肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
8期
544-546
,共3页
杨学财%尚伟%钟凤%贾暮云%卜令学%李宁毅
楊學財%尚偉%鐘鳳%賈暮雲%蔔令學%李寧毅
양학재%상위%종봉%가모운%복령학%리저의
舌肿瘤%尿纤溶酶原激活物%多态性,单核苷酸
舌腫瘤%尿纖溶酶原激活物%多態性,單覈苷痠
설종류%뇨섬용매원격활물%다태성,단핵감산
Tongue neoplasms%Urinary plasminogen activator%Polymorphism,single nucleotide
目的 研究尿激酶型纤溶酶原激活剂( PLAU)基因单核苷酸多态性与舌癌发病的相关性.方法 收集97例舌癌患者为病例组,以91名健康人作为对照组.采用聚合酶链反应-限制性片段长度多态性( PCR-RFLP)方法对所有受试者进行PLAU基因多态位点分型,采用病例对照相关性研究方法,研究其与舌癌发病的关系.用SPSS11.5统计软件进行等位基因和基因型分布的比较及其与疾病的关联分析.结果 受试者的PLAU基因rs2227564位点存在C/T多态性,Logistic回归分析显示,与CT 型及TT型相比,CC基因型是导致舌癌的危险因素(校正后OR=1.281,95％CI 1.098～ 2.577,P=0.037).结论 PLAU基因变异与舌癌的发生相关.
目的 研究尿激酶型纖溶酶原激活劑( PLAU)基因單覈苷痠多態性與舌癌髮病的相關性.方法 收集97例舌癌患者為病例組,以91名健康人作為對照組.採用聚閤酶鏈反應-限製性片段長度多態性( PCR-RFLP)方法對所有受試者進行PLAU基因多態位點分型,採用病例對照相關性研究方法,研究其與舌癌髮病的關繫.用SPSS11.5統計軟件進行等位基因和基因型分佈的比較及其與疾病的關聯分析.結果 受試者的PLAU基因rs2227564位點存在C/T多態性,Logistic迴歸分析顯示,與CT 型及TT型相比,CC基因型是導緻舌癌的危險因素(校正後OR=1.281,95％CI 1.098～ 2.577,P=0.037).結論 PLAU基因變異與舌癌的髮生相關.
목적 연구뇨격매형섬용매원격활제( PLAU)기인단핵감산다태성여설암발병적상관성.방법 수집97례설암환자위병례조,이91명건강인작위대조조.채용취합매련반응-한제성편단장도다태성( PCR-RFLP)방법대소유수시자진행PLAU기인다태위점분형,채용병례대조상관성연구방법,연구기여설암발병적관계.용SPSS11.5통계연건진행등위기인화기인형분포적비교급기여질병적관련분석.결과 수시자적PLAU기인rs2227564위점존재C/T다태성,Logistic회귀분석현시,여CT 형급TT형상비,CC기인형시도치설암적위험인소(교정후OR=1.281,95％CI 1.098～ 2.577,P=0.037).결론 PLAU기인변이여설암적발생상관.
Objective To determine association between tongue carcinoma and polymorphism of urokinase-type plasminogen activator (PLAU) gene.Methods PLAU genotypes of 97 patients with tongue carcinoma and 91 health controls were examined by the PCR-RFLP method.Statistical analyses included a chi-square test for homogeneity and logistic regression analysis.Results The polymorphism in PLAU gene was rs2227564 C/T.Logistic analyses indicated that compared with CT and TT genotypes,CC genotype was risk factor for development of tongue carcinoma (adjusted OR =1.281,95 ％ CI 1.098-2.577,P =0.037).Conclusion PLAU polymorphism may be associated with development of tongue carcinoma.
