中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2012年
1期
57-61
,共5页
战义强%余金明%胡大一%毛勇%丁荣晶%孙艺红%张李军%傅媛媛%李社昌%张芬
戰義彊%餘金明%鬍大一%毛勇%丁榮晶%孫藝紅%張李軍%傅媛媛%李社昌%張芬
전의강%여금명%호대일%모용%정영정%손예홍%장리군%부원원%리사창%장분
空腹血糖%高血压%心脑血管疾病%交互分析
空腹血糖%高血壓%心腦血管疾病%交互分析
공복혈당%고혈압%심뇌혈관질병%교호분석
Fasting glucose%Hypertension%Cardiovascular disease%Transactional analysis
目的 探讨空腹血糖和高血压与心脑血管疾病的关系及二者对心脑血管疾病的交互作用强度.方法于2007年5-8月,采用横断面研究的方法,调查北京社区常住居民10 054名,运用非条件logistic回归模型分析空腹血糖升高和高血压与心血管疾病以及脑卒中的关系,通过模型中纳入空腹血糖和高血压的乘积项分析其相乘交瓦作用,通过Bootstrap法计算相对超额危险度比(RERI),归因比(AP)和交互作用指数(S)及其可信区间来评价空腹血糖受损和高血压以及糖尿病和高血压之间的相加交瓦作用.结果调整年龄、性别、吸烟、饮酒、体质指数(BMI)和地区后,空腹血糖和高血压的乘积项无统计学意义,二者对心血管疾病和脑卒中均无相乘交互作用；糖尿病和高血压对心血管疾病的相加交互作用指标RERI、AP和S及其95％可信区间分别为0.64(0.03～1.25)、0.27(0.01～0.47)和1.83(1.02～5.13),说明二者之间存在相加交瓦作用,但对脑卒中无相加交互作用；空腹血糖受损和高血压对心血管疾病和脑卒中均无相加交互作用.结论高血压是心血管疾病和脑卒中的危险因素,糖尿病是脑卒中的危险因素.糖尿病和高血压对心血管疾病存在相加交互作用,同时患有糖尿病和高血压会使心血管疾病的患病风险增加.
目的 探討空腹血糖和高血壓與心腦血管疾病的關繫及二者對心腦血管疾病的交互作用彊度.方法于2007年5-8月,採用橫斷麵研究的方法,調查北京社區常住居民10 054名,運用非條件logistic迴歸模型分析空腹血糖升高和高血壓與心血管疾病以及腦卒中的關繫,通過模型中納入空腹血糖和高血壓的乘積項分析其相乘交瓦作用,通過Bootstrap法計算相對超額危險度比(RERI),歸因比(AP)和交互作用指數(S)及其可信區間來評價空腹血糖受損和高血壓以及糖尿病和高血壓之間的相加交瓦作用.結果調整年齡、性彆、吸煙、飲酒、體質指數(BMI)和地區後,空腹血糖和高血壓的乘積項無統計學意義,二者對心血管疾病和腦卒中均無相乘交互作用；糖尿病和高血壓對心血管疾病的相加交互作用指標RERI、AP和S及其95％可信區間分彆為0.64(0.03～1.25)、0.27(0.01～0.47)和1.83(1.02～5.13),說明二者之間存在相加交瓦作用,但對腦卒中無相加交互作用；空腹血糖受損和高血壓對心血管疾病和腦卒中均無相加交互作用.結論高血壓是心血管疾病和腦卒中的危險因素,糖尿病是腦卒中的危險因素.糖尿病和高血壓對心血管疾病存在相加交互作用,同時患有糖尿病和高血壓會使心血管疾病的患病風險增加.
목적 탐토공복혈당화고혈압여심뇌혈관질병적관계급이자대심뇌혈관질병적교호작용강도.방법우2007년5-8월,채용횡단면연구적방법,조사북경사구상주거민10 054명,운용비조건logistic회귀모형분석공복혈당승고화고혈압여심혈관질병이급뇌졸중적관계,통과모형중납입공복혈당화고혈압적승적항분석기상승교와작용,통과Bootstrap법계산상대초액위험도비(RERI),귀인비(AP)화교호작용지수(S)급기가신구간래평개공복혈당수손화고혈압이급당뇨병화고혈압지간적상가교와작용.결과조정년령、성별、흡연、음주、체질지수(BMI)화지구후,공복혈당화고혈압적승적항무통계학의의,이자대심혈관질병화뇌졸중균무상승교호작용；당뇨병화고혈압대심혈관질병적상가교호작용지표RERI、AP화S급기95％가신구간분별위0.64(0.03～1.25)、0.27(0.01～0.47)화1.83(1.02～5.13),설명이자지간존재상가교와작용,단대뇌졸중무상가교호작용；공복혈당수손화고혈압대심혈관질병화뇌졸중균무상가교호작용.결론고혈압시심혈관질병화뇌졸중적위험인소,당뇨병시뇌졸중적위험인소.당뇨병화고혈압대심혈관질병존재상가교호작용,동시환유당뇨병화고혈압회사심혈관질병적환병풍험증가.
Objective To explore the relationship and interaction of elevated fasting glucose and hypertension on cardiocerebral vascular disease.Methods 10 054 males and females were recruited for our cross-sectional study during May 2007 to August 2007.Unconditional logistic regression was used to analysis the relationship between fasting glucose and hypertension on cardiocerebral vascular disease.A product of fasting glucose and hypertension was added to the logistic regression model to evaluate the multiplicative interaction and relative excess risk of interaction(RERI),attributable proportion(AP)of interaction and synergy index(S)was applied to evaluate the additive interaction of the two factors.Bootstrap was used to calculate 95％ confidence intervals(CI)of RERI,AP and S.Results After adjusting age,gender,smoking,drinking,body mass index(BMI)and region,the product of fasting glucose and hypertension was not statistically significant,which means there was no multiplicative interaction between the two.But the additive indexes RERI,AP and S with 95％ CI of diabetes and hypertension were 0.64(0.03,1.25),0.27(0.01,O.47)and 1.83(1.02,5.13)respectively,which means significant additive interaction was shown between the two on cardiovascular disease but not no stroke.And there were no additive interaction bmtween impaired fasting glucose on cardiovascular disease or stroke.Conclusions Hypertension was independently related to cardiovascular disease and stroke in Beijing citizens,and diabetes were independently related to stroke.There was additive interaction between diabetes and hypertension on cardiovascular disease.
