵袭转移过程中发挥重要作用.
目的 探討信號素分子4C(Sema4C)在食管癌、胃癌以及直腸癌組織中的錶達及其與腫瘤噁性程度的關繫.方法 選擇武漢同濟醫院病理科2008年1月至2010年12月存檔的石蠟組織標本235份,其中食管癌50例,胃癌75例,直腸癌50例,以及癌徬正常黏膜各20例.應用免疫組織化學SP法檢測Sema4C在各標本中的錶達,併結閤臨床資料進行統計分析,評價Sema4C的錶達情況與食管癌,胃癌及直腸癌臨床病理特徵的關繫.結果 Sema4C在食管癌、胃癌及直腸癌組織中的暘性錶達率均顯著高于相應癌徬正常黏膜組織[80.0％(40例)比20.0％(4例),77.3％(58例)比25.0％(5例),80.0％(40例)比15.0％(3例),均P=0.000]；Sema4C在有淋巴結轉移的癌組織中的錶達暘性率均顯著高于無淋巴結轉移癌組織[90.3％(28例)比63.2％(12例)、85.0％(51例)比46.7％(7例)、92.0％(23例)比68.0％(17例),P=0.049、0.005、0.034].但Sema4C的錶達與患者性彆、年齡、腫瘤髮生部位、癌細胞類型、腫瘤細胞分化程度、腫瘤大小、浸潤深度及臨床分期均無關(均P ＞0.05).結論 Sema4C在食管癌,胃癌以及直腸癌組織中高錶達,併與淋巴結轉移密切相關,可能在3種噁性腫瘤的侵襲轉移過程中髮揮重要作用.
목적 탐토신호소분자4C(Sema4C)재식관암、위암이급직장암조직중적표체급기여종류악성정도적관계.방법 선택무한동제의원병이과2008년1월지2010년12월존당적석사조직표본235빈,기중식관암50례,위암75례,직장암50례,이급암방정상점막각20례.응용면역조직화학SP법검측Sema4C재각표본중적표체,병결합림상자료진행통계분석,평개Sema4C적표체정황여식관암,위암급직장암림상병리특정적관계.결과 Sema4C재식관암、위암급직장암조직중적양성표체솔균현저고우상응암방정상점막조직[80.0％(40례)비20.0％(4례),77.3％(58례)비25.0％(5례),80.0％(40례)비15.0％(3례),균P=0.000]；Sema4C재유림파결전이적암조직중적표체양성솔균현저고우무림파결전이암조직[90.3％(28례)비63.2％(12례)、85.0％(51례)비46.7％(7례)、92.0％(23례)비68.0％(17례),P=0.049、0.005、0.034].단Sema4C적표체여환자성별、년령、종류발생부위、암세포류형、종류세포분화정도、종류대소、침윤심도급림상분기균무관(균P ＞0.05).결론 Sema4C재식관암,위암이급직장암조직중고표체,병여림파결전이밀절상관,가능재3충악성종류적침습전이과정중발휘중요작용.
Objective To explore the expression and clinical significance of signal protein Sema4C in esophageal cancer,gastric cancer and rectal cancer.Methods Fifty esophageal cancer,75 gastric cancer,50 rectal cancer and 20 corresponding normal mucous membrane specimens,collected during the period of January 2008 to December 2010,were detected with streptavidin-perosidase immunohistochemistry to detect the expression levels of Sema4C And the relationships of the Sema4C expression with clinicopathological data was analyzed.Results The expression levels of Sema4C in three kinds of cancers were significantly higher than the corresponding normal mucous membranes ( 80.0％ ( n =40 ) vs 20.0％ (n=4),77.3％ (n=58) vs25.0％ (n=5),80.0％ (n=40) vs15.0％ (n=3),allP=0.000).Furthermore,the percentage of Sema4C positive cells was significantly higher in carcinoma nests of tumors with lymphatic metastasis than those without (90.3％ ( n =28 ) vs 63.2％ ( n =12),85.0％ ( n =51 ) vs 46.7％ (n=7),92.0％ (n =23) vs 68.0％ (n=17),P=0.049,0.005,0.034).However,no significant correlations were found between the Sema4C expression with gender,age,location of tumors,types of cancer cells,cell differentiation,tumor size,depth of invasion or tumor stage (all P ＞ 0.05 ).Conclusion There is a high expression of Sema4C in esophageal cancer,gastric cancer and rectal cancer.And it is strongly correlated with lymphatic metastasis.Thus Sema4C may play critical roles in the invasion and lymphatic metastasis of esophageal cancer,gastric cancer and rectal cancer.
